A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy
Antiphospholipid syndrome (APS) is an acquired autoimmune clinical disorder characterized by persistently raised levels of anti-phospholipid antibodies and clinical feature of hypercoagulability (recurrent vascular thrombosis and pregnancy morbidities). Primary APS is idiopathic in nature though sec...
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| Format: | Article |
| Language: | English |
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KIMS Foundation and Research Center
2022-06-01
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| Series: | Journal of Medical and Scientific Research |
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| Online Access: | http://jmsronline.com/archive-article/Antiphospholipid-antibody-syndrome-cerebral-venous-sinus-thrombosis-epilepsy |
| _version_ | 1811173109723561984 |
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| author | Tanwar VS Singh AA Tank R Saini A Jatana S Singh S |
| author_facet | Tanwar VS Singh AA Tank R Saini A Jatana S Singh S |
| author_sort | Tanwar VS |
| collection | DOAJ |
| description | Antiphospholipid syndrome (APS) is an acquired autoimmune clinical disorder characterized by persistently raised levels of anti-phospholipid antibodies and clinical feature of hypercoagulability (recurrent vascular thrombosis and pregnancy morbidities). Primary APS is idiopathic in nature though secondary APS is associated with other connective tissue diseases like SLE. Here, we present an instance of primary APS with recurrent cerebral venous sinus thrombosis in a youthful unmarried female who clinically presented with generalized epilepsy. Level of anti-cardiolipin (aCL) and anti-beta 2 GP1 antibodies were found elevated on two occasions 12 weeks apart. The patient was treated with anticoagulation therapy along with anti-epileptic therapy and she responded well to the therapy. This case report highlights that clinicians should always suspect APS in female patients who had history of seizures and ischemic or thrombotic lesions on brain imaging, irrespective of presence of pregnancy comorbidities. |
| first_indexed | 2024-04-10T17:42:25Z |
| format | Article |
| id | doaj.art-a82464ce96114868afc0c7f279823239 |
| institution | Directory Open Access Journal |
| issn | 2321-1326 2394-112X |
| language | English |
| last_indexed | 2024-04-10T17:42:25Z |
| publishDate | 2022-06-01 |
| publisher | KIMS Foundation and Research Center |
| record_format | Article |
| series | Journal of Medical and Scientific Research |
| spelling | doaj.art-a82464ce96114868afc0c7f2798232392023-02-03T11:32:25ZengKIMS Foundation and Research CenterJournal of Medical and Scientific Research2321-13262394-112X2022-06-0110210510810.17727/JMSR.2022/10-20A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsyTanwar VS0Singh AA1Tank R2Saini A3Jatana S4Singh S5Department of Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar-122107, India Department of Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar-122107, India Department of Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar-122107, India Department of Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar-122107, India Department of Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar-122107, India Department of Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar-122107, India Antiphospholipid syndrome (APS) is an acquired autoimmune clinical disorder characterized by persistently raised levels of anti-phospholipid antibodies and clinical feature of hypercoagulability (recurrent vascular thrombosis and pregnancy morbidities). Primary APS is idiopathic in nature though secondary APS is associated with other connective tissue diseases like SLE. Here, we present an instance of primary APS with recurrent cerebral venous sinus thrombosis in a youthful unmarried female who clinically presented with generalized epilepsy. Level of anti-cardiolipin (aCL) and anti-beta 2 GP1 antibodies were found elevated on two occasions 12 weeks apart. The patient was treated with anticoagulation therapy along with anti-epileptic therapy and she responded well to the therapy. This case report highlights that clinicians should always suspect APS in female patients who had history of seizures and ischemic or thrombotic lesions on brain imaging, irrespective of presence of pregnancy comorbidities. http://jmsronline.com/archive-article/Antiphospholipid-antibody-syndrome-cerebral-venous-sinus-thrombosis-epilepsyantiphospholipid syndromecerebral venoussinus thrombosisepilepsy |
| spellingShingle | Tanwar VS Singh AA Tank R Saini A Jatana S Singh S A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy Journal of Medical and Scientific Research antiphospholipid syndrome cerebral venous sinus thrombosis epilepsy |
| title | A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy |
| title_full | A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy |
| title_fullStr | A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy |
| title_full_unstemmed | A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy |
| title_short | A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy |
| title_sort | case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy |
| topic | antiphospholipid syndrome cerebral venous sinus thrombosis epilepsy |
| url | http://jmsronline.com/archive-article/Antiphospholipid-antibody-syndrome-cerebral-venous-sinus-thrombosis-epilepsy |
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