Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications
Abstract Background Studies have recently revealed that almost every type of cells including tumor cells abundantly release small vesicles known as extracellular vesicles (EVs) into the extracellular milieu. EVs carry a repertoire of biological molecules including nucleic acids, proteins, lipids, an...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12964-019-0390-y |
| _version_ | 1819087869319315456 |
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| author | Reza Rahbarghazi Nasrollah Jabbari Neda Abbaspour Sani Rahim Asghari Leila Salimi Sadegh Asghari Kalashani Maryam Feghhi Tahereh Etemadi Elinaz Akbariazar Mahmoud Mahmoudi Jafar Rezaie |
| author_facet | Reza Rahbarghazi Nasrollah Jabbari Neda Abbaspour Sani Rahim Asghari Leila Salimi Sadegh Asghari Kalashani Maryam Feghhi Tahereh Etemadi Elinaz Akbariazar Mahmoud Mahmoudi Jafar Rezaie |
| author_sort | Reza Rahbarghazi |
| collection | DOAJ |
| description | Abstract Background Studies have recently revealed that almost every type of cells including tumor cells abundantly release small vesicles known as extracellular vesicles (EVs) into the extracellular milieu. EVs carry a repertoire of biological molecules including nucleic acids, proteins, lipids, and carbohydrates and transport their cargo between cells in the vicinity as well as distantly located cells and hence act as messengers of intercellular communication. In this review, we aimed to discuss the tumor-derived exosome biology and the pivotal roles of exosomes in cancer diagnosis and treatment. Methods In the present review study, the authors studied several articles over the past two decades published on the kinetics of EVs in tumor environment as well as on the application of these vesicles in cancer diagnosis and therapy. Results A growing body of evidence indicates that nucleic acids such as microRNAs (miRNAs) transferring by EVs participate to create a conducive tumor environment. As EV-associated miRNAs are tissue-specific and present in most biological fluids, they hold great potential for clinical application in cancer early diagnosis, prognosis, and treatment response. Furthermore, exosomes can serve as drug delivery vehicles transferring miRNAs as well as therapeutic agents to target cells. These nano-vesicles exhibit ideal properties in comparison with the synthetic carriers that attracted scientist’s attention in the field of nanotechnology medicine. Scientists have employed different strategies to build exosomes-based drug delivery system. In general, two methods (direct engineering and indirect engineering) are being utilized to produce artificial exosomes. Para-clinical data have confirmed the beneficial effects of engineering exosomes in cancer therapy. Conclusion Exosomal miRNAs hold great promise for clinical application in early diagnosis and treatment of cancers. In addition, in spite of enthusiastic results obtained by engineered exosomes, however, there is an increasing concern over the use of optimal methods for engineering exosomes and the safety of engineered exosomes in clinical trials is still unclear. |
| first_indexed | 2024-12-21T21:43:00Z |
| format | Article |
| id | doaj.art-a81781b153a9429f9d6c6d710ce1c213 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-21T21:43:00Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-a81781b153a9429f9d6c6d710ce1c2132022-12-21T18:49:19ZengBMCCell Communication and Signaling1478-811X2019-07-0117111710.1186/s12964-019-0390-yTumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applicationsReza Rahbarghazi0Nasrollah Jabbari1Neda Abbaspour Sani2Rahim Asghari3Leila Salimi4Sadegh Asghari Kalashani5Maryam Feghhi6Tahereh Etemadi7Elinaz Akbariazar8Mahmoud Mahmoudi9Jafar Rezaie10Stem Cell Research Center, Tabriz University of Medical SciencesSolid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical SciencesSolid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical SciencesSolid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesDepartment of Medical Laboratory Sciences, Imam Khomeini hospital, Urmia University of Medical SciencesDepartment of Medical Physics and Imaging, Urmia University of Medical SciencesDepartment of biology, faculty of sciences, Arak UniversityDepartment of Genetic, Urmia University of Medical SciencesDepartment of Medical Parasitology, Urmia University of Medical SciencesSolid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical SciencesAbstract Background Studies have recently revealed that almost every type of cells including tumor cells abundantly release small vesicles known as extracellular vesicles (EVs) into the extracellular milieu. EVs carry a repertoire of biological molecules including nucleic acids, proteins, lipids, and carbohydrates and transport their cargo between cells in the vicinity as well as distantly located cells and hence act as messengers of intercellular communication. In this review, we aimed to discuss the tumor-derived exosome biology and the pivotal roles of exosomes in cancer diagnosis and treatment. Methods In the present review study, the authors studied several articles over the past two decades published on the kinetics of EVs in tumor environment as well as on the application of these vesicles in cancer diagnosis and therapy. Results A growing body of evidence indicates that nucleic acids such as microRNAs (miRNAs) transferring by EVs participate to create a conducive tumor environment. As EV-associated miRNAs are tissue-specific and present in most biological fluids, they hold great potential for clinical application in cancer early diagnosis, prognosis, and treatment response. Furthermore, exosomes can serve as drug delivery vehicles transferring miRNAs as well as therapeutic agents to target cells. These nano-vesicles exhibit ideal properties in comparison with the synthetic carriers that attracted scientist’s attention in the field of nanotechnology medicine. Scientists have employed different strategies to build exosomes-based drug delivery system. In general, two methods (direct engineering and indirect engineering) are being utilized to produce artificial exosomes. Para-clinical data have confirmed the beneficial effects of engineering exosomes in cancer therapy. Conclusion Exosomal miRNAs hold great promise for clinical application in early diagnosis and treatment of cancers. In addition, in spite of enthusiastic results obtained by engineered exosomes, however, there is an increasing concern over the use of optimal methods for engineering exosomes and the safety of engineered exosomes in clinical trials is still unclear.http://link.springer.com/article/10.1186/s12964-019-0390-yExtracellular vesiclesCancermiRNABiomarkerDrug delivery |
| spellingShingle | Reza Rahbarghazi Nasrollah Jabbari Neda Abbaspour Sani Rahim Asghari Leila Salimi Sadegh Asghari Kalashani Maryam Feghhi Tahereh Etemadi Elinaz Akbariazar Mahmoud Mahmoudi Jafar Rezaie Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications Cell Communication and Signaling Extracellular vesicles Cancer miRNA Biomarker Drug delivery |
| title | Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications |
| title_full | Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications |
| title_fullStr | Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications |
| title_full_unstemmed | Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications |
| title_short | Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications |
| title_sort | tumor derived extracellular vesicles reliable tools for cancer diagnosis and clinical applications |
| topic | Extracellular vesicles Cancer miRNA Biomarker Drug delivery |
| url | http://link.springer.com/article/10.1186/s12964-019-0390-y |
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