Whole-body x-ray dark-field radiography of a human cadaver
Abstract Background Grating-based x-ray dark-field and phase-contrast imaging allow extracting information about refraction and small-angle scatter, beyond conventional attenuation. A step towards clinical translation has recently been achieved, allowing further investigation on humans. Methods Afte...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-01-01
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| Series: | European Radiology Experimental |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41747-020-00201-1 |
| _version_ | 1818934385378852864 |
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| author | Jana Andrejewski Fabio De Marco Konstantin Willer Wolfgang Noichl Alex Gustschin Thomas Koehler Pascal Meyer Fabian Kriner Florian Fischer Christian Braun Alexander A. Fingerle Julia Herzen Franz Pfeiffer Daniela Pfeiffer |
| author_facet | Jana Andrejewski Fabio De Marco Konstantin Willer Wolfgang Noichl Alex Gustschin Thomas Koehler Pascal Meyer Fabian Kriner Florian Fischer Christian Braun Alexander A. Fingerle Julia Herzen Franz Pfeiffer Daniela Pfeiffer |
| author_sort | Jana Andrejewski |
| collection | DOAJ |
| description | Abstract Background Grating-based x-ray dark-field and phase-contrast imaging allow extracting information about refraction and small-angle scatter, beyond conventional attenuation. A step towards clinical translation has recently been achieved, allowing further investigation on humans. Methods After the ethics committee approval, we scanned the full body of a human cadaver in anterior-posterior orientation. Six measurements were stitched together to form the whole-body image. All radiographs were taken at a three-grating large-object x-ray dark-field scanner, each lasting about 40 s. Signal intensities of different anatomical regions were assessed. The magnitude of visibility reduction caused by beam hardening instead of small-angle scatter was analysed using different phantom materials. Maximal effective dose was 0.3 mSv for the abdomen. Results Combined attenuation and dark-field radiography are technically possible throughout a whole human body. High signal levels were found in several bony structures, foreign materials, and the lung. Signal levels were 0.25 ± 0.13 (mean ± standard deviation) for the lungs, 0.08 ± 0.06 for the bones, 0.023 ± 0.019 for soft tissue, and 0.30 ± 0.02 for an antibiotic bead chain. We found that phantom materials, which do not produce small-angle scatter, can generate a strong visibility reduction signal. Conclusion We acquired a whole-body x-ray dark-field radiograph of a human body in few minutes with an effective dose in a clinical acceptable range. Our findings suggest that the observed visibility reduction in the bone and metal is dominated by beam hardening and that the true dark-field signal in the lung is therefore much higher than that of the bone. |
| first_indexed | 2024-12-20T05:03:26Z |
| format | Article |
| id | doaj.art-a815fbd5bb824cde91ef88c2a8f0d980 |
| institution | Directory Open Access Journal |
| issn | 2509-9280 |
| language | English |
| last_indexed | 2024-12-20T05:03:26Z |
| publishDate | 2021-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Radiology Experimental |
| spelling | doaj.art-a815fbd5bb824cde91ef88c2a8f0d9802022-12-21T19:52:29ZengSpringerOpenEuropean Radiology Experimental2509-92802021-01-01511910.1186/s41747-020-00201-1Whole-body x-ray dark-field radiography of a human cadaverJana Andrejewski0Fabio De Marco1Konstantin Willer2Wolfgang Noichl3Alex Gustschin4Thomas Koehler5Pascal Meyer6Fabian Kriner7Florian Fischer8Christian Braun9Alexander A. Fingerle10Julia Herzen11Franz Pfeiffer12Daniela Pfeiffer13Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of MunichChair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of MunichChair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of MunichChair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of MunichChair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of MunichPhilips ResearchInstitute of Microstructure Technology, Karlsruhe Institute of TechnologyInstitut für Rechtsmedizin, Ludwig-Maximilians-Universität MünchenInstitut für Rechtsmedizin, Ludwig-Maximilians-Universität MünchenInstitut für Rechtsmedizin, Ludwig-Maximilians-Universität MünchenDepartment of Diagnostic and Interventional Radiology, Technical University of MunichChair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of MunichChair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of MunichDepartment of Diagnostic and Interventional Radiology, Technical University of MunichAbstract Background Grating-based x-ray dark-field and phase-contrast imaging allow extracting information about refraction and small-angle scatter, beyond conventional attenuation. A step towards clinical translation has recently been achieved, allowing further investigation on humans. Methods After the ethics committee approval, we scanned the full body of a human cadaver in anterior-posterior orientation. Six measurements were stitched together to form the whole-body image. All radiographs were taken at a three-grating large-object x-ray dark-field scanner, each lasting about 40 s. Signal intensities of different anatomical regions were assessed. The magnitude of visibility reduction caused by beam hardening instead of small-angle scatter was analysed using different phantom materials. Maximal effective dose was 0.3 mSv for the abdomen. Results Combined attenuation and dark-field radiography are technically possible throughout a whole human body. High signal levels were found in several bony structures, foreign materials, and the lung. Signal levels were 0.25 ± 0.13 (mean ± standard deviation) for the lungs, 0.08 ± 0.06 for the bones, 0.023 ± 0.019 for soft tissue, and 0.30 ± 0.02 for an antibiotic bead chain. We found that phantom materials, which do not produce small-angle scatter, can generate a strong visibility reduction signal. Conclusion We acquired a whole-body x-ray dark-field radiograph of a human body in few minutes with an effective dose in a clinical acceptable range. Our findings suggest that the observed visibility reduction in the bone and metal is dominated by beam hardening and that the true dark-field signal in the lung is therefore much higher than that of the bone.https://doi.org/10.1186/s41747-020-00201-1Dark-field imagingHuman bodyRadiographyWhole-body imagingX-rays |
| spellingShingle | Jana Andrejewski Fabio De Marco Konstantin Willer Wolfgang Noichl Alex Gustschin Thomas Koehler Pascal Meyer Fabian Kriner Florian Fischer Christian Braun Alexander A. Fingerle Julia Herzen Franz Pfeiffer Daniela Pfeiffer Whole-body x-ray dark-field radiography of a human cadaver European Radiology Experimental Dark-field imaging Human body Radiography Whole-body imaging X-rays |
| title | Whole-body x-ray dark-field radiography of a human cadaver |
| title_full | Whole-body x-ray dark-field radiography of a human cadaver |
| title_fullStr | Whole-body x-ray dark-field radiography of a human cadaver |
| title_full_unstemmed | Whole-body x-ray dark-field radiography of a human cadaver |
| title_short | Whole-body x-ray dark-field radiography of a human cadaver |
| title_sort | whole body x ray dark field radiography of a human cadaver |
| topic | Dark-field imaging Human body Radiography Whole-body imaging X-rays |
| url | https://doi.org/10.1186/s41747-020-00201-1 |
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