Clobazam as an Add-on Therapy of Patients with Drug-resistant Epilepsy: Experience of a Tertiary Epilepsy Center
Objectives:This retrospective study aimed to overview the efficacy and side effects of clobazam in patients with drug-resistant epilepsy who were followed in a tertiary epilepsy center.Methods:The patients who had been started clobazam as add-on therapy and have been followed for at least one year w...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2020-12-01
|
| Series: | Archives of Epilepsy |
| Subjects: | |
| Online Access: |
http://archepilepsy.org/archives/archive-detail/article-preview/clobazam-as-an-add-on-therapy-of-patients-with-dru/54683
|
| _version_ | 1827888831330779136 |
|---|---|
| author | Nermin Görkem ŞİRİN Betül BAYKAN Nerses BEBEK |
| author_facet | Nermin Görkem ŞİRİN Betül BAYKAN Nerses BEBEK |
| author_sort | Nermin Görkem ŞİRİN |
| collection | DOAJ |
| description | Objectives:This retrospective study aimed to overview the efficacy and side effects of clobazam in patients with drug-resistant epilepsy who were followed in a tertiary epilepsy center.Methods:The patients who had been started clobazam as add-on therapy and have been followed for at least one year were recruited to participate in this study. The clinical, electrophysiologic and imaging features of the patients were reviewed. The side effects and efficacy of clobazam were noted.Results:Twelve patients with drug-resistant epilepsy who had focal epilepsy with structural etiology in nine, focal epilepsy with unknown etiology in one, combined focal and generalized epilepsy in one and epilepsy with myoclonic absences in one were included in this study. All patients had at least two antiepileptic drugs with moderate to high doses before clobazam therapy. The side effects were sedation, irritability and blurred vision in three patients. Two patients became seizure-free and seven patients had improved remarkably (≥50% seizure reduction). Only one patient discontinued the drug because of the side effects.Conclusion:Our results provide evidence in the efficacy of clobazam as add-on therapy in patients with drug-resistant epilepsy. |
| first_indexed | 2024-03-12T20:39:24Z |
| format | Article |
| id | doaj.art-a8332a17d8744b5991cfc5085cfd408b |
| institution | Directory Open Access Journal |
| issn | 2792-0550 |
| language | English |
| last_indexed | 2024-03-12T20:39:24Z |
| publishDate | 2020-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Archives of Epilepsy |
| spelling | doaj.art-a8332a17d8744b5991cfc5085cfd408b2023-08-01T11:12:54ZengGalenos YayineviArchives of Epilepsy2792-05502020-12-0126315516010.14744/epilepsi.2020.9124913049054Clobazam as an Add-on Therapy of Patients with Drug-resistant Epilepsy: Experience of a Tertiary Epilepsy CenterNermin Görkem ŞİRİN0Betül BAYKAN1Nerses BEBEK2 Department of Neurology, Istanbul University İstanbul Faculty of Medicine, İstanbul, Turkey Department of Neurology, Istanbul University İstanbul Faculty of Medicine, İstanbul, Turkey Department of Neurology, Istanbul University İstanbul Faculty of Medicine, İstanbul, Turkey Objectives:This retrospective study aimed to overview the efficacy and side effects of clobazam in patients with drug-resistant epilepsy who were followed in a tertiary epilepsy center.Methods:The patients who had been started clobazam as add-on therapy and have been followed for at least one year were recruited to participate in this study. The clinical, electrophysiologic and imaging features of the patients were reviewed. The side effects and efficacy of clobazam were noted.Results:Twelve patients with drug-resistant epilepsy who had focal epilepsy with structural etiology in nine, focal epilepsy with unknown etiology in one, combined focal and generalized epilepsy in one and epilepsy with myoclonic absences in one were included in this study. All patients had at least two antiepileptic drugs with moderate to high doses before clobazam therapy. The side effects were sedation, irritability and blurred vision in three patients. Two patients became seizure-free and seven patients had improved remarkably (≥50% seizure reduction). Only one patient discontinued the drug because of the side effects.Conclusion:Our results provide evidence in the efficacy of clobazam as add-on therapy in patients with drug-resistant epilepsy. http://archepilepsy.org/archives/archive-detail/article-preview/clobazam-as-an-add-on-therapy-of-patients-with-dru/54683 antiepileptic drugclobazamdrug-resistant epilepsymedically refractory |
| spellingShingle | Nermin Görkem ŞİRİN Betül BAYKAN Nerses BEBEK Clobazam as an Add-on Therapy of Patients with Drug-resistant Epilepsy: Experience of a Tertiary Epilepsy Center Archives of Epilepsy antiepileptic drug clobazam drug-resistant epilepsy medically refractory |
| title | Clobazam as an Add-on Therapy of Patients with Drug-resistant Epilepsy: Experience of a Tertiary Epilepsy Center |
| title_full | Clobazam as an Add-on Therapy of Patients with Drug-resistant Epilepsy: Experience of a Tertiary Epilepsy Center |
| title_fullStr | Clobazam as an Add-on Therapy of Patients with Drug-resistant Epilepsy: Experience of a Tertiary Epilepsy Center |
| title_full_unstemmed | Clobazam as an Add-on Therapy of Patients with Drug-resistant Epilepsy: Experience of a Tertiary Epilepsy Center |
| title_short | Clobazam as an Add-on Therapy of Patients with Drug-resistant Epilepsy: Experience of a Tertiary Epilepsy Center |
| title_sort | clobazam as an add on therapy of patients with drug resistant epilepsy experience of a tertiary epilepsy center |
| topic | antiepileptic drug clobazam drug-resistant epilepsy medically refractory |
| url |
http://archepilepsy.org/archives/archive-detail/article-preview/clobazam-as-an-add-on-therapy-of-patients-with-dru/54683
|
| work_keys_str_mv | AT nermingorkemsirin clobazamasanaddontherapyofpatientswithdrugresistantepilepsyexperienceofatertiaryepilepsycenter AT betulbaykan clobazamasanaddontherapyofpatientswithdrugresistantepilepsyexperienceofatertiaryepilepsycenter AT nersesbebek clobazamasanaddontherapyofpatientswithdrugresistantepilepsyexperienceofatertiaryepilepsycenter |