Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails
Psoriasis is a chronic inflammatory disease associated with immune system dysfunction that can affect nails, with a negative impact on patient life quality. Usually, nail psoriasis is associated with skin psoriasis and is therefore relatively simple to diagnose. However, up to 10% of nail psoriasis...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/2/280 |
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| author | Anca E. Chiriac Doina Azoicai Adina Coroaba Florica Doroftei Daniel Timpu Anca Chiriac Mihaela Pertea Elena-Laura Ursu Mariana Pinteala |
| author_facet | Anca E. Chiriac Doina Azoicai Adina Coroaba Florica Doroftei Daniel Timpu Anca Chiriac Mihaela Pertea Elena-Laura Ursu Mariana Pinteala |
| author_sort | Anca E. Chiriac |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory disease associated with immune system dysfunction that can affect nails, with a negative impact on patient life quality. Usually, nail psoriasis is associated with skin psoriasis and is therefore relatively simple to diagnose. However, up to 10% of nail psoriasis occurs isolated and may be difficult to diagnose by means of current methods (nail biopsy, dermoscopy, video dermoscopy, capillaroscopy, ultrasound of the nails, etc.). Since the nail is a complex biological tissue, mainly composes of hard α-keratins, the structural and morphological techniques can be used to analyze the human fingernails. The aim of this study was to corroborate the information obtained using Raman spectroscopy with those obtained by scanning electron microscopy (SEM) and X-ray diffractometry and to assess the potential of these techniques as non-invasive dermatologic diagnostic tools and an alternative to current methods. |
| first_indexed | 2024-03-09T05:37:56Z |
| format | Article |
| id | doaj.art-a81431fc4b65481fa03e72bbd9d8e309 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T05:37:56Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a81431fc4b65481fa03e72bbd9d8e3092023-12-03T12:27:15ZengMDPI AGMolecules1420-30492021-01-0126228010.3390/molecules26020280Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic NailsAnca E. Chiriac0Doina Azoicai1Adina Coroaba2Florica Doroftei3Daniel Timpu4Anca Chiriac5Mihaela Pertea6Elena-Laura Ursu7Mariana Pinteala8Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaCentre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaCentre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaPhotochemistry and Polyaddition Department, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaCentre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, RomaniaCentre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaCentre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaPsoriasis is a chronic inflammatory disease associated with immune system dysfunction that can affect nails, with a negative impact on patient life quality. Usually, nail psoriasis is associated with skin psoriasis and is therefore relatively simple to diagnose. However, up to 10% of nail psoriasis occurs isolated and may be difficult to diagnose by means of current methods (nail biopsy, dermoscopy, video dermoscopy, capillaroscopy, ultrasound of the nails, etc.). Since the nail is a complex biological tissue, mainly composes of hard α-keratins, the structural and morphological techniques can be used to analyze the human fingernails. The aim of this study was to corroborate the information obtained using Raman spectroscopy with those obtained by scanning electron microscopy (SEM) and X-ray diffractometry and to assess the potential of these techniques as non-invasive dermatologic diagnostic tools and an alternative to current methods.https://www.mdpi.com/1420-3049/26/2/280nail psoriasisRaman spectroscopyX-ray diffractionscanning electron microscopy (SEM) |
| spellingShingle | Anca E. Chiriac Doina Azoicai Adina Coroaba Florica Doroftei Daniel Timpu Anca Chiriac Mihaela Pertea Elena-Laura Ursu Mariana Pinteala Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails Molecules nail psoriasis Raman spectroscopy X-ray diffraction scanning electron microscopy (SEM) |
| title | Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails |
| title_full | Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails |
| title_fullStr | Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails |
| title_full_unstemmed | Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails |
| title_short | Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails |
| title_sort | raman spectroscopy x ray diffraction and scanning electron microscopy as noninvasive methods for microstructural alterations in psoriatic nails |
| topic | nail psoriasis Raman spectroscopy X-ray diffraction scanning electron microscopy (SEM) |
| url | https://www.mdpi.com/1420-3049/26/2/280 |
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