Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigs
ABSTRACT: Streptococcus suis is a Gram-positive pathogen that inhabits the upper respiratory tract and can cause severe systemic inflammatory disease in pigs, mainly during the nursery phase. Streptococcus suis is a reemergent pathogen, and outbreaks of its inducing disease represent significant eco...
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| Format: | Article |
| Language: | English |
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Colégio Brasileiro de Patologia Animal (CBPA)
2022-11-01
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| Series: | Pesquisa Veterinária Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2022000100240&tlng=en |
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| author | Márcia E. Hammerschmitt Claiton I. Schwertz Bruna C. Lopes Paula R. Pereira Rafael Frandoloso David Driemeier |
| author_facet | Márcia E. Hammerschmitt Claiton I. Schwertz Bruna C. Lopes Paula R. Pereira Rafael Frandoloso David Driemeier |
| author_sort | Márcia E. Hammerschmitt |
| collection | DOAJ |
| description | ABSTRACT: Streptococcus suis is a Gram-positive pathogen that inhabits the upper respiratory tract and can cause severe systemic inflammatory disease in pigs, mainly during the nursery phase. Streptococcus suis is a reemergent pathogen, and outbreaks of its inducing disease represent significant economic losses for the pig industry worldwide. In this study, we described the clinical, pathological, and molecular aspects of an outbreak of S. suis infection with atypically high mortality. The outbreak occurred in nursery farms integrated into a cooperative in the state of Paraná, Brazil. Of the 30 nurseries, 10 were severely affected by the pathogen and had high economic losses. Clinical signs usually started approximately 10 days after weaning and were mainly characterized by acute nervous and locomotor disorders. The mortality of the affected batches usually ranged between 8% and 10%, but in some cases, it reached 18%. Nine piglets were submitted to post mortem examination. Macroscopically, the synovial joints were enlarged and contained fibrinous exudates. In the central nervous system, there was hyperemia of the leptomeningeal vessels associated with deposition of fibrin and purulent exudate in the leptomeninges. In three piglets, there was thickening of the choroid plexus associated with dilation of the lateral ventricles. Microscopic lesions were characterized mainly by fibrinosuppurative inflammation, which involved the synovial membranes, leptomeninges of the brain, and spinal cord. Furthermore, it also affects the choroid plexus, ependyma, nerve roots, and central canal of the spinal cord. S. suis was isolated from the cerebrospinal fluid, meningeal swabs, and/or synovial fluid of 8/9 piglets, and typified as serotype 9 by multiplex PCR. |
| first_indexed | 2024-04-11T17:45:44Z |
| format | Article |
| id | doaj.art-a81d228133e342a1a08d7b6f004eb969 |
| institution | Directory Open Access Journal |
| issn | 1678-5150 |
| language | English |
| last_indexed | 2025-03-21T08:27:20Z |
| publishDate | 2022-11-01 |
| publisher | Colégio Brasileiro de Patologia Animal (CBPA) |
| record_format | Article |
| series | Pesquisa Veterinária Brasileira |
| spelling | doaj.art-a81d228133e342a1a08d7b6f004eb9692024-07-12T12:10:22ZengColégio Brasileiro de Patologia Animal (CBPA)Pesquisa Veterinária Brasileira1678-51502022-11-014210.1590/1678-5150-pvb-7004Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigsMárcia E. Hammerschmitthttps://orcid.org/0000-0002-4990-5412Claiton I. Schwertzhttps://orcid.org/0000-0002-5285-7896Bruna C. LopesPaula R. Pereirahttps://orcid.org/0000-0001-7658-3562Rafael FrandolosoDavid Driemeierhttps://orcid.org/0000-0003-3766-0654ABSTRACT: Streptococcus suis is a Gram-positive pathogen that inhabits the upper respiratory tract and can cause severe systemic inflammatory disease in pigs, mainly during the nursery phase. Streptococcus suis is a reemergent pathogen, and outbreaks of its inducing disease represent significant economic losses for the pig industry worldwide. In this study, we described the clinical, pathological, and molecular aspects of an outbreak of S. suis infection with atypically high mortality. The outbreak occurred in nursery farms integrated into a cooperative in the state of Paraná, Brazil. Of the 30 nurseries, 10 were severely affected by the pathogen and had high economic losses. Clinical signs usually started approximately 10 days after weaning and were mainly characterized by acute nervous and locomotor disorders. The mortality of the affected batches usually ranged between 8% and 10%, but in some cases, it reached 18%. Nine piglets were submitted to post mortem examination. Macroscopically, the synovial joints were enlarged and contained fibrinous exudates. In the central nervous system, there was hyperemia of the leptomeningeal vessels associated with deposition of fibrin and purulent exudate in the leptomeninges. In three piglets, there was thickening of the choroid plexus associated with dilation of the lateral ventricles. Microscopic lesions were characterized mainly by fibrinosuppurative inflammation, which involved the synovial membranes, leptomeninges of the brain, and spinal cord. Furthermore, it also affects the choroid plexus, ependyma, nerve roots, and central canal of the spinal cord. S. suis was isolated from the cerebrospinal fluid, meningeal swabs, and/or synovial fluid of 8/9 piglets, and typified as serotype 9 by multiplex PCR.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2022000100240&tlng=enSwine diseasesnervous systemmeningitischoroiditisencephalomyelitisspinal cordStreptococcus suispigs |
| spellingShingle | Márcia E. Hammerschmitt Claiton I. Schwertz Bruna C. Lopes Paula R. Pereira Rafael Frandoloso David Driemeier Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigs Pesquisa Veterinária Brasileira Swine diseases nervous system meningitis choroiditis encephalomyelitis spinal cord Streptococcus suis pigs |
| title | Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigs |
| title_full | Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigs |
| title_fullStr | Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigs |
| title_full_unstemmed | Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigs |
| title_short | Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigs |
| title_sort | clinical and pathological aspects of an outbreak of streptococcus suis serotype 9 infection in pigs |
| topic | Swine diseases nervous system meningitis choroiditis encephalomyelitis spinal cord Streptococcus suis pigs |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2022000100240&tlng=en |
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