Three Binding Conformations of BIO124 in the Pocket of the PICK1 PDZ Domain

Three Binding Conformations of BIO124 in the Pocket of the PICK1 PDZ Domain

The PDZ family has drawn attention as possible drug targets because of the domains’ wide ranges of function and highly conserved binding pockets. The PICK1 PDZ domain has been proposed as a possible drug target because the interactions between the PICK1 PDZ domain and the GluA2 subunit of the AMPA r...

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Bibliographic Details
Main Authors: Amy O. Stevens, Samuel Luo, Yi He
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
PICK1
PDZ domain
BIO124
dynamic allosterism
Online Access:https://www.mdpi.com/2073-4409/11/15/2451

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