A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma
Recent studies have indicated that long non-coding RNAs (lncRNAs) may participate in the regulation of tumor cell proptosis. However, the connection between lncRNA expression and pyroptosis remains unclear in colon adenocarcinoma (COAD). This study aims to explore and establish a prognostic signatur...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-12-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.811734/full |
| _version_ | 1818574049988575232 |
|---|---|
| author | Fada Xia Yuanliang Yan Cong Shen Cong Shen |
| author_facet | Fada Xia Yuanliang Yan Cong Shen Cong Shen |
| author_sort | Fada Xia |
| collection | DOAJ |
| description | Recent studies have indicated that long non-coding RNAs (lncRNAs) may participate in the regulation of tumor cell proptosis. However, the connection between lncRNA expression and pyroptosis remains unclear in colon adenocarcinoma (COAD). This study aims to explore and establish a prognostic signature of COAD based on the pyroptosis-related lncRNAs. We identify 15 prognostic pyroptosis-related lncRNAs (ZNF667-AS1, OIP5-AS1, AL118506.1, AF117829.1, POC1B-AS1, CCDC18-AS1, THUMPD3-AS1, FLNB-AS1, SNHG11, HCG18, AL021707.2, UGDH-AS1, LINC00641, FGD5-AS1 and AC245452.1) from the TCGA-COAD dataset and use them to construct the risk model. After then, this pyroptosis-related lncRNA signature is validated in patients from the GSE17536 dataset. The COAD patients are divided into low-risk and high-risk groups by setting the median risk score as the cut-off point and represented differences in the immune microenvironment. Hence, we construct the immune risk model based on the infiltration levels of ssGSEA immune cells. Interestingly, the risk model and immune risk model are both independent prognostic risk factors. Therefore, a nomogram combined risk score, immune risk score with clinical information which is meaningful in univariate and multivariate Cox regression analysis is established to predict the overall survival (OS) of COAD patients. In general, the signature consisted of 15 pyroptosis-related lncRNAs and was proved to be associated with the immune landscape of COAD patients. |
| first_indexed | 2024-12-15T00:21:16Z |
| format | Article |
| id | doaj.art-a8182199eb48467482e0d0787f41c374 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-15T00:21:16Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a8182199eb48467482e0d0787f41c3742022-12-21T22:42:18ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-12-01910.3389/fcell.2021.811734811734A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon AdenocarcinomaFada Xia0Yuanliang Yan1Cong Shen2Cong Shen3Center for Molecular Medicine, Xiangya Hospital, Key Laboratory of Molecular Radiation Oncology of Hunan Province, Central South University, Changsha, ChinaCenter for Molecular Medicine, Xiangya Hospital, Key Laboratory of Molecular Radiation Oncology of Hunan Province, Central South University, Changsha, ChinaCenter for Molecular Medicine, Xiangya Hospital, Key Laboratory of Molecular Radiation Oncology of Hunan Province, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaRecent studies have indicated that long non-coding RNAs (lncRNAs) may participate in the regulation of tumor cell proptosis. However, the connection between lncRNA expression and pyroptosis remains unclear in colon adenocarcinoma (COAD). This study aims to explore and establish a prognostic signature of COAD based on the pyroptosis-related lncRNAs. We identify 15 prognostic pyroptosis-related lncRNAs (ZNF667-AS1, OIP5-AS1, AL118506.1, AF117829.1, POC1B-AS1, CCDC18-AS1, THUMPD3-AS1, FLNB-AS1, SNHG11, HCG18, AL021707.2, UGDH-AS1, LINC00641, FGD5-AS1 and AC245452.1) from the TCGA-COAD dataset and use them to construct the risk model. After then, this pyroptosis-related lncRNA signature is validated in patients from the GSE17536 dataset. The COAD patients are divided into low-risk and high-risk groups by setting the median risk score as the cut-off point and represented differences in the immune microenvironment. Hence, we construct the immune risk model based on the infiltration levels of ssGSEA immune cells. Interestingly, the risk model and immune risk model are both independent prognostic risk factors. Therefore, a nomogram combined risk score, immune risk score with clinical information which is meaningful in univariate and multivariate Cox regression analysis is established to predict the overall survival (OS) of COAD patients. In general, the signature consisted of 15 pyroptosis-related lncRNAs and was proved to be associated with the immune landscape of COAD patients.https://www.frontiersin.org/articles/10.3389/fcell.2021.811734/fullpyroptosislncRNAcolon adenocarcinoma (COAD)immune microenvironmentprognosis |
| spellingShingle | Fada Xia Yuanliang Yan Cong Shen Cong Shen A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma Frontiers in Cell and Developmental Biology pyroptosis lncRNA colon adenocarcinoma (COAD) immune microenvironment prognosis |
| title | A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma |
| title_full | A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma |
| title_fullStr | A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma |
| title_full_unstemmed | A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma |
| title_short | A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma |
| title_sort | prognostic pyroptosis related lncrnas risk model correlates with the immune microenvironment in colon adenocarcinoma |
| topic | pyroptosis lncRNA colon adenocarcinoma (COAD) immune microenvironment prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.811734/full |
| work_keys_str_mv | AT fadaxia aprognosticpyroptosisrelatedlncrnasriskmodelcorrelateswiththeimmunemicroenvironmentincolonadenocarcinoma AT yuanliangyan aprognosticpyroptosisrelatedlncrnasriskmodelcorrelateswiththeimmunemicroenvironmentincolonadenocarcinoma AT congshen aprognosticpyroptosisrelatedlncrnasriskmodelcorrelateswiththeimmunemicroenvironmentincolonadenocarcinoma AT congshen aprognosticpyroptosisrelatedlncrnasriskmodelcorrelateswiththeimmunemicroenvironmentincolonadenocarcinoma AT fadaxia prognosticpyroptosisrelatedlncrnasriskmodelcorrelateswiththeimmunemicroenvironmentincolonadenocarcinoma AT yuanliangyan prognosticpyroptosisrelatedlncrnasriskmodelcorrelateswiththeimmunemicroenvironmentincolonadenocarcinoma AT congshen prognosticpyroptosisrelatedlncrnasriskmodelcorrelateswiththeimmunemicroenvironmentincolonadenocarcinoma AT congshen prognosticpyroptosisrelatedlncrnasriskmodelcorrelateswiththeimmunemicroenvironmentincolonadenocarcinoma |