Clonal abundance patterns in hematopoiesis: Mathematical modeling and parameter estimation

Clonal abundance patterns in hematopoiesis: Mathematical modeling and parameter estimation

Hematopoiesis has been studied via stem cell labeling using barcodes, viral integration sites (VISs), or in situ methods. Subsequent proliferation and differentiation preserve the tag identity, thus defining a clone of mature cells across multiple cell type or lineages. By tracking the population of...

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Bibliographic Details
Main Authors: Yunbei Pan, Maria R. D’Orsogna, Min Tang, Thomas Stiehl, Tom Chou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Systems Biology
Subjects:
stem cells
hematopoiesis
barcodes
clonal tracking
differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fsysb.2023.893366/full

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