Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD)
PurposeTo verify the International Chronic Ocular Graft-Versus-Host Disease (ICCGVHD) Group diagnostic criteria and establish an easy-to-use and reliable diagnosis model for quick identification of chronic oGVHD.MethodsThis study included 180 patients (355 eyes) who underwent allogeneic hematopoieti...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1277194/full |
| _version_ | 1797647637285961728 |
|---|---|
| author | Zhan Shen Zhan Shen Bohao Hu Bohao Hu Liyuan Tao Jiao Ma Jiao Ma Rongmei Peng Rongmei Peng Yinghan Zhao Yinghan Zhao Jing Hong Jing Hong |
| author_facet | Zhan Shen Zhan Shen Bohao Hu Bohao Hu Liyuan Tao Jiao Ma Jiao Ma Rongmei Peng Rongmei Peng Yinghan Zhao Yinghan Zhao Jing Hong Jing Hong |
| author_sort | Zhan Shen |
| collection | DOAJ |
| description | PurposeTo verify the International Chronic Ocular Graft-Versus-Host Disease (ICCGVHD) Group diagnostic criteria and establish an easy-to-use and reliable diagnosis model for quick identification of chronic oGVHD.MethodsThis study included 180 patients (355 eyes) who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and visited the Peking University Third Hospital Cornea and Ocular Surface Disease Specialist Clinic from July 2020 to February 2021. The proportion of chronic oGVHD was 76.06% (279/355).ResultsFive complaints, including eye dryness, photophobia, foreign body sensation, eye redness, and burning sensation; six ophthalmic examinations, including Ocular Surface Disease Index (OSDI) score, corneal fluorescein staining (CFS), tear break-up time (TBUT), Schirmer’s test score without anesthesia, conjunctival score, tear meniscus height, and non-ocular GVHD-involved organs were significantly different between patients with chronic oGVHD and control group (p < 0.05). Binary logistic regression (backward LR algorithm) selection demonstrated that three variables retained diagnostic significance for chronic oGVHD: CFS (OR = 2.71 (1.92–3.81), p < 0.001), Schirmer’s test score without anesthesia (OR = 0.83 (0.76–0.91), p < 0.001), and conjunctival score (OR = 1.96 (1.13–3.42), p = 0.031). A nomogram for the identification of chronic oGVHD was developed, and its performance was examined using an internal validation cohort (118 eyes). The areas under the curve (AUCs) for the three-variable-based nomogram were 0.976 (95% CI (0.959–0.992), p < 0.01) and 0.945 (95% CI (0.904–0.986), p < 0.01) in the development and internal validation cohorts, respectively.ConclusionThis concise three-variable-based nomogram based on ICCGVHD criteria could serve as an easy-to-use and reliable tool for rapid screening of chronic oGVHD. |
| first_indexed | 2024-03-11T15:20:21Z |
| format | Article |
| id | doaj.art-a818aca8a81747dda0ac9f9131b778fe |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-11T15:20:21Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-a818aca8a81747dda0ac9f9131b778fe2023-10-28T21:34:24ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-10-011010.3389/fmed.2023.12771941277194Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD)Zhan Shen0Zhan Shen1Bohao Hu2Bohao Hu3Liyuan Tao4Jiao Ma5Jiao Ma6Rongmei Peng7Rongmei Peng8Yinghan Zhao9Yinghan Zhao10Jing Hong11Jing Hong12Department of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaResearch Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaPurposeTo verify the International Chronic Ocular Graft-Versus-Host Disease (ICCGVHD) Group diagnostic criteria and establish an easy-to-use and reliable diagnosis model for quick identification of chronic oGVHD.MethodsThis study included 180 patients (355 eyes) who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and visited the Peking University Third Hospital Cornea and Ocular Surface Disease Specialist Clinic from July 2020 to February 2021. The proportion of chronic oGVHD was 76.06% (279/355).ResultsFive complaints, including eye dryness, photophobia, foreign body sensation, eye redness, and burning sensation; six ophthalmic examinations, including Ocular Surface Disease Index (OSDI) score, corneal fluorescein staining (CFS), tear break-up time (TBUT), Schirmer’s test score without anesthesia, conjunctival score, tear meniscus height, and non-ocular GVHD-involved organs were significantly different between patients with chronic oGVHD and control group (p < 0.05). Binary logistic regression (backward LR algorithm) selection demonstrated that three variables retained diagnostic significance for chronic oGVHD: CFS (OR = 2.71 (1.92–3.81), p < 0.001), Schirmer’s test score without anesthesia (OR = 0.83 (0.76–0.91), p < 0.001), and conjunctival score (OR = 1.96 (1.13–3.42), p = 0.031). A nomogram for the identification of chronic oGVHD was developed, and its performance was examined using an internal validation cohort (118 eyes). The areas under the curve (AUCs) for the three-variable-based nomogram were 0.976 (95% CI (0.959–0.992), p < 0.01) and 0.945 (95% CI (0.904–0.986), p < 0.01) in the development and internal validation cohorts, respectively.ConclusionThis concise three-variable-based nomogram based on ICCGVHD criteria could serve as an easy-to-use and reliable tool for rapid screening of chronic oGVHD.https://www.frontiersin.org/articles/10.3389/fmed.2023.1277194/fullChronic Ocular Graft-Versus-Host Diseasecorneal fluorescein stainingdiagnostic modelnomogramSchirmer’s tear test |
| spellingShingle | Zhan Shen Zhan Shen Bohao Hu Bohao Hu Liyuan Tao Jiao Ma Jiao Ma Rongmei Peng Rongmei Peng Yinghan Zhao Yinghan Zhao Jing Hong Jing Hong Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD) Frontiers in Medicine Chronic Ocular Graft-Versus-Host Disease corneal fluorescein staining diagnostic model nomogram Schirmer’s tear test |
| title | Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD) |
| title_full | Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD) |
| title_fullStr | Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD) |
| title_full_unstemmed | Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD) |
| title_short | Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD) |
| title_sort | development and validation of a diagnostic model for the identification of chronic ocular graft versus host disease ogvhd |
| topic | Chronic Ocular Graft-Versus-Host Disease corneal fluorescein staining diagnostic model nomogram Schirmer’s tear test |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1277194/full |
| work_keys_str_mv | AT zhanshen developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT zhanshen developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT bohaohu developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT bohaohu developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT liyuantao developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT jiaoma developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT jiaoma developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT rongmeipeng developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT rongmeipeng developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT yinghanzhao developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT yinghanzhao developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT jinghong developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd AT jinghong developmentandvalidationofadiagnosticmodelfortheidentificationofchronicoculargraftversushostdiseaseogvhd |