Effect of treating <it>Schistosoma haematobium </it>infection on <it>Plasmodium falciparum-specific </it>antibody responses
<p>Abstract</p> <p>Background</p> <p>The overlapping geographical and socio-economic distribution of malaria and helminth infection has led to several studies investigating the immunological and pathological interactions of these parasites. This study focuses on the eff...
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| Format: | Article |
| Language: | English |
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BMC
2008-11-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/8/158 |
| _version_ | 1818081172620574720 |
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| author | Mduluza T Cavanagh DR Magkrioti C Reilly L Mutapi F |
| author_facet | Mduluza T Cavanagh DR Magkrioti C Reilly L Mutapi F |
| author_sort | Mduluza T |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The overlapping geographical and socio-economic distribution of malaria and helminth infection has led to several studies investigating the immunological and pathological interactions of these parasites. This study focuses on the effect of treating schistosome infections on natural human immune responses directed against plasmodia merozoite surface proteins MSP-1 (DPKMWR, MSP1<sub>19</sub>), and MSP-2 (CH150 and Dd2) which are potential vaccine candidates as well as crude malaria (schizont) and schistosome (whole worm homogenate) proteins.</p> <p>Methods</p> <p>IgG1 and IgG3 antibody responses directed against <it>Schistosoma haematobium </it>crude adult worm antigen (WWH) and <it>Plasmodium falciparum </it>antigens (merozoite surface proteins 1/2 and schizont extract), were measured by enzyme linked immunosorbent assay (ELISA) in 117 Zimbabweans (6–18 years old) exposed to <it>S. haematobium </it>and <it>P. falciparum </it>infection. These responses were measured before and after anti-helminth treatment with praziquantel to determine the effects of treatment on anti-plasmodial/schistosome responses.</p> <p>Results</p> <p>There were no significant associations between antibody responses (IgG1/IgG3) directed against <it>P. falciparum </it>and schistosomes before treatment. Six weeks after schistosome treatment there were significant changes in levels of IgG1 directed against schistosome crude antigens, plasmodia crude antigens, MSP-1<sub>19</sub>, MSP-2 (Dd2), and in IgG3 directed against MSP-1<sub>19</sub>. However, only changes in anti-schistosome IgG1 were attributable to the anti-helminth treatment.</p> <p>Conclusion</p> <p>There was no association between anti-<it>P. falciparum </it>and <it>S. haematobium antibody </it>responses in this population and <it>a</it>nti-helminth treatment affected only anti-schistosome responses and not responses against plasmodia crude antigens or MSP-1 and -2 vaccine candidates.</p> |
| first_indexed | 2024-12-10T19:01:59Z |
| format | Article |
| id | doaj.art-a8231071500d484a8721fabf4f5e937f |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-10T19:01:59Z |
| publishDate | 2008-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-a8231071500d484a8721fabf4f5e937f2022-12-22T01:36:59ZengBMCBMC Infectious Diseases1471-23342008-11-018115810.1186/1471-2334-8-158Effect of treating <it>Schistosoma haematobium </it>infection on <it>Plasmodium falciparum-specific </it>antibody responsesMduluza TCavanagh DRMagkrioti CReilly LMutapi F<p>Abstract</p> <p>Background</p> <p>The overlapping geographical and socio-economic distribution of malaria and helminth infection has led to several studies investigating the immunological and pathological interactions of these parasites. This study focuses on the effect of treating schistosome infections on natural human immune responses directed against plasmodia merozoite surface proteins MSP-1 (DPKMWR, MSP1<sub>19</sub>), and MSP-2 (CH150 and Dd2) which are potential vaccine candidates as well as crude malaria (schizont) and schistosome (whole worm homogenate) proteins.</p> <p>Methods</p> <p>IgG1 and IgG3 antibody responses directed against <it>Schistosoma haematobium </it>crude adult worm antigen (WWH) and <it>Plasmodium falciparum </it>antigens (merozoite surface proteins 1/2 and schizont extract), were measured by enzyme linked immunosorbent assay (ELISA) in 117 Zimbabweans (6–18 years old) exposed to <it>S. haematobium </it>and <it>P. falciparum </it>infection. These responses were measured before and after anti-helminth treatment with praziquantel to determine the effects of treatment on anti-plasmodial/schistosome responses.</p> <p>Results</p> <p>There were no significant associations between antibody responses (IgG1/IgG3) directed against <it>P. falciparum </it>and schistosomes before treatment. Six weeks after schistosome treatment there were significant changes in levels of IgG1 directed against schistosome crude antigens, plasmodia crude antigens, MSP-1<sub>19</sub>, MSP-2 (Dd2), and in IgG3 directed against MSP-1<sub>19</sub>. However, only changes in anti-schistosome IgG1 were attributable to the anti-helminth treatment.</p> <p>Conclusion</p> <p>There was no association between anti-<it>P. falciparum </it>and <it>S. haematobium antibody </it>responses in this population and <it>a</it>nti-helminth treatment affected only anti-schistosome responses and not responses against plasmodia crude antigens or MSP-1 and -2 vaccine candidates.</p>http://www.biomedcentral.com/1471-2334/8/158 |
| spellingShingle | Mduluza T Cavanagh DR Magkrioti C Reilly L Mutapi F Effect of treating <it>Schistosoma haematobium </it>infection on <it>Plasmodium falciparum-specific </it>antibody responses BMC Infectious Diseases |
| title | Effect of treating <it>Schistosoma haematobium </it>infection on <it>Plasmodium falciparum-specific </it>antibody responses |
| title_full | Effect of treating <it>Schistosoma haematobium </it>infection on <it>Plasmodium falciparum-specific </it>antibody responses |
| title_fullStr | Effect of treating <it>Schistosoma haematobium </it>infection on <it>Plasmodium falciparum-specific </it>antibody responses |
| title_full_unstemmed | Effect of treating <it>Schistosoma haematobium </it>infection on <it>Plasmodium falciparum-specific </it>antibody responses |
| title_short | Effect of treating <it>Schistosoma haematobium </it>infection on <it>Plasmodium falciparum-specific </it>antibody responses |
| title_sort | effect of treating it schistosoma haematobium it infection on it plasmodium falciparum specific it antibody responses |
| url | http://www.biomedcentral.com/1471-2334/8/158 |
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