Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Many survivors of serious COVID‐19 pneumonia have long‐term residual pulmonary disease. However, there is little documentation of the histopathological characteristi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
|
| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.871 |
| _version_ | 1818721415426211840 |
|---|---|
| author | Keishi Sugino Hirotaka Ono Shuji Haraguchi Seiji Igarashi Akira Hebisawa Eiyasu Tsuboi |
| author_facet | Keishi Sugino Hirotaka Ono Shuji Haraguchi Seiji Igarashi Akira Hebisawa Eiyasu Tsuboi |
| author_sort | Keishi Sugino |
| collection | DOAJ |
| description | Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Many survivors of serious COVID‐19 pneumonia have long‐term residual pulmonary disease. However, there is little documentation of the histopathological characteristics of lung sequelae post‐COVID‐19 and effective treatments. We present two Japanese cases of lung sequelae post‐COVID‐19. The patients were histopathologically diagnosed with organizing pneumonia (OP) or OP with fibrosis and no diffuse alveolar damage on video‐assisted thoracoscopic surgery. Case 1, who had been diagnosed with OP, was successfully treated with corticosteroid and other immunosuppressive agents over a 6‐month period. Although case 2, who had been diagnosed with OP with fibrosis, had a partial and unsatisfactory response to immunosuppressive agents, the patient responded to antifibrotic treatment including nintedanib. |
| first_indexed | 2024-12-17T20:38:22Z |
| format | Article |
| id | doaj.art-a82cc103c61a407fab5ad860ae1f39d7 |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-12-17T20:38:22Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-a82cc103c61a407fab5ad860ae1f39d72022-12-21T21:33:23ZengWileyRespirology Case Reports2051-33802021-12-01912n/an/a10.1002/rcr2.871Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgeryKeishi Sugino0Hirotaka Ono1Shuji Haraguchi2Seiji Igarashi3Akira Hebisawa4Eiyasu Tsuboi5Department of Respiratory Medicine Tsuboi Hospital Koriyama City JapanDepartment of Respiratory Medicine Tsuboi Hospital Koriyama City JapanDepartment of Chest Surgery Tsuboi Hospital Koriyama City JapanDepartment of Diagnostic Pathology Tsuboi Hospital Koriyama City JapanDepartment of Clinical Pathology Asahi Central Hospital Asahi JapanDepartment of Respiratory Medicine Tsuboi Hospital Koriyama City JapanAbstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Many survivors of serious COVID‐19 pneumonia have long‐term residual pulmonary disease. However, there is little documentation of the histopathological characteristics of lung sequelae post‐COVID‐19 and effective treatments. We present two Japanese cases of lung sequelae post‐COVID‐19. The patients were histopathologically diagnosed with organizing pneumonia (OP) or OP with fibrosis and no diffuse alveolar damage on video‐assisted thoracoscopic surgery. Case 1, who had been diagnosed with OP, was successfully treated with corticosteroid and other immunosuppressive agents over a 6‐month period. Although case 2, who had been diagnosed with OP with fibrosis, had a partial and unsatisfactory response to immunosuppressive agents, the patient responded to antifibrotic treatment including nintedanib.https://doi.org/10.1002/rcr2.871coronavirus disease 2019corticosteroidorganizing pneumoniasevere acute respiratory syndrome coronavirus 2video‐assisted thoracoscopic surgery |
| spellingShingle | Keishi Sugino Hirotaka Ono Shuji Haraguchi Seiji Igarashi Akira Hebisawa Eiyasu Tsuboi Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery Respirology Case Reports coronavirus disease 2019 corticosteroid organizing pneumonia severe acute respiratory syndrome coronavirus 2 video‐assisted thoracoscopic surgery |
| title | Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery |
| title_full | Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery |
| title_fullStr | Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery |
| title_full_unstemmed | Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery |
| title_short | Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery |
| title_sort | post coronavirus disease 2019 organizing pneumonia confirmed pathologically by video assisted thoracoscopic surgery |
| topic | coronavirus disease 2019 corticosteroid organizing pneumonia severe acute respiratory syndrome coronavirus 2 video‐assisted thoracoscopic surgery |
| url | https://doi.org/10.1002/rcr2.871 |
| work_keys_str_mv | AT keishisugino postcoronavirusdisease2019organizingpneumoniaconfirmedpathologicallybyvideoassistedthoracoscopicsurgery AT hirotakaono postcoronavirusdisease2019organizingpneumoniaconfirmedpathologicallybyvideoassistedthoracoscopicsurgery AT shujiharaguchi postcoronavirusdisease2019organizingpneumoniaconfirmedpathologicallybyvideoassistedthoracoscopicsurgery AT seijiigarashi postcoronavirusdisease2019organizingpneumoniaconfirmedpathologicallybyvideoassistedthoracoscopicsurgery AT akirahebisawa postcoronavirusdisease2019organizingpneumoniaconfirmedpathologicallybyvideoassistedthoracoscopicsurgery AT eiyasutsuboi postcoronavirusdisease2019organizingpneumoniaconfirmedpathologicallybyvideoassistedthoracoscopicsurgery |