Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis
Abstract Background In the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to define the early bone changes occurring in axial spondyloarthritis (axSpA) a...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-018-1620-1 |
| _version_ | 1811240534681845760 |
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| author | Anna Neumann Judith Haschka Arnd Kleyer Louis Schuster Matthias Englbrecht Andreas Berlin Camille P. Figueiredo David Simon Christian Muschitz Roland Kocijan Heinrich Resch Jürgen Rech Georg Schett |
| author_facet | Anna Neumann Judith Haschka Arnd Kleyer Louis Schuster Matthias Englbrecht Andreas Berlin Camille P. Figueiredo David Simon Christian Muschitz Roland Kocijan Heinrich Resch Jürgen Rech Georg Schett |
| author_sort | Anna Neumann |
| collection | DOAJ |
| description | Abstract Background In the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to define the early bone changes occurring in axial spondyloarthritis (axSpA) and to define potential factors for deterioration of bone microstructure. Methods Patients with axSpA (n = 107) and healthy control subjects (n = 50) of similar age and sex were assessed for geometric, volumetric, and microstructural parameters of bone using high-resolution peripheral quantitative computed tomography (HR-pQCT) at the radius. Additionally, demographic and disease-specific characteristics of patients with axSpA were recorded. Results Patients with nr-axSpA and control subjects were comparable in age, sex, and body mass index. Geometric and microstructural analysis by HR-pQCT revealed a significantly reduced cortical area (p = 0.022) and cortical thickness (p = 0.006) in patients with nr-axSpA compared with control subjects. Total and cortical vBMD were significantly reduced in patients with nr-axSpA (p = 0.042 and p = 0.007, respectively), whereas there was no difference in trabecular vBMD. Patients with a short disease duration (< 2 years; n = 46) also showed significant reduction of cortical thickness and cortical area compared with control subjects. Patients with disease duration > 2 years (n = 55) additionally developed a decrease of cortical and total vBMD. Multiple regression models identified male sex to be associated with lower cortical vBMD and female sex to be associated with lower trabecular vBMD. Conclusions Bone microstructure in patients with nr-axSpA is characterized primarily by deterioration of cortical bone. Cortical bone loss starts early and is evident within the first 2 years of the disease. |
| first_indexed | 2024-04-12T13:22:02Z |
| format | Article |
| id | doaj.art-a82a4f08d45548bc8f1a1a8cc8e50153 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-12T13:22:02Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-a82a4f08d45548bc8f1a1a8cc8e501532022-12-22T03:31:27ZengBMCArthritis Research & Therapy1478-63622018-08-0120111110.1186/s13075-018-1620-1Cortical bone loss is an early feature of nonradiographic axial spondyloarthritisAnna Neumann0Judith Haschka1Arnd Kleyer2Louis Schuster3Matthias Englbrecht4Andreas Berlin5Camille P. Figueiredo6David Simon7Christian Muschitz8Roland Kocijan9Heinrich Resch10Jürgen Rech11Georg Schett12Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenSt. Vincent Hospital, VINFORCE Study Group, Medical University of ViennaSt. Vincent Hospital, VINFORCE Study Group, Medical University of ViennaSt. Vincent Hospital, VINFORCE Study Group, Medical University of ViennaDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich Alexander University Erlangen-Nurnberg and Universitätsklinikum ErlangenAbstract Background In the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to define the early bone changes occurring in axial spondyloarthritis (axSpA) and to define potential factors for deterioration of bone microstructure. Methods Patients with axSpA (n = 107) and healthy control subjects (n = 50) of similar age and sex were assessed for geometric, volumetric, and microstructural parameters of bone using high-resolution peripheral quantitative computed tomography (HR-pQCT) at the radius. Additionally, demographic and disease-specific characteristics of patients with axSpA were recorded. Results Patients with nr-axSpA and control subjects were comparable in age, sex, and body mass index. Geometric and microstructural analysis by HR-pQCT revealed a significantly reduced cortical area (p = 0.022) and cortical thickness (p = 0.006) in patients with nr-axSpA compared with control subjects. Total and cortical vBMD were significantly reduced in patients with nr-axSpA (p = 0.042 and p = 0.007, respectively), whereas there was no difference in trabecular vBMD. Patients with a short disease duration (< 2 years; n = 46) also showed significant reduction of cortical thickness and cortical area compared with control subjects. Patients with disease duration > 2 years (n = 55) additionally developed a decrease of cortical and total vBMD. Multiple regression models identified male sex to be associated with lower cortical vBMD and female sex to be associated with lower trabecular vBMD. Conclusions Bone microstructure in patients with nr-axSpA is characterized primarily by deterioration of cortical bone. Cortical bone loss starts early and is evident within the first 2 years of the disease.http://link.springer.com/article/10.1186/s13075-018-1620-1SpondyloarthritisBone lossComputed tomography |
| spellingShingle | Anna Neumann Judith Haschka Arnd Kleyer Louis Schuster Matthias Englbrecht Andreas Berlin Camille P. Figueiredo David Simon Christian Muschitz Roland Kocijan Heinrich Resch Jürgen Rech Georg Schett Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis Arthritis Research & Therapy Spondyloarthritis Bone loss Computed tomography |
| title | Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis |
| title_full | Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis |
| title_fullStr | Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis |
| title_full_unstemmed | Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis |
| title_short | Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis |
| title_sort | cortical bone loss is an early feature of nonradiographic axial spondyloarthritis |
| topic | Spondyloarthritis Bone loss Computed tomography |
| url | http://link.springer.com/article/10.1186/s13075-018-1620-1 |
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