Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy
This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series o...
Main Authors: | Xiaosa Chang, Dejuan Sun, Danfeng Shi, Guan Wang, Yanmei Chen, Kai Zhang, Huidan Tan, Jie Liu, Bo Liu, Liang Ouyang |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
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Series: | Acta Pharmaceutica Sinica B |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383520305979 |
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