Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice

Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice

An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence i...

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Bibliographic Details
Main Authors: Andrea N. Loes, Lauren E. Gentles, Allison J. Greaney, Katharine H. D. Crawford, Jesse D. Bloom
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
SARS-CoV-2
influenza
intranasal
live attenuated vaccine
spike
RBD
Online Access:https://www.mdpi.com/1999-4915/12/9/987

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