Choline-deficiency fatty liver: impaired release of hepatic triglycerides
After intravenous injection of palmitate-1-14C to rats fed a choline-deficient (CD) or choline-supplemented (CS) diet for 15-18 hr, liver triglycerides became labeled very rapidly. In CS, but not in CD rats, there was a considerable loss, with time, of radioactivity from liver triglycerides. At the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1968-07-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752042721X |
| _version_ | 1818672926448156672 |
|---|---|
| author | B. Lombardi P. Pani F.F. Schlunk |
| author_facet | B. Lombardi P. Pani F.F. Schlunk |
| author_sort | B. Lombardi |
| collection | DOAJ |
| description | After intravenous injection of palmitate-1-14C to rats fed a choline-deficient (CD) or choline-supplemented (CS) diet for 15-18 hr, liver triglycerides became labeled very rapidly. In CS, but not in CD rats, there was a considerable loss, with time, of radioactivity from liver triglycerides. At the same time, significantly less radioactivity appeared in plasma triglycerides of CD rats than of CS animals. No difference was seen in the triglyceride content of microsomes isolated from the liver of rats fed the two diets. The lower radioactivity in plasma triglycerides of CD rats was essentially due to a lower level and specific activity of very low density lipoprotein triglycerides.After intravenous injection of Triton and labeled palmitate, considerably less radioactivity accumulated in plasma triglycerides and phospholipids of CD rats than of CS animals. Post-Triton hyperphospholipidemia was also less pronounced in CD rats.It was concluded that the fatty liver observed in CD rats results from an impaired release of hepatic triglycerides into plasma. |
| first_indexed | 2024-12-17T07:47:39Z |
| format | Article |
| id | doaj.art-a83353d7b04b48c8bfcc7d7461bfc628 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T07:47:39Z |
| publishDate | 1968-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-a83353d7b04b48c8bfcc7d7461bfc6282022-12-21T21:57:57ZengElsevierJournal of Lipid Research0022-22751968-07-0194437446Choline-deficiency fatty liver: impaired release of hepatic triglyceridesB. Lombardi0P. Pani1F.F. Schlunk2Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213After intravenous injection of palmitate-1-14C to rats fed a choline-deficient (CD) or choline-supplemented (CS) diet for 15-18 hr, liver triglycerides became labeled very rapidly. In CS, but not in CD rats, there was a considerable loss, with time, of radioactivity from liver triglycerides. At the same time, significantly less radioactivity appeared in plasma triglycerides of CD rats than of CS animals. No difference was seen in the triglyceride content of microsomes isolated from the liver of rats fed the two diets. The lower radioactivity in plasma triglycerides of CD rats was essentially due to a lower level and specific activity of very low density lipoprotein triglycerides.After intravenous injection of Triton and labeled palmitate, considerably less radioactivity accumulated in plasma triglycerides and phospholipids of CD rats than of CS animals. Post-Triton hyperphospholipidemia was also less pronounced in CD rats.It was concluded that the fatty liver observed in CD rats results from an impaired release of hepatic triglycerides into plasma.http://www.sciencedirect.com/science/article/pii/S002222752042721Xcholine deficiencyratpathogenesisfatty livertriglyceridesphospholipids |
| spellingShingle | B. Lombardi P. Pani F.F. Schlunk Choline-deficiency fatty liver: impaired release of hepatic triglycerides Journal of Lipid Research choline deficiency rat pathogenesis fatty liver triglycerides phospholipids |
| title | Choline-deficiency fatty liver: impaired release of hepatic triglycerides |
| title_full | Choline-deficiency fatty liver: impaired release of hepatic triglycerides |
| title_fullStr | Choline-deficiency fatty liver: impaired release of hepatic triglycerides |
| title_full_unstemmed | Choline-deficiency fatty liver: impaired release of hepatic triglycerides |
| title_short | Choline-deficiency fatty liver: impaired release of hepatic triglycerides |
| title_sort | choline deficiency fatty liver impaired release of hepatic triglycerides |
| topic | choline deficiency rat pathogenesis fatty liver triglycerides phospholipids |
| url | http://www.sciencedirect.com/science/article/pii/S002222752042721X |
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