Hiding in plain sight? A review of post-convulsive leukocyte elevations
During physiological stress responses such as vigorous exercise, emotional states of fear and rage, and asphyxia, the nervous system induces a massive release of systemic catecholamines that prepares the body for survival by increasing cardiac output and redirecting blood flow from non-essential org...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1021042/full |
| _version_ | 1811255745764655104 |
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| author | Jose L. Vega Jose L. Vega Barry R. Komisaruk Mark Stewart Mark Stewart |
| author_facet | Jose L. Vega Jose L. Vega Barry R. Komisaruk Mark Stewart Mark Stewart |
| author_sort | Jose L. Vega |
| collection | DOAJ |
| description | During physiological stress responses such as vigorous exercise, emotional states of fear and rage, and asphyxia, the nervous system induces a massive release of systemic catecholamines that prepares the body for survival by increasing cardiac output and redirecting blood flow from non-essential organs into the cardiopulmonary circulation. A curious byproduct of this vital response is a sudden, transient, and redistributive leukocytosis provoked mostly by the resultant shear forces exerted by rapid blood flow on marginated leukocytes. Generalized convulsive seizures, too, result in catecholamine surges accompanied by similar leukocytoses, the magnitude of which appears to be rooted in semiological factors such as convulsive duration and intensity. This manuscript reviews the history, kinetics, physiology, and clinical significance of post-convulsive leukocyte elevations and discusses their clinical utility, including a proposed role in the scientific investigation of sudden unexpected death in epilepsy (SUDEP). |
| first_indexed | 2024-04-12T17:29:22Z |
| format | Article |
| id | doaj.art-a831a6c4242941f18eb047f001cd3195 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T17:29:22Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-a831a6c4242941f18eb047f001cd31952022-12-22T03:23:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.10210421021042Hiding in plain sight? A review of post-convulsive leukocyte elevationsJose L. Vega0Jose L. Vega1Barry R. Komisaruk2Mark Stewart3Mark Stewart4Department of Psychology, Rutgers University-Newark, Newark, NJ, United StatesTeleNeurologia SAS, Medellin, ColombiaDepartment of Psychology, Rutgers University-Newark, Newark, NJ, United StatesDepartment of Neurology, State University of New York Health Sciences University, Brooklyn, NY, United StatesDepartment of Physiology and Pharmacology, State University of New York Health Sciences University, Brooklyn, NY, United StatesDuring physiological stress responses such as vigorous exercise, emotional states of fear and rage, and asphyxia, the nervous system induces a massive release of systemic catecholamines that prepares the body for survival by increasing cardiac output and redirecting blood flow from non-essential organs into the cardiopulmonary circulation. A curious byproduct of this vital response is a sudden, transient, and redistributive leukocytosis provoked mostly by the resultant shear forces exerted by rapid blood flow on marginated leukocytes. Generalized convulsive seizures, too, result in catecholamine surges accompanied by similar leukocytoses, the magnitude of which appears to be rooted in semiological factors such as convulsive duration and intensity. This manuscript reviews the history, kinetics, physiology, and clinical significance of post-convulsive leukocyte elevations and discusses their clinical utility, including a proposed role in the scientific investigation of sudden unexpected death in epilepsy (SUDEP).https://www.frontiersin.org/articles/10.3389/fneur.2022.1021042/fullleukocytosisleukocyte marginationseizureSUDEPneurogenic pulmonary edemacatecholamine |
| spellingShingle | Jose L. Vega Jose L. Vega Barry R. Komisaruk Mark Stewart Mark Stewart Hiding in plain sight? A review of post-convulsive leukocyte elevations Frontiers in Neurology leukocytosis leukocyte margination seizure SUDEP neurogenic pulmonary edema catecholamine |
| title | Hiding in plain sight? A review of post-convulsive leukocyte elevations |
| title_full | Hiding in plain sight? A review of post-convulsive leukocyte elevations |
| title_fullStr | Hiding in plain sight? A review of post-convulsive leukocyte elevations |
| title_full_unstemmed | Hiding in plain sight? A review of post-convulsive leukocyte elevations |
| title_short | Hiding in plain sight? A review of post-convulsive leukocyte elevations |
| title_sort | hiding in plain sight a review of post convulsive leukocyte elevations |
| topic | leukocytosis leukocyte margination seizure SUDEP neurogenic pulmonary edema catecholamine |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1021042/full |
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