A case of non-palpable, multifocal, heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcifications
Introduction. In 2018, the number of newly diagnosed breast carcinomas in the 28 countries of the European Union was 404 920, with an estimated annual incidence of 144.9/100 000. Figures have increased since the introduction of mammography screening and continue to rise with population aging. Mammog...
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Balkan Medical Union
2020-09-01
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| Series: | Archives of the Balkan Medical Union |
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| Online Access: | https://umbalk.org/wp-content/uploads/2020/09/15.A-CASE-OF-NON%E2%80%91PALPABLE-MULTIFOCAL-HETEROGENEOUS.pdf |
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| author | Vasil D. NANEV Liana G. TONEVA Angel D. YORDANOV Strahil A. STRASHILOV Ivan N. IVANOV |
| author_facet | Vasil D. NANEV Liana G. TONEVA Angel D. YORDANOV Strahil A. STRASHILOV Ivan N. IVANOV |
| author_sort | Vasil D. NANEV |
| collection | DOAJ |
| description | Introduction. In 2018, the number of newly diagnosed breast carcinomas in the 28 countries of the European Union was 404 920, with an estimated annual incidence of 144.9/100 000. Figures have increased since the introduction of mammography screening and continue to rise with population aging. Mammograms may convey clinically occult breast cancer, which is associated in some cases with the presence of clustered microcalcifications.
Case presentation. We present the case of a 64-year-old patient with multifocal invasive ductal left breast cancer and lobular carcinoma in situ, diagnosed after biopsy of a mammogram-marked area with clustered microcalcifications. The patient underwent subsequent radical surgical treatment.
Conclusions. Clustered microcalcifications on mammograms may indicate clinically occult breast cancer. These lesions cause clinical and diagnostic difficulties due to the inability of ultrasound visualisation and the option to perform punch biopsy, as recommended by European Society for Medical Oncology. Excision biopsy by mammography-guided wire marking and pathological-anatomical examination of the entire resectate can detect tumour heterogeneity, which is important for the subsequent therapeutic strategy and prognosis of the disease. |
| first_indexed | 2024-12-10T23:52:25Z |
| format | Article |
| id | doaj.art-a8280266be814ba09d0c9a66f4a0e68b |
| institution | Directory Open Access Journal |
| issn | 1584-9244 2558-815X |
| language | English |
| last_indexed | 2024-12-10T23:52:25Z |
| publishDate | 2020-09-01 |
| publisher | Balkan Medical Union |
| record_format | Article |
| series | Archives of the Balkan Medical Union |
| spelling | doaj.art-a8280266be814ba09d0c9a66f4a0e68b2022-12-22T01:28:42ZengBalkan Medical UnionArchives of the Balkan Medical Union1584-92442558-815X2020-09-01553489494http://doi.org/10.31688/ABMU.2020.55.3.15A case of non-palpable, multifocal, heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcificationsVasil D. NANEV0Liana G. TONEVA1Angel D. YORDANOV2Strahil A. STRASHILOV3Ivan N. IVANOV4 Department of Surgical Oncology, University Hospital „Dr. Georgi Stranski“, Medical University Pleven, Pleven, BulgariaDepartment of Radiology, University Hospital „Dr. Georgi Stranski“, Medical University Pleven, Pleven, BulgariaClinic of Gynecologic Oncology, University Hospital „Dr. Georgi Stranski“, Medical University Pleven, Pleven, BulgariaDepartment of Plastic Restorative, Reconstructive and Aesthetic Surgery, University Hospital „Dr. Georgi Stranski“, Medical University Pleven, Pleven, Bulgaria Department of Clinical Pathology, University Hospital „Dr. Georgi Stranski“, Medical University Pleven, Pleven, BulgariaIntroduction. In 2018, the number of newly diagnosed breast carcinomas in the 28 countries of the European Union was 404 920, with an estimated annual incidence of 144.9/100 000. Figures have increased since the introduction of mammography screening and continue to rise with population aging. Mammograms may convey clinically occult breast cancer, which is associated in some cases with the presence of clustered microcalcifications. Case presentation. We present the case of a 64-year-old patient with multifocal invasive ductal left breast cancer and lobular carcinoma in situ, diagnosed after biopsy of a mammogram-marked area with clustered microcalcifications. The patient underwent subsequent radical surgical treatment. Conclusions. Clustered microcalcifications on mammograms may indicate clinically occult breast cancer. These lesions cause clinical and diagnostic difficulties due to the inability of ultrasound visualisation and the option to perform punch biopsy, as recommended by European Society for Medical Oncology. Excision biopsy by mammography-guided wire marking and pathological-anatomical examination of the entire resectate can detect tumour heterogeneity, which is important for the subsequent therapeutic strategy and prognosis of the disease.https://umbalk.org/wp-content/uploads/2020/09/15.A-CASE-OF-NON%E2%80%91PALPABLE-MULTIFOCAL-HETEROGENEOUS.pdfclustered microcalcificationsmammography-guided metallic markerheterogeneity of mammary gland tumour |
| spellingShingle | Vasil D. NANEV Liana G. TONEVA Angel D. YORDANOV Strahil A. STRASHILOV Ivan N. IVANOV A case of non-palpable, multifocal, heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcifications Archives of the Balkan Medical Union clustered microcalcifications mammography-guided metallic marker heterogeneity of mammary gland tumour |
| title | A case of non-palpable, multifocal, heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcifications |
| title_full | A case of non-palpable, multifocal, heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcifications |
| title_fullStr | A case of non-palpable, multifocal, heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcifications |
| title_full_unstemmed | A case of non-palpable, multifocal, heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcifications |
| title_short | A case of non-palpable, multifocal, heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcifications |
| title_sort | case of non palpable multifocal heterogeneous left breast carcinoma with mammographic presentation of clustered multiple microcalcifications |
| topic | clustered microcalcifications mammography-guided metallic marker heterogeneity of mammary gland tumour |
| url | https://umbalk.org/wp-content/uploads/2020/09/15.A-CASE-OF-NON%E2%80%91PALPABLE-MULTIFOCAL-HETEROGENEOUS.pdf |
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