Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19
Abstract Coronavirus disease 19 (COVID-19) patients usually require long periods of mechanical ventilation and sedation, which added to steroid therapy, favours a predisposition to the development of delirium and subsequent mental health disorders, as well as physical and respiratory sequelae. The a...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11929-8 |
| _version_ | 1811253263018754048 |
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| author | Kapil Nanwani-Nanwani Lorenzo López-Pérez Carola Giménez-Esparza Inés Ruiz-Barranco Elena Carrillo María Soledad Arellano Domingo Díaz-Díaz Beatriz Hurtado Andoni García-Muñoz María Ángeles Relucio Manuel Quintana-Díaz María Rosario Úrbez Andrés Saravia María Victoria Bonan Francisco García-Río María Luisa Testillano Jesús Villar Abelardo García de Lorenzo José Manuel Añón |
| author_facet | Kapil Nanwani-Nanwani Lorenzo López-Pérez Carola Giménez-Esparza Inés Ruiz-Barranco Elena Carrillo María Soledad Arellano Domingo Díaz-Díaz Beatriz Hurtado Andoni García-Muñoz María Ángeles Relucio Manuel Quintana-Díaz María Rosario Úrbez Andrés Saravia María Victoria Bonan Francisco García-Río María Luisa Testillano Jesús Villar Abelardo García de Lorenzo José Manuel Añón |
| author_sort | Kapil Nanwani-Nanwani |
| collection | DOAJ |
| description | Abstract Coronavirus disease 19 (COVID-19) patients usually require long periods of mechanical ventilation and sedation, which added to steroid therapy, favours a predisposition to the development of delirium and subsequent mental health disorders, as well as physical and respiratory sequelae. The aim of this study was to determine the prevalence of post-intensive care syndrome (PICS) at 3 months after hospital discharge, in a cohort of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ambispective, observational study was conducted in three hospitals with intensive care unit (ICU) follow-up clinics. We studied adults who survived a critical illness due to SARS-CoV-2 infection requiring invasive mechanical ventilation. A physical (muscle strength and pulmonary function), functional [12-Item Short Form Health Survey (SF-12), and Barthel score], psychological [hospital anxiety and depression (HADS) and posttraumatic stress disorder symptom severity scales], and cognitive [Montreal cognitive assessment (MoCA) test] assessment were performed. A total of 186 patients were evaluated at 88 days (IQR 68–121) after hospital discharge. Mean age was 59 ± 12 years old, 126 (68%) patients were men, and median length of mechanical ventilation was 14 days (IQR 8–31). About 3 out of 4 patients (n = 139, 75%) met PICS criteria. Symptoms of cognitive and psychiatric disorders were found in 59 (32%) and 58 (31%) patients, respectively. Ninety-one (49%) patients had muscle weakness. Pulmonary function tests in patients with no respiratory comorbidities showed a normal pattern in 93 (50%) patients, and a restrictive disorder in 62 (33%) patients. Also, 69 patients (37%) were on sick leave, while 32 (17%) had resumed work at the time of assessment. In conclusion, survivors of critical illness due to SARS-CoV-2 infection requiring mechanical ventilation have a high prevalence of PICS. Physical domain is the most frequently damaged, followed by cognitive and psychiatric disorders. ICU follow-up clinics enable the assistance of this vulnerable population. |
| first_indexed | 2024-04-12T16:48:20Z |
| format | Article |
| id | doaj.art-a828ffc13d0540eea63bcd254d4b4634 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:48:20Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a828ffc13d0540eea63bcd254d4b46342022-12-22T03:24:31ZengNature PortfolioScientific Reports2045-23222022-05-0112111110.1038/s41598-022-11929-8Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19Kapil Nanwani-Nanwani0Lorenzo López-Pérez1Carola Giménez-Esparza2Inés Ruiz-Barranco3Elena Carrillo4María Soledad Arellano5Domingo Díaz-Díaz6Beatriz Hurtado7Andoni García-Muñoz8María Ángeles Relucio9Manuel Quintana-Díaz10María Rosario Úrbez11Andrés Saravia12María Victoria Bonan13Francisco García-Río14María Luisa Testillano15Jesús Villar16Abelardo García de Lorenzo17José Manuel Añón18Intensive Care Unit, Hospital Universitario La PazIntensive Care Unit, Hospital Universitario Infanta LeonorIntensive Care Unit, Hospital Vega BajaIntensive Care Unit, Hospital Universitario La PazIntensive Care Unit, Hospital Universitario La PazIntensive Care Unit, Hospital Universitario La PazIntensive Care Unit, Hospital Universitario Infanta LeonorIntensive Care Unit, Hospital Vega BajaIntensive Care Unit, Hospital Universitario La PazIntensive Care Unit, Hospital Vega BajaIntensive Care Unit, Hospital Universitario La PazDepartment of Physical Medicine and Rehabilitation, Hospital Universitario La PazIntensive Care Unit, Hospital Universitario La PazDepartment of Psychiatry, Hospital Universitario La PazInstituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ)Department of Pharmacy, Hospital Universitario La PazCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos IIIIntensive Care Unit, Hospital Universitario La PazIntensive Care Unit, Hospital Universitario La PazAbstract Coronavirus disease 19 (COVID-19) patients usually require long periods of mechanical ventilation and sedation, which added to steroid therapy, favours a predisposition to the development of delirium and subsequent mental health disorders, as well as physical and respiratory sequelae. The aim of this study was to determine the prevalence of post-intensive care syndrome (PICS) at 3 months after hospital discharge, in a cohort of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ambispective, observational study was conducted in three hospitals with intensive care unit (ICU) follow-up clinics. We studied adults who survived a critical illness due to SARS-CoV-2 infection requiring invasive mechanical ventilation. A physical (muscle strength and pulmonary function), functional [12-Item Short Form Health Survey (SF-12), and Barthel score], psychological [hospital anxiety and depression (HADS) and posttraumatic stress disorder symptom severity scales], and cognitive [Montreal cognitive assessment (MoCA) test] assessment were performed. A total of 186 patients were evaluated at 88 days (IQR 68–121) after hospital discharge. Mean age was 59 ± 12 years old, 126 (68%) patients were men, and median length of mechanical ventilation was 14 days (IQR 8–31). About 3 out of 4 patients (n = 139, 75%) met PICS criteria. Symptoms of cognitive and psychiatric disorders were found in 59 (32%) and 58 (31%) patients, respectively. Ninety-one (49%) patients had muscle weakness. Pulmonary function tests in patients with no respiratory comorbidities showed a normal pattern in 93 (50%) patients, and a restrictive disorder in 62 (33%) patients. Also, 69 patients (37%) were on sick leave, while 32 (17%) had resumed work at the time of assessment. In conclusion, survivors of critical illness due to SARS-CoV-2 infection requiring mechanical ventilation have a high prevalence of PICS. Physical domain is the most frequently damaged, followed by cognitive and psychiatric disorders. ICU follow-up clinics enable the assistance of this vulnerable population.https://doi.org/10.1038/s41598-022-11929-8 |
| spellingShingle | Kapil Nanwani-Nanwani Lorenzo López-Pérez Carola Giménez-Esparza Inés Ruiz-Barranco Elena Carrillo María Soledad Arellano Domingo Díaz-Díaz Beatriz Hurtado Andoni García-Muñoz María Ángeles Relucio Manuel Quintana-Díaz María Rosario Úrbez Andrés Saravia María Victoria Bonan Francisco García-Río María Luisa Testillano Jesús Villar Abelardo García de Lorenzo José Manuel Añón Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19 Scientific Reports |
| title | Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19 |
| title_full | Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19 |
| title_fullStr | Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19 |
| title_full_unstemmed | Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19 |
| title_short | Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19 |
| title_sort | prevalence of post intensive care syndrome in mechanically ventilated patients with covid 19 |
| url | https://doi.org/10.1038/s41598-022-11929-8 |
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