Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in Sweden
Abstract Smoking has been linked with both increased and decreased risk of COVID-19, prompting the hypothesis of a protective role of nicotine in the pathogenesis of the disease. Studies of the association between use of smokeless tobacco and COVID-19 would help refining this hypothesis. We analysed...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28091-4 |
| _version_ | 1797945967371091968 |
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| author | M. R. Galanti F. Andersson I. H. Caspersen S. Peña S. Karvonen P. Magnus E. Raffetti N. Orsini C. Magnusson A. N. Shaaban M. P. Hergens P. Skott |
| author_facet | M. R. Galanti F. Andersson I. H. Caspersen S. Peña S. Karvonen P. Magnus E. Raffetti N. Orsini C. Magnusson A. N. Shaaban M. P. Hergens P. Skott |
| author_sort | M. R. Galanti |
| collection | DOAJ |
| description | Abstract Smoking has been linked with both increased and decreased risk of COVID-19, prompting the hypothesis of a protective role of nicotine in the pathogenesis of the disease. Studies of the association between use of smokeless tobacco and COVID-19 would help refining this hypothesis. We analysed data from 424,386 residents in the Stockholm Region, Sweden, with information on smoking and smokeless tobacco (snus) use prior to the pandemic obtained from dental records. Diagnoses of COVID-19 between February and October 2020 were obtained from health-care registers. We estimated the risk of receiving a diagnosis of COVID-19 for current smokers and for current snus users relative to non-users of tobacco, adjusting for potential confounders (aRR). The aRR of COVID -19 was elevated for current snus users (1.09 ;95%CI = 0.99–1.21 among men and 1.15; 95%CI = 1.00–1.33 among women). The risk for women consuming more than 1 can/day was twice as high as among non-users of tobacco. Current smoking was negatively associated with risk of COVID-19 (aRR = 0.68; 95% CI = 0.61–0.75); including hospital admission (aRR = 0.60; 95% CI = 0.47–0.76) and intensive care (aRR = 0.43; 95% CI = 0.21–0.89). The hypothesis of a protective effect of tobacco nicotine on COVID-19 was not supported by the findings. The negative association between smoking and COVID-19 remains unexplained. |
| first_indexed | 2024-04-10T21:03:25Z |
| format | Article |
| id | doaj.art-a834928f99cd41deb5d82f0a3fa19975 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T21:03:25Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a834928f99cd41deb5d82f0a3fa199752023-01-22T12:09:38ZengNature PortfolioScientific Reports2045-23222023-01-011311910.1038/s41598-023-28091-4Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in SwedenM. R. Galanti0F. Andersson1I. H. Caspersen2S. Peña3S. Karvonen4P. Magnus5E. Raffetti6N. Orsini7C. Magnusson8A. N. Shaaban9M. P. Hergens10P. Skott11Department of Global Public Health, Karolinska InstitutetDepartment of Global Public Health, Karolinska InstitutetCentre for Fertility and Health, Norwegian Institute of Public HealthFinnish Institute for Health and WelfareFinnish Institute for Health and WelfareCentre for Fertility and Health, Norwegian Institute of Public HealthDepartment of Global Public Health, Karolinska InstitutetDepartment of Global Public Health, Karolinska InstitutetDepartment of Global Public Health, Karolinska InstitutetDepartment of Global Public Health, Karolinska InstitutetUnit for Communicable Disease ControlDepartment of Orofacial Medicine, Folktandvården StockholmAbstract Smoking has been linked with both increased and decreased risk of COVID-19, prompting the hypothesis of a protective role of nicotine in the pathogenesis of the disease. Studies of the association between use of smokeless tobacco and COVID-19 would help refining this hypothesis. We analysed data from 424,386 residents in the Stockholm Region, Sweden, with information on smoking and smokeless tobacco (snus) use prior to the pandemic obtained from dental records. Diagnoses of COVID-19 between February and October 2020 were obtained from health-care registers. We estimated the risk of receiving a diagnosis of COVID-19 for current smokers and for current snus users relative to non-users of tobacco, adjusting for potential confounders (aRR). The aRR of COVID -19 was elevated for current snus users (1.09 ;95%CI = 0.99–1.21 among men and 1.15; 95%CI = 1.00–1.33 among women). The risk for women consuming more than 1 can/day was twice as high as among non-users of tobacco. Current smoking was negatively associated with risk of COVID-19 (aRR = 0.68; 95% CI = 0.61–0.75); including hospital admission (aRR = 0.60; 95% CI = 0.47–0.76) and intensive care (aRR = 0.43; 95% CI = 0.21–0.89). The hypothesis of a protective effect of tobacco nicotine on COVID-19 was not supported by the findings. The negative association between smoking and COVID-19 remains unexplained.https://doi.org/10.1038/s41598-023-28091-4 |
| spellingShingle | M. R. Galanti F. Andersson I. H. Caspersen S. Peña S. Karvonen P. Magnus E. Raffetti N. Orsini C. Magnusson A. N. Shaaban M. P. Hergens P. Skott Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in Sweden Scientific Reports |
| title | Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in Sweden |
| title_full | Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in Sweden |
| title_fullStr | Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in Sweden |
| title_full_unstemmed | Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in Sweden |
| title_short | Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in Sweden |
| title_sort | current tobacco use and covid 19 diagnoses in a cohort of adult clients of public dental clinics in sweden |
| url | https://doi.org/10.1038/s41598-023-28091-4 |
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