Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects
George Kymionis,1 George Kontadakis,1,2 Michael Grentzelos,1 Myrsini Petrelli1 1Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland; 2Laboratory of Vision and Optics, University of Crete, Heraklion, GreeceCorrespondence:...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-06-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/long-term-follow-up-of-combined-photorefractive-keratectomy-and-cornea-peer-reviewed-fulltext-article-OPTH |
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| author | Kymionis G Kontadakis G Grentzelos M Petrelli M |
| author_facet | Kymionis G Kontadakis G Grentzelos M Petrelli M |
| author_sort | Kymionis G |
| collection | DOAJ |
| description | George Kymionis,1 George Kontadakis,1,2 Michael Grentzelos,1 Myrsini Petrelli1 1Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland; 2Laboratory of Vision and Optics, University of Crete, Heraklion, GreeceCorrespondence: George KontadakisLaboratory of Vision and Optics, University of Crete, Heraklion, GreeceEmail kontadas@yahoo.comPurpose: To present the long-term outcomes of photorefractive keratectomy (PRK) combined with accelerated corneal cross-linking (CXL) for refractive error correction in a series of keratoconus suspects.Setting: University practice.Design: Retrospective case series.Methods: A series of patients with topographic findings suspicious for keratoconus underwent simultaneous PRK and prophylactic accelerated CXL (5 minutes with intensity of 18 mW/cm2) for the correction of their refractive error. The results were recorded for more than 4 years postoperatively.Results: Ten eyes of 5 patients were included. Mean follow-up was 58.2 months (range from 54 to 62 months). Mean age at presentation was 25 years (range from 22 to 32 years). Mean spherical equivalent (SE) refraction was − 2.76 (standard deviation [SD] 0.97D, range from − 1.25 to − 4.00 diopters [D]), while mean central corneal thickness was 511μm (SD 13μm, range from 485 to 536 μm). At last, follow-up 9 out of 10 eyes had SE refraction within ± 0.50D and all eyes had SE within ± 1.00D. None of the eyes lost any line of corrected distance visual acuity (CDVA), whereas 1 eye gained one line of CDVA. All eyes demonstrated stability of their results during the follow-up period.Conclusion: Simultaneous PRK followed by prophylactic accelerated CXL (PRK plus) appeared to be a safe and effective option for the correction of the refractive error in this series of keratoconus suspect patients, without compromising corneal stability for up to 5 years postoperatively.Keywords: corneal crosslinking, photorefractive keratoplasty, forme fruste keratoconus, corneal topography, irregular astigmatism |
| first_indexed | 2024-12-20T21:26:18Z |
| format | Article |
| id | doaj.art-a830c44df4734b019968bae913d82e5a |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-20T21:26:18Z |
| publishDate | 2021-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-a830c44df4734b019968bae913d82e5a2022-12-21T19:26:09ZengDove Medical PressClinical Ophthalmology1177-54832021-06-01Volume 152403241065701Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus SuspectsKymionis GKontadakis GGrentzelos MPetrelli MGeorge Kymionis,1 George Kontadakis,1,2 Michael Grentzelos,1 Myrsini Petrelli1 1Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland; 2Laboratory of Vision and Optics, University of Crete, Heraklion, GreeceCorrespondence: George KontadakisLaboratory of Vision and Optics, University of Crete, Heraklion, GreeceEmail kontadas@yahoo.comPurpose: To present the long-term outcomes of photorefractive keratectomy (PRK) combined with accelerated corneal cross-linking (CXL) for refractive error correction in a series of keratoconus suspects.Setting: University practice.Design: Retrospective case series.Methods: A series of patients with topographic findings suspicious for keratoconus underwent simultaneous PRK and prophylactic accelerated CXL (5 minutes with intensity of 18 mW/cm2) for the correction of their refractive error. The results were recorded for more than 4 years postoperatively.Results: Ten eyes of 5 patients were included. Mean follow-up was 58.2 months (range from 54 to 62 months). Mean age at presentation was 25 years (range from 22 to 32 years). Mean spherical equivalent (SE) refraction was − 2.76 (standard deviation [SD] 0.97D, range from − 1.25 to − 4.00 diopters [D]), while mean central corneal thickness was 511μm (SD 13μm, range from 485 to 536 μm). At last, follow-up 9 out of 10 eyes had SE refraction within ± 0.50D and all eyes had SE within ± 1.00D. None of the eyes lost any line of corrected distance visual acuity (CDVA), whereas 1 eye gained one line of CDVA. All eyes demonstrated stability of their results during the follow-up period.Conclusion: Simultaneous PRK followed by prophylactic accelerated CXL (PRK plus) appeared to be a safe and effective option for the correction of the refractive error in this series of keratoconus suspect patients, without compromising corneal stability for up to 5 years postoperatively.Keywords: corneal crosslinking, photorefractive keratoplasty, forme fruste keratoconus, corneal topography, irregular astigmatismhttps://www.dovepress.com/long-term-follow-up-of-combined-photorefractive-keratectomy-and-cornea-peer-reviewed-fulltext-article-OPTHcorneal crosslinkingphotorefractive keratoplastyforme fruste keratoconuscorneal topographyirregular astigmatism |
| spellingShingle | Kymionis G Kontadakis G Grentzelos M Petrelli M Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects Clinical Ophthalmology corneal crosslinking photorefractive keratoplasty forme fruste keratoconus corneal topography irregular astigmatism |
| title | Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects |
| title_full | Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects |
| title_fullStr | Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects |
| title_full_unstemmed | Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects |
| title_short | Long-Term Follow-Up of Combined Photorefractive Keratectomy and Corneal Crosslinking in Keratoconus Suspects |
| title_sort | long term follow up of combined photorefractive keratectomy and corneal crosslinking in keratoconus suspects |
| topic | corneal crosslinking photorefractive keratoplasty forme fruste keratoconus corneal topography irregular astigmatism |
| url | https://www.dovepress.com/long-term-follow-up-of-combined-photorefractive-keratectomy-and-cornea-peer-reviewed-fulltext-article-OPTH |
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