Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial Infarction
Background : The aim of this study was to investigate the predictive value of estimated glomerular filtration rate (eGFR) calculated with the simplified Modification of Diet in Renal Disease (MDRD) Study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations for prognosis in elder...
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| Format: | Article |
| Language: | English |
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Korea Geriatrics Society
2017-03-01
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| Series: | Annals of Geriatric Medicine and Research |
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| Online Access: | http://www.e-agmr.org/journal/view.html?doi=10.4235/agmr.2017.21.1.10 |
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| author | Namkyun Kim Hun Sik Park Jae Yong Yoon Hyun Jun Cho Chang-Yeon Kim Jae-Hyung Roh Myung Hwan Bae Jang Hoon Lee Dong Heon Yang Yongkeun Cho Shung Chull Chae Jihyun Sohn Se Yong Jang |
| author_facet | Namkyun Kim Hun Sik Park Jae Yong Yoon Hyun Jun Cho Chang-Yeon Kim Jae-Hyung Roh Myung Hwan Bae Jang Hoon Lee Dong Heon Yang Yongkeun Cho Shung Chull Chae Jihyun Sohn Se Yong Jang |
| author_sort | Namkyun Kim |
| collection | DOAJ |
| description | Background : The aim of this study was to investigate the predictive value of estimated glomerular filtration rate (eGFR) calculated with the simplified Modification of Diet in Renal Disease (MDRD) Study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations for prognosis in elderly patients with acute myocardial infarction (AMI). Methods : This study included 1,372 patients (mean age, 64.2±11.8 years; men, 67.9%) entered in the Kyungpook National University Hospital Acute Myocardial Infarction Registry from November 2005 to February 2010. We analyzed 1-year major adverse cardiac events (MACE) according to the eGFR calculated with the simplified MDRD Study and CKD-EPI equations. Results : The mean eGFR values calculated with the MDRD Study and CKD-EPI equations were 81.3±44.4 and 78.5±27.1 mL/(min/1.73 m²), respectively. In receiver operating characteristic curve analysis for prediction of 1-year MACE, the area under the curve based on the CKD-EPI equation was greater than that using the MDRD Study equation (CKD-EPI equation vs. MDRD Study equation: 0.691 vs. 0.674, p=0.041). Multivariate analysis using a Cox proportional hazards model revealed that the eGFR calculated with the CKD-EPI equation was an independent predictor of the occurrence of MACE within 1 year after AMI. However, eGFR calculated with the MDRD Study equation did not have predictive value. Furthermore, the eGFR calculated with the CKD-EPI equation had incremental prognostic value for established risk factors (chi-square=5.78, p=0.016). Conclusion : The eGFR calculated using the CKD-EPI equation was an independent predictor of 1-year MACE in elderly patients with AMI. |
| first_indexed | 2024-12-21T18:27:45Z |
| format | Article |
| id | doaj.art-a83571ff2b2e4c05b53d23564f8701b0 |
| institution | Directory Open Access Journal |
| issn | 2508-4798 |
| language | English |
| last_indexed | 2024-12-21T18:27:45Z |
| publishDate | 2017-03-01 |
| publisher | Korea Geriatrics Society |
| record_format | Article |
| series | Annals of Geriatric Medicine and Research |
| spelling | doaj.art-a83571ff2b2e4c05b53d23564f8701b02022-12-21T18:54:22ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982017-03-01211101610.4235/agmr.2017.21.1.10agmr.2017.21.1.10Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial InfarctionNamkyun Kim0Hun Sik Park1Jae Yong Yoon2Hyun Jun Cho3Chang-Yeon Kim4Jae-Hyung Roh5Myung Hwan Bae6Jang Hoon Lee7Dong Heon Yang8Yongkeun Cho9Shung Chull Chae10Jihyun Sohn11Se Yong Jang12Department of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaCardioloy Center, Kyungpook National University Hospital, Daegu, KoreaCardioloy Center, Kyungpook National University Hospital, Daegu, KoreaBackground : The aim of this study was to investigate the predictive value of estimated glomerular filtration rate (eGFR) calculated with the simplified Modification of Diet in Renal Disease (MDRD) Study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations for prognosis in elderly patients with acute myocardial infarction (AMI). Methods : This study included 1,372 patients (mean age, 64.2±11.8 years; men, 67.9%) entered in the Kyungpook National University Hospital Acute Myocardial Infarction Registry from November 2005 to February 2010. We analyzed 1-year major adverse cardiac events (MACE) according to the eGFR calculated with the simplified MDRD Study and CKD-EPI equations. Results : The mean eGFR values calculated with the MDRD Study and CKD-EPI equations were 81.3±44.4 and 78.5±27.1 mL/(min/1.73 m²), respectively. In receiver operating characteristic curve analysis for prediction of 1-year MACE, the area under the curve based on the CKD-EPI equation was greater than that using the MDRD Study equation (CKD-EPI equation vs. MDRD Study equation: 0.691 vs. 0.674, p=0.041). Multivariate analysis using a Cox proportional hazards model revealed that the eGFR calculated with the CKD-EPI equation was an independent predictor of the occurrence of MACE within 1 year after AMI. However, eGFR calculated with the MDRD Study equation did not have predictive value. Furthermore, the eGFR calculated with the CKD-EPI equation had incremental prognostic value for established risk factors (chi-square=5.78, p=0.016). Conclusion : The eGFR calculated using the CKD-EPI equation was an independent predictor of 1-year MACE in elderly patients with AMI.http://www.e-agmr.org/journal/view.html?doi=10.4235/agmr.2017.21.1.10Myocardial infarctionGlomerular filtration rateMajor adverse cardiac event |
| spellingShingle | Namkyun Kim Hun Sik Park Jae Yong Yoon Hyun Jun Cho Chang-Yeon Kim Jae-Hyung Roh Myung Hwan Bae Jang Hoon Lee Dong Heon Yang Yongkeun Cho Shung Chull Chae Jihyun Sohn Se Yong Jang Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial Infarction Annals of Geriatric Medicine and Research Myocardial infarction Glomerular filtration rate Major adverse cardiac event |
| title | Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial Infarction |
| title_full | Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial Infarction |
| title_fullStr | Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial Infarction |
| title_full_unstemmed | Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial Infarction |
| title_short | Predictive Value of Estimated Glomerular Filtration Rate for the Prognosis of Elderly Patients With Acute Myocardial Infarction |
| title_sort | predictive value of estimated glomerular filtration rate for the prognosis of elderly patients with acute myocardial infarction |
| topic | Myocardial infarction Glomerular filtration rate Major adverse cardiac event |
| url | http://www.e-agmr.org/journal/view.html?doi=10.4235/agmr.2017.21.1.10 |
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