INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View
Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/12/2172 |
| _version_ | 1797505550135590912 |
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| author | Zahra Maleki Akash Nadella Mohnish Nadella Gopi Patel Shivni Patel Ivana Kholová |
| author_facet | Zahra Maleki Akash Nadella Mohnish Nadella Gopi Patel Shivni Patel Ivana Kholová |
| author_sort | Zahra Maleki |
| collection | DOAJ |
| description | Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1′s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears). |
| first_indexed | 2024-03-10T04:20:11Z |
| format | Article |
| id | doaj.art-a81e37372d974a4ea392ac34c05e6496 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:20:11Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-a81e37372d974a4ea392ac34c05e64962023-11-23T07:52:25ZengMDPI AGDiagnostics2075-44182021-11-011112217210.3390/diagnostics11122172INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ ViewZahra Maleki0Akash Nadella1Mohnish Nadella2Gopi Patel3Shivni Patel4Ivana Kholová5Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, The Johns Hopkins Medical Institution, Baltimore, MD 21218, USADepartment of Pathology, Johns Hopkins University, Baltimore, MD 21218, USADepartment of Pathology, Johns Hopkins University, Baltimore, MD 21218, USADepartment of Pathology, Johns Hopkins University, Baltimore, MD 21218, USADepartment of Pathology, Johns Hopkins University, Baltimore, MD 21218, USADepartment of Pathology, Fimlab Laboratories, Tampere, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, FinlandBackground: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1′s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears).https://www.mdpi.com/2075-4418/11/12/2172cytologyneuroendocrine tumorINSM-1 immunostainingmedullary thyroid carcinomapancreatic neuroendocrine tumorpulmonary neuroendocrine neoplasms |
| spellingShingle | Zahra Maleki Akash Nadella Mohnish Nadella Gopi Patel Shivni Patel Ivana Kholová INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View Diagnostics cytology neuroendocrine tumor INSM-1 immunostaining medullary thyroid carcinoma pancreatic neuroendocrine tumor pulmonary neuroendocrine neoplasms |
| title | INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View |
| title_full | INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View |
| title_fullStr | INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View |
| title_full_unstemmed | INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View |
| title_short | INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View |
| title_sort | insm1 a novel biomarker for detection of neuroendocrine neoplasms cytopathologists view |
| topic | cytology neuroendocrine tumor INSM-1 immunostaining medullary thyroid carcinoma pancreatic neuroendocrine tumor pulmonary neuroendocrine neoplasms |
| url | https://www.mdpi.com/2075-4418/11/12/2172 |
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