The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport
The pleiotropic serine/threonine protein kinase CK2 was the first kinase discovered. It is renowned for its role in cell proliferation and anti-apoptosis. The complexity of this kinase is well reflected by the findings of past decades in terms of its heterotetrameric structure, subcellular location,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | http://www.mdpi.com/1424-8247/9/4/80 |
| _version_ | 1818199152535797760 |
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| author | Adam J. Johnson Ming J. Wu |
| author_facet | Adam J. Johnson Ming J. Wu |
| author_sort | Adam J. Johnson |
| collection | DOAJ |
| description | The pleiotropic serine/threonine protein kinase CK2 was the first kinase discovered. It is renowned for its role in cell proliferation and anti-apoptosis. The complexity of this kinase is well reflected by the findings of past decades in terms of its heterotetrameric structure, subcellular location, constitutive activity and the extensive catalogue of substrates. With the advent of non-biased high-throughput functional genomics such as genome-wide deletion mutant screening, novel aspects of CK2 functionality have been revealed. Our recent discoveries using the model organism Saccharomyces cerevisiae and mammalian cells demonstrate that CK2 regulates metal toxicity. Extensive literature search reveals that there are few but elegant works on the role of CK2 in regulating the sodium and zinc channels. As both CK2 and metal ions are key players in cell biology and oncogenesis, understanding the details of CK2’s regulation of metal ion homeostasis has a direct bearing on cancer research. In this review, we aim to garner the recent data and gain insights into the role of CK2 in metal ion transport. |
| first_indexed | 2024-12-12T02:17:13Z |
| format | Article |
| id | doaj.art-a82617604a4e4e31bc7adc32b2a62c3f |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-12T02:17:13Z |
| publishDate | 2016-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-a82617604a4e4e31bc7adc32b2a62c3f2022-12-22T00:41:47ZengMDPI AGPharmaceuticals1424-82472016-12-01948010.3390/ph9040080ph9040080The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion TransportAdam J. Johnson0Ming J. Wu1School of Science and Health, Western Sydney University, Locked Bag 1797, Penrith NSW 2751, AustraliaSchool of Science and Health, Western Sydney University, Locked Bag 1797, Penrith NSW 2751, AustraliaThe pleiotropic serine/threonine protein kinase CK2 was the first kinase discovered. It is renowned for its role in cell proliferation and anti-apoptosis. The complexity of this kinase is well reflected by the findings of past decades in terms of its heterotetrameric structure, subcellular location, constitutive activity and the extensive catalogue of substrates. With the advent of non-biased high-throughput functional genomics such as genome-wide deletion mutant screening, novel aspects of CK2 functionality have been revealed. Our recent discoveries using the model organism Saccharomyces cerevisiae and mammalian cells demonstrate that CK2 regulates metal toxicity. Extensive literature search reveals that there are few but elegant works on the role of CK2 in regulating the sodium and zinc channels. As both CK2 and metal ions are key players in cell biology and oncogenesis, understanding the details of CK2’s regulation of metal ion homeostasis has a direct bearing on cancer research. In this review, we aim to garner the recent data and gain insights into the role of CK2 in metal ion transport.http://www.mdpi.com/1424-8247/9/4/80protein kinase CK2metal toxicitygenome-wide screenmetal ion transportzinc channelstherapeutic targets |
| spellingShingle | Adam J. Johnson Ming J. Wu The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport Pharmaceuticals protein kinase CK2 metal toxicity genome-wide screen metal ion transport zinc channels therapeutic targets |
| title | The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport |
| title_full | The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport |
| title_fullStr | The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport |
| title_full_unstemmed | The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport |
| title_short | The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport |
| title_sort | new role for an old kinase protein kinase ck2 regulates metal ion transport |
| topic | protein kinase CK2 metal toxicity genome-wide screen metal ion transport zinc channels therapeutic targets |
| url | http://www.mdpi.com/1424-8247/9/4/80 |
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