Assessing the Percent of Necrosis after Neoadjuvant Chemotherapy with 24hr Infusional Cisplatin/3 Days Doxorubicin Intermittent with IfosfamideDoxorubicin for Osteosarcoma
Introduction: Osteosarcoma is the most common primary bone tumor in children and young adults and appropriate chemotherapy can increase limb sparing and overall survival. Yet, the toxicity of chemotherapy regimens including MTX can be life threatening. Therefore; we tried another chemotherapy regime...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2014-03-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/434 |
| _version_ | 1827844455206486016 |
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| author | Mozhgan Aalam Samimi Nooshin Mirkheshti Abdolreza Pazouki |
| author_facet | Mozhgan Aalam Samimi Nooshin Mirkheshti Abdolreza Pazouki |
| author_sort | Mozhgan Aalam Samimi |
| collection | DOAJ |
| description | Introduction: Osteosarcoma is the most common primary bone tumor in children and young adults and appropriate chemotherapy can increase limb sparing and overall survival. Yet, the toxicity of chemotherapy regimens including MTX can be life threatening. Therefore; we tried another chemotherapy regimen for these patients.
Method and materials: We investigated 15 patients aged 15 to 40 years old and used continuous infusion of cisplatin, doxorubicin intermittently with ifosfamide, doxorubicin as neoadjuvant chemotherapy. Percent of necrosis and toxicities was recorded for each patient.
Results: Out of 15 patients investigated, 13 were males and 2 females. Tumor necrosis≥ 90% (defined as good necrosis) was observed in 60% of patients. 26.7% of the patients showed leucopenia grade three or four, 26.7% had anemia grade three or four, and 20% showed thrombocytopenia grade three or four.
Conclusion: The above chemotherapy regimen can cause as good necrosis as the chemotherapy regimens including high dose of MTX with reduced toxicity and less nursing cares and laboratory tests. Of course small sample size limits extension of our result to all patients but trying this regimen is recommended in more patients to see more reliable results. |
| first_indexed | 2024-03-12T08:42:08Z |
| format | Article |
| id | doaj.art-a832aff7d3b146d596a3405f50b3459e |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T08:42:08Z |
| publishDate | 2014-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-a832aff7d3b146d596a3405f50b3459e2023-09-02T16:41:32ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072014-03-0181420Assessing the Percent of Necrosis after Neoadjuvant Chemotherapy with 24hr Infusional Cisplatin/3 Days Doxorubicin Intermittent with IfosfamideDoxorubicin for OsteosarcomaMozhgan Aalam Samimi0Nooshin Mirkheshti1Abdolreza Pazouki2Assistant Professor, Minimally Invasive Surgery Research Center, Iran University Of Medical Science, Tehran, Iran.Medical Doctor, East Sage Research Corporation, Isfahan Science and Technology Town, Isfahan, Iran.Assistant Professor, Minimally Invasive Surgery Research Center, Iran University Of Medical Science, Tehran, Iran.Introduction: Osteosarcoma is the most common primary bone tumor in children and young adults and appropriate chemotherapy can increase limb sparing and overall survival. Yet, the toxicity of chemotherapy regimens including MTX can be life threatening. Therefore; we tried another chemotherapy regimen for these patients. Method and materials: We investigated 15 patients aged 15 to 40 years old and used continuous infusion of cisplatin, doxorubicin intermittently with ifosfamide, doxorubicin as neoadjuvant chemotherapy. Percent of necrosis and toxicities was recorded for each patient. Results: Out of 15 patients investigated, 13 were males and 2 females. Tumor necrosis≥ 90% (defined as good necrosis) was observed in 60% of patients. 26.7% of the patients showed leucopenia grade three or four, 26.7% had anemia grade three or four, and 20% showed thrombocytopenia grade three or four. Conclusion: The above chemotherapy regimen can cause as good necrosis as the chemotherapy regimens including high dose of MTX with reduced toxicity and less nursing cares and laboratory tests. Of course small sample size limits extension of our result to all patients but trying this regimen is recommended in more patients to see more reliable results.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/434NecrosisNeoadjuvant chemotherapyOsteosarcoma |
| spellingShingle | Mozhgan Aalam Samimi Nooshin Mirkheshti Abdolreza Pazouki Assessing the Percent of Necrosis after Neoadjuvant Chemotherapy with 24hr Infusional Cisplatin/3 Days Doxorubicin Intermittent with IfosfamideDoxorubicin for Osteosarcoma International Journal of Hematology-Oncology and Stem Cell Research Necrosis Neoadjuvant chemotherapy Osteosarcoma |
| title | Assessing the Percent of Necrosis after Neoadjuvant Chemotherapy with 24hr Infusional Cisplatin/3 Days Doxorubicin Intermittent with IfosfamideDoxorubicin for Osteosarcoma |
| title_full | Assessing the Percent of Necrosis after Neoadjuvant Chemotherapy with 24hr Infusional Cisplatin/3 Days Doxorubicin Intermittent with IfosfamideDoxorubicin for Osteosarcoma |
| title_fullStr | Assessing the Percent of Necrosis after Neoadjuvant Chemotherapy with 24hr Infusional Cisplatin/3 Days Doxorubicin Intermittent with IfosfamideDoxorubicin for Osteosarcoma |
| title_full_unstemmed | Assessing the Percent of Necrosis after Neoadjuvant Chemotherapy with 24hr Infusional Cisplatin/3 Days Doxorubicin Intermittent with IfosfamideDoxorubicin for Osteosarcoma |
| title_short | Assessing the Percent of Necrosis after Neoadjuvant Chemotherapy with 24hr Infusional Cisplatin/3 Days Doxorubicin Intermittent with IfosfamideDoxorubicin for Osteosarcoma |
| title_sort | assessing the percent of necrosis after neoadjuvant chemotherapy with 24hr infusional cisplatin 3 days doxorubicin intermittent with ifosfamidedoxorubicin for osteosarcoma |
| topic | Necrosis Neoadjuvant chemotherapy Osteosarcoma |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/434 |
| work_keys_str_mv | AT mozhganaalamsamimi assessingthepercentofnecrosisafterneoadjuvantchemotherapywith24hrinfusionalcisplatin3daysdoxorubicinintermittentwithifosfamidedoxorubicinforosteosarcoma AT nooshinmirkheshti assessingthepercentofnecrosisafterneoadjuvantchemotherapywith24hrinfusionalcisplatin3daysdoxorubicinintermittentwithifosfamidedoxorubicinforosteosarcoma AT abdolrezapazouki assessingthepercentofnecrosisafterneoadjuvantchemotherapywith24hrinfusionalcisplatin3daysdoxorubicinintermittentwithifosfamidedoxorubicinforosteosarcoma |