Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based Cohort
The objective of the current study was to assess the relationship of bone marrow adipose tissue (BMAT) content to abdominal fat depots, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), as well as cardiovascular risk factors (CVRF) beyond physical activity in a populatio...
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1527 |
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| author | Dunja Hasic Roberto Lorbeer Robert C. Bertheau Jürgen Machann Susanne Rospleszcz Johanna Nattenmüller Wolfgang Rathmann Annette Peters Fabian Bamberg Christopher L. Schlett |
| author_facet | Dunja Hasic Roberto Lorbeer Robert C. Bertheau Jürgen Machann Susanne Rospleszcz Johanna Nattenmüller Wolfgang Rathmann Annette Peters Fabian Bamberg Christopher L. Schlett |
| author_sort | Dunja Hasic |
| collection | DOAJ |
| description | The objective of the current study was to assess the relationship of bone marrow adipose tissue (BMAT) content to abdominal fat depots, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), as well as cardiovascular risk factors (CVRF) beyond physical activity in a population-based cohort study undergoing whole-body magnetic resonance (MR) imaging. Subjects of the Cooperative Health Research in the Augsburg Region (KORA) FF4 study without known cardiovascular disease underwent fat fraction quantification in vertebrae (BMAT<sub>L1/L2</sub>) via a 2-point T1-weighted volumetric interpolated breath-hold examination (VIBE) Dixon sequence. The same MR sequence was applied to quantify VAT and SAT volume. Subjects’ characteristics, including physical activity, were determined through standardized exams and self-assessment questionnaires. Univariate and multivariate linear regression were applied. In the cohort of 378 subjects (56 ± 9.1years; 42.1% female), BMAT<sub>L1/L2</sub> was 54.3 ± 10.1%, VAT was 4.54 ± 2.71 L, and SAT was 8.10 ± 3.68 L. VAT differed significantly across BMAT<sub>L1/L2</sub> tertiles (3.60 ± 2.76 vs. 4.92 ± 2.66 vs. 5.11 ± 2.48; <i>p</i> < 0.001), there was no significant differences for SAT (<i>p</i> = 0.39). In the fully adjusted model, VAT remained positively associated with BMAT<sub>L1/L2</sub> (β = 0.53, <i>p</i> = 0.03). Furthermore, BMAT<sub>L1/L2</sub> was associated with age (β = 5.40 per 10-years, <i>p</i> < 0.001), hemoglobin A1c (HbA1c; β = 1.55 per 1%, <i>p</i> = 0.04), lipids (β = 0.20 per 10 mg/dL triglycerides; β = 0.40 per 10 mg/dL low-density lipoprotein (LDL); β =−3.21 lipid-lowering medication; all <i>p</i> < 0.05), and less physical activity (β = 3.7 “no or nearly no exercise” as compared to “≥2 h per week, regularly”, <i>p</i> = 0.003); gender was not significantly different (<i>p</i> = 0.57). In the population-based cohort, VAT but not SAT were associated with higher BMAT<sub>L1/L2</sub> independently of physical activity and other cardiovascular risk factors. Further, BMAT<sub>L1/L2</sub> increased with older age, less physical activity, higher HbA1c, and increased lipids but decreased with lipid-lowering medication. |
| first_indexed | 2024-03-10T19:37:56Z |
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| language | English |
| last_indexed | 2024-03-10T19:37:56Z |
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| series | Nutrients |
| spelling | doaj.art-a81e9e06439b483cbc37db9192359dad2023-11-20T01:32:51ZengMDPI AGNutrients2072-66432020-05-01125152710.3390/nu12051527Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based CohortDunja Hasic0Roberto Lorbeer1Robert C. Bertheau2Jürgen Machann3Susanne Rospleszcz4Johanna Nattenmüller5Wolfgang Rathmann6Annette Peters7Fabian Bamberg8Christopher L. Schlett9Department of Diagnostic and Interventional Radiology, Medical Center - Faculty of Medicine, University of Freiburg, 79085 Freiburg, GermanyDepartment of Radiology, Ludwig-Maximilian-University Hospital, 80539 Munich, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Heidelberg, 69117 Heidelberg, GermanyInstitute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tuebingen, 72072 Tuebingen, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Heidelberg, 69117 Heidelberg, GermanyDepartment of Biometry and Epidemiology, German Diabetes Center, 40225 Düsseldorf, GermanyGerman Center for Cardiovascular Disease Research (DZHK e.V.), 20251 Munich, GermanyDepartment of Diagnostic and Interventional Radiology, Medical Center - Faculty of Medicine, University of Freiburg, 79085 Freiburg, GermanyDepartment of Diagnostic and Interventional Radiology, Medical Center - Faculty of Medicine, University of Freiburg, 79085 Freiburg, GermanyThe objective of the current study was to assess the relationship of bone marrow adipose tissue (BMAT) content to abdominal fat depots, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), as well as cardiovascular risk factors (CVRF) beyond physical activity in a population-based cohort study undergoing whole-body magnetic resonance (MR) imaging. Subjects of the Cooperative Health Research in the Augsburg Region (KORA) FF4 study without known cardiovascular disease underwent fat fraction quantification in vertebrae (BMAT<sub>L1/L2</sub>) via a 2-point T1-weighted volumetric interpolated breath-hold examination (VIBE) Dixon sequence. The same MR sequence was applied to quantify VAT and SAT volume. Subjects’ characteristics, including physical activity, were determined through standardized exams and self-assessment questionnaires. Univariate and multivariate linear regression were applied. In the cohort of 378 subjects (56 ± 9.1years; 42.1% female), BMAT<sub>L1/L2</sub> was 54.3 ± 10.1%, VAT was 4.54 ± 2.71 L, and SAT was 8.10 ± 3.68 L. VAT differed significantly across BMAT<sub>L1/L2</sub> tertiles (3.60 ± 2.76 vs. 4.92 ± 2.66 vs. 5.11 ± 2.48; <i>p</i> < 0.001), there was no significant differences for SAT (<i>p</i> = 0.39). In the fully adjusted model, VAT remained positively associated with BMAT<sub>L1/L2</sub> (β = 0.53, <i>p</i> = 0.03). Furthermore, BMAT<sub>L1/L2</sub> was associated with age (β = 5.40 per 10-years, <i>p</i> < 0.001), hemoglobin A1c (HbA1c; β = 1.55 per 1%, <i>p</i> = 0.04), lipids (β = 0.20 per 10 mg/dL triglycerides; β = 0.40 per 10 mg/dL low-density lipoprotein (LDL); β =−3.21 lipid-lowering medication; all <i>p</i> < 0.05), and less physical activity (β = 3.7 “no or nearly no exercise” as compared to “≥2 h per week, regularly”, <i>p</i> = 0.003); gender was not significantly different (<i>p</i> = 0.57). In the population-based cohort, VAT but not SAT were associated with higher BMAT<sub>L1/L2</sub> independently of physical activity and other cardiovascular risk factors. Further, BMAT<sub>L1/L2</sub> increased with older age, less physical activity, higher HbA1c, and increased lipids but decreased with lipid-lowering medication.https://www.mdpi.com/2072-6643/12/5/1527magnetic resonance imagingbone marrowvisceral adipose tissuesubcutaneous adipose tissuemetabolic disease |
| spellingShingle | Dunja Hasic Roberto Lorbeer Robert C. Bertheau Jürgen Machann Susanne Rospleszcz Johanna Nattenmüller Wolfgang Rathmann Annette Peters Fabian Bamberg Christopher L. Schlett Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based Cohort Nutrients magnetic resonance imaging bone marrow visceral adipose tissue subcutaneous adipose tissue metabolic disease |
| title | Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based Cohort |
| title_full | Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based Cohort |
| title_fullStr | Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based Cohort |
| title_full_unstemmed | Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based Cohort |
| title_short | Vertebral Bone Marrow Fat Is independently Associated to VAT but Not to SAT: KORA FF4—Whole-Body MR Imaging in a Population-Based Cohort |
| title_sort | vertebral bone marrow fat is independently associated to vat but not to sat kora ff4 whole body mr imaging in a population based cohort |
| topic | magnetic resonance imaging bone marrow visceral adipose tissue subcutaneous adipose tissue metabolic disease |
| url | https://www.mdpi.com/2072-6643/12/5/1527 |
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