Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic Review
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gut that can lead to severe gastrointestinal symptoms, malnutrition, and complications such as fistulas and cancer. Mesenchymal stem/stromal cells (MSCs) are being investigated as a novel therapy for IBD and have been demonst...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/1/82 |
| _version_ | 1797413256242921472 |
|---|---|
| author | Jeffrey Zheng-Hsien Ko Sheeva Johnson Maneesh Dave |
| author_facet | Jeffrey Zheng-Hsien Ko Sheeva Johnson Maneesh Dave |
| author_sort | Jeffrey Zheng-Hsien Ko |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gut that can lead to severe gastrointestinal symptoms, malnutrition, and complications such as fistulas and cancer. Mesenchymal stem/stromal cells (MSCs) are being investigated as a novel therapy for IBD and have been demonstrated to be safe and effective for perianal fistulizing Crohn’s disease (PFCD). This systematic review aims to present the most recent studies on the safety and efficacy of MSC therapy in IBD. A detailed search strategy of clinical trials on MSCs and IBD was performed on PubMed, with 32 studies selected for inclusion in this review. The newest studies on local MSC injection for PFCD continue to support long-term efficacy while maintaining a favorable safety profile. The evidence for systemic MSC infusion in luminal IBD remains mixed due to marked methodological heterogeneity and unclear safety profiles. Although further studies are needed to better establish the role of this novel treatment modality, MSCs are proving to be a very exciting addition to the limited therapies available for IBD. |
| first_indexed | 2024-03-09T05:15:11Z |
| format | Article |
| id | doaj.art-a82a4226e4214b769cf34701bb344c65 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T05:15:11Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-a82a4226e4214b769cf34701bb344c652023-12-03T12:46:39ZengMDPI AGBiomolecules2218-273X2021-01-011118210.3390/biom11010082Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic ReviewJeffrey Zheng-Hsien Ko0Sheeva Johnson1Maneesh Dave2Department of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, UC Davis School of Medicine, 4150 V Street, Suite 3500, Sacramento, CA 95817, USADepartment of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, UC Davis School of Medicine, 4150 V Street, Suite 3500, Sacramento, CA 95817, USADepartment of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, UC Davis School of Medicine, 4150 V Street, Suite 3500, Sacramento, CA 95817, USAInflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gut that can lead to severe gastrointestinal symptoms, malnutrition, and complications such as fistulas and cancer. Mesenchymal stem/stromal cells (MSCs) are being investigated as a novel therapy for IBD and have been demonstrated to be safe and effective for perianal fistulizing Crohn’s disease (PFCD). This systematic review aims to present the most recent studies on the safety and efficacy of MSC therapy in IBD. A detailed search strategy of clinical trials on MSCs and IBD was performed on PubMed, with 32 studies selected for inclusion in this review. The newest studies on local MSC injection for PFCD continue to support long-term efficacy while maintaining a favorable safety profile. The evidence for systemic MSC infusion in luminal IBD remains mixed due to marked methodological heterogeneity and unclear safety profiles. Although further studies are needed to better establish the role of this novel treatment modality, MSCs are proving to be a very exciting addition to the limited therapies available for IBD.https://www.mdpi.com/2218-273X/11/1/82inflammatory bowel diseaseCrohn’s diseaseulcerative colitisperianal fistulamesenchymal stem/stromal cellsefficacy |
| spellingShingle | Jeffrey Zheng-Hsien Ko Sheeva Johnson Maneesh Dave Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic Review Biomolecules inflammatory bowel disease Crohn’s disease ulcerative colitis perianal fistula mesenchymal stem/stromal cells efficacy |
| title | Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic Review |
| title_full | Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic Review |
| title_fullStr | Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic Review |
| title_full_unstemmed | Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic Review |
| title_short | Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic Review |
| title_sort | efficacy and safety of mesenchymal stem stromal cell therapy for inflammatory bowel diseases an up to date systematic review |
| topic | inflammatory bowel disease Crohn’s disease ulcerative colitis perianal fistula mesenchymal stem/stromal cells efficacy |
| url | https://www.mdpi.com/2218-273X/11/1/82 |
| work_keys_str_mv | AT jeffreyzhenghsienko efficacyandsafetyofmesenchymalstemstromalcelltherapyforinflammatoryboweldiseasesanuptodatesystematicreview AT sheevajohnson efficacyandsafetyofmesenchymalstemstromalcelltherapyforinflammatoryboweldiseasesanuptodatesystematicreview AT maneeshdave efficacyandsafetyofmesenchymalstemstromalcelltherapyforinflammatoryboweldiseasesanuptodatesystematicreview |