Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor
Abstract Background 2‐deoxy‐2‐[fluorine‐18] fluoro‐d‐glucose (18F‐FDG) positron emission tomography (18F‐FDG‐PET) is a convenient modality to assess the metabolic activity within tumor cells. However, there is no consensus regarding the relationship between 18F‐FDG uptake and the immune environment...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.4176 |
| _version_ | 1818724831874514944 |
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| author | Hisao Imai Kyoichi Kaira Kosuke Hashimoto Hiroyuki Nitanda Ryo Taguchi Akitoshi Yanagihara Tetsuya Umesaki Ou Yamaguchi Atsuto Mouri Tomonori Kawasaki Masanori Yasuda Kunihiko Kobayashi Hirozo Sakaguchi Ichiei Kuji Hiroshi Kagamu |
| author_facet | Hisao Imai Kyoichi Kaira Kosuke Hashimoto Hiroyuki Nitanda Ryo Taguchi Akitoshi Yanagihara Tetsuya Umesaki Ou Yamaguchi Atsuto Mouri Tomonori Kawasaki Masanori Yasuda Kunihiko Kobayashi Hirozo Sakaguchi Ichiei Kuji Hiroshi Kagamu |
| author_sort | Hisao Imai |
| collection | DOAJ |
| description | Abstract Background 2‐deoxy‐2‐[fluorine‐18] fluoro‐d‐glucose (18F‐FDG) positron emission tomography (18F‐FDG‐PET) is a convenient modality to assess the metabolic activity within tumor cells. However, there is no consensus regarding the relationship between 18F‐FDG uptake and the immune environment in thymic epithelial tumors (TETs). We conducted a clinicopathological study to elucidate the relationship between 18F‐FDG uptake and programmed death ligands 1 and 2 (PD‐L1/PD‐L2) expression in patients with TETs. Methods: A total of 108 patients with histologically confirmed TETs classified as thymomas or thymic carcinomas who underwent surgical resection or biopsy or needle biopsy and 18F‐FDG PET before any treatment between August 2007 and March 2020 were enrolled in this study. Tumor specimens underwent immunohistochemical staining for PD‐L1, PD‐L2, GLUT1, HIF‐1α, VEGFR2, VEGF‐C, and β2 adrenergic receptor. Results: High uptakes of SUVmax, SUVmean, MTV, and TLG were identified in 28 (25.9%), 61 (56.5%), 55 (50.9%), and 55 (50.9%) of 108 patients, respectively. High uptake of SUVmax significantly correlated with PS (performance status) of 1–2, thymic carcinoma, and advanced stage, and SUVmax on 18F‐FDG uptake displayed a close association with PD‐L1 and PD‐L2 expressions, but not with MTV and TLG. Our analysis revealed that SUVmax was identified as being significant relationship for positive PD‐L1/PD‐L2 expression. GLUT1, HIF‐1α, and VEGFR2 were significantly associated with the expression of PD‐L1/PD‐L2 from the biological viewpoint. Conclusion 18F‐FDG accumulation was closely associated with the expression of PD‐L1/PD‐L2, which, in turn, was correlated with glucose metabolism and hypoxia. PD‐L1/PD‐L2 could affect the glucose metabolism and hypoxia in thymic tumor cells. |
| first_indexed | 2024-12-17T21:32:40Z |
| format | Article |
| id | doaj.art-a8142366e6a1438799401c111ae0c803 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-17T21:32:40Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-a8142366e6a1438799401c111ae0c8032022-12-21T21:31:50ZengWileyCancer Medicine2045-76342021-09-0110186317632610.1002/cam4.4176Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumorHisao Imai0Kyoichi Kaira1Kosuke Hashimoto2Hiroyuki Nitanda3Ryo Taguchi4Akitoshi Yanagihara5Tetsuya Umesaki6Ou Yamaguchi7Atsuto Mouri8Tomonori Kawasaki9Masanori Yasuda10Kunihiko Kobayashi11Hirozo Sakaguchi12Ichiei Kuji13Hiroshi Kagamu14Department of Respiratory Medicine Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Respiratory Medicine Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Respiratory Medicine Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of General Thoracic Surgery Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of General Thoracic Surgery Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of General Thoracic Surgery Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of General Thoracic Surgery Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Respiratory Medicine Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Respiratory Medicine Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Pathology Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Pathology Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Respiratory Medicine Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of General Thoracic Surgery Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Nuclear Medicine Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanDepartment of Respiratory Medicine Comprehensive Cancer Center International Medical CenterSaitama University Hospital Hidaka‐City Saitama JapanAbstract Background 2‐deoxy‐2‐[fluorine‐18] fluoro‐d‐glucose (18F‐FDG) positron emission tomography (18F‐FDG‐PET) is a convenient modality to assess the metabolic activity within tumor cells. However, there is no consensus regarding the relationship between 18F‐FDG uptake and the immune environment in thymic epithelial tumors (TETs). We conducted a clinicopathological study to elucidate the relationship between 18F‐FDG uptake and programmed death ligands 1 and 2 (PD‐L1/PD‐L2) expression in patients with TETs. Methods: A total of 108 patients with histologically confirmed TETs classified as thymomas or thymic carcinomas who underwent surgical resection or biopsy or needle biopsy and 18F‐FDG PET before any treatment between August 2007 and March 2020 were enrolled in this study. Tumor specimens underwent immunohistochemical staining for PD‐L1, PD‐L2, GLUT1, HIF‐1α, VEGFR2, VEGF‐C, and β2 adrenergic receptor. Results: High uptakes of SUVmax, SUVmean, MTV, and TLG were identified in 28 (25.9%), 61 (56.5%), 55 (50.9%), and 55 (50.9%) of 108 patients, respectively. High uptake of SUVmax significantly correlated with PS (performance status) of 1–2, thymic carcinoma, and advanced stage, and SUVmax on 18F‐FDG uptake displayed a close association with PD‐L1 and PD‐L2 expressions, but not with MTV and TLG. Our analysis revealed that SUVmax was identified as being significant relationship for positive PD‐L1/PD‐L2 expression. GLUT1, HIF‐1α, and VEGFR2 were significantly associated with the expression of PD‐L1/PD‐L2 from the biological viewpoint. Conclusion 18F‐FDG accumulation was closely associated with the expression of PD‐L1/PD‐L2, which, in turn, was correlated with glucose metabolism and hypoxia. PD‐L1/PD‐L2 could affect the glucose metabolism and hypoxia in thymic tumor cells.https://doi.org/10.1002/cam4.417618F‐FDG uptakeGLUT1HIF‐1αimmunohistochemistryPD‐L1PD‐L2 |
| spellingShingle | Hisao Imai Kyoichi Kaira Kosuke Hashimoto Hiroyuki Nitanda Ryo Taguchi Akitoshi Yanagihara Tetsuya Umesaki Ou Yamaguchi Atsuto Mouri Tomonori Kawasaki Masanori Yasuda Kunihiko Kobayashi Hirozo Sakaguchi Ichiei Kuji Hiroshi Kagamu Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor Cancer Medicine 18F‐FDG uptake GLUT1 HIF‐1α immunohistochemistry PD‐L1 PD‐L2 |
| title | Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor |
| title_full | Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor |
| title_fullStr | Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor |
| title_full_unstemmed | Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor |
| title_short | Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor |
| title_sort | tumor immunity is related to 18f fdg uptake in thymic epithelial tumor |
| topic | 18F‐FDG uptake GLUT1 HIF‐1α immunohistochemistry PD‐L1 PD‐L2 |
| url | https://doi.org/10.1002/cam4.4176 |
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