More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer
Human breast milk (HBM) is an irreplaceable source of nutrition for early infant growth and development. Breast-fed children are known to have a low prevalence and reduced risk of various diseases, such as necrotizing enterocolitis, gastroenteritis, acute lymphocytic leukemia, and acute myeloid leuk...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/19/7327 |
| _version_ | 1797551850997678080 |
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| author | Ki-Uk Kim Wan-Hoon Kim Chi Hwan Jeong Dae Yong Yi Hyeyoung Min |
| author_facet | Ki-Uk Kim Wan-Hoon Kim Chi Hwan Jeong Dae Yong Yi Hyeyoung Min |
| author_sort | Ki-Uk Kim |
| collection | DOAJ |
| description | Human breast milk (HBM) is an irreplaceable source of nutrition for early infant growth and development. Breast-fed children are known to have a low prevalence and reduced risk of various diseases, such as necrotizing enterocolitis, gastroenteritis, acute lymphocytic leukemia, and acute myeloid leukemia. In recent years, HBM has been found to contain a microbiome, extracellular vesicles or exosomes, and microRNAs, as well as nutritional components and non-nutritional proteins, including immunoregulatory proteins, hormones, and growth factors. Especially, the milk-derived exosomes exert various physiological and therapeutic function in cell proliferation, inflammation, immunomodulation, and cancer, which are mainly attributed to their cargo molecules such as proteins and microRNAs. The exosomal miRNAs are protected from enzymatic digestion and acidic conditions, and play a critical role in immune regulation and cancer. In addition, the milk-derived exosomes are developed as drug carriers for delivering small molecules and siRNA to tumor sites. In this review, we examined the various components of HBM and their therapeutic potential, in particular of exosomes and microRNAs, towards cancer. |
| first_indexed | 2024-03-10T15:50:56Z |
| format | Article |
| id | doaj.art-a823f90175a1415fab58e2b34a0c8b47 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:50:56Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a823f90175a1415fab58e2b34a0c8b472023-11-20T16:01:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012119732710.3390/ijms21197327More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in CancerKi-Uk Kim0Wan-Hoon Kim1Chi Hwan Jeong2Dae Yong Yi3Hyeyoung Min4College of Pharmacy, Chung-Ang University, Seoul 06974, KoreaCollege of Pharmacy, Chung-Ang University, Seoul 06974, KoreaCollege of Pharmacy, Chung-Ang University, Seoul 06974, KoreaDepartment of Pediatrics, Chung-Ang University College of Medicine, Seoul 06974, KoreaCollege of Pharmacy, Chung-Ang University, Seoul 06974, KoreaHuman breast milk (HBM) is an irreplaceable source of nutrition for early infant growth and development. Breast-fed children are known to have a low prevalence and reduced risk of various diseases, such as necrotizing enterocolitis, gastroenteritis, acute lymphocytic leukemia, and acute myeloid leukemia. In recent years, HBM has been found to contain a microbiome, extracellular vesicles or exosomes, and microRNAs, as well as nutritional components and non-nutritional proteins, including immunoregulatory proteins, hormones, and growth factors. Especially, the milk-derived exosomes exert various physiological and therapeutic function in cell proliferation, inflammation, immunomodulation, and cancer, which are mainly attributed to their cargo molecules such as proteins and microRNAs. The exosomal miRNAs are protected from enzymatic digestion and acidic conditions, and play a critical role in immune regulation and cancer. In addition, the milk-derived exosomes are developed as drug carriers for delivering small molecules and siRNA to tumor sites. In this review, we examined the various components of HBM and their therapeutic potential, in particular of exosomes and microRNAs, towards cancer.https://www.mdpi.com/1422-0067/21/19/7327human milknutrientmicrobiotaexosomesmicroRNAscancer |
| spellingShingle | Ki-Uk Kim Wan-Hoon Kim Chi Hwan Jeong Dae Yong Yi Hyeyoung Min More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer International Journal of Molecular Sciences human milk nutrient microbiota exosomes microRNAs cancer |
| title | More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer |
| title_full | More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer |
| title_fullStr | More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer |
| title_full_unstemmed | More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer |
| title_short | More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer |
| title_sort | more than nutrition therapeutic potential of breast milk derived exosomes in cancer |
| topic | human milk nutrient microbiota exosomes microRNAs cancer |
| url | https://www.mdpi.com/1422-0067/21/19/7327 |
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