Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest in capsaicin, resulting in increased scientific publications in recent years. Therefore,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.908487/full |
| _version_ | 1818532116298727424 |
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| author | Tomi Lois Adetunji Femi Olawale Chijioke Olisah Ademola Emmanuel Adetunji Adeyemi Oladapo Aremu Adeyemi Oladapo Aremu |
| author_facet | Tomi Lois Adetunji Femi Olawale Chijioke Olisah Ademola Emmanuel Adetunji Adeyemi Oladapo Aremu Adeyemi Oladapo Aremu |
| author_sort | Tomi Lois Adetunji |
| collection | DOAJ |
| description | Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest in capsaicin, resulting in increased scientific publications in recent years. Therefore, an in-depth bibliometric analysis of published literature on capsaicin from 2001 to 2021 was performed to assess the global research status, thematic and emerging areas, and potential insights into future research. Furthermore, recent research advances of capsaicin and its combination therapy on human cancer as well as their potential mechanisms of action were described. In the last two decades, research outputs on capsaicin have increased by an estimated 18% per year and were dominated by research articles at 93% of the 3753 assessed literature. In addition, anti-cancer/pharmacokinetics, cytotoxicity, in vivo neurological and pain research studies were the keyword clusters generated and designated as thematic domains for capsaicin research. It was evident that the United States, China, and Japan accounted for about 42% of 3753 publications that met the inclusion criteria. Also, visibly dominant collaboration nodes and networks with most of the other identified countries were established. Assessment of the eligible literature revealed that the potential of capsaicin for mitigating cancer mainly entailed its chemo-preventive effects, which were often linked to its ability to exert multi-biological effects such as anti-mutagenic, antioxidant and anti-inflammatory activities. However, clinical studies were limited, which may be related to some of the inherent challenges associated with capsaicin in the limited clinical trials. This review presents a novel approach to visualizing information about capsaicin research and a comprehensive perspective on the therapeutic significance and applications of capsaicin in the treatment of human cancer. |
| first_indexed | 2024-12-11T17:41:19Z |
| format | Article |
| id | doaj.art-a8379b1ef42b4f3091a03849320feeac |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T17:41:19Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a8379b1ef42b4f3091a03849320feeac2022-12-22T00:56:31ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.908487908487Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human CancerTomi Lois Adetunji0Femi Olawale1Chijioke Olisah2Ademola Emmanuel Adetunji3Adeyemi Oladapo Aremu4Adeyemi Oladapo Aremu5Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South AfricaNano-Gene and Drug Delivery Group, Discipline of Biochemistry, School of Life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Durban, South AfricaDepartment of Botany and Institute for Coastal and Marine Research, Nelson Mandela University, Port Elizabeth, South AfricaDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South AfricaIndigenous Knowledge Systems Centre, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, South AfricaSchool of Life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Durban, South AfricaCapsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest in capsaicin, resulting in increased scientific publications in recent years. Therefore, an in-depth bibliometric analysis of published literature on capsaicin from 2001 to 2021 was performed to assess the global research status, thematic and emerging areas, and potential insights into future research. Furthermore, recent research advances of capsaicin and its combination therapy on human cancer as well as their potential mechanisms of action were described. In the last two decades, research outputs on capsaicin have increased by an estimated 18% per year and were dominated by research articles at 93% of the 3753 assessed literature. In addition, anti-cancer/pharmacokinetics, cytotoxicity, in vivo neurological and pain research studies were the keyword clusters generated and designated as thematic domains for capsaicin research. It was evident that the United States, China, and Japan accounted for about 42% of 3753 publications that met the inclusion criteria. Also, visibly dominant collaboration nodes and networks with most of the other identified countries were established. Assessment of the eligible literature revealed that the potential of capsaicin for mitigating cancer mainly entailed its chemo-preventive effects, which were often linked to its ability to exert multi-biological effects such as anti-mutagenic, antioxidant and anti-inflammatory activities. However, clinical studies were limited, which may be related to some of the inherent challenges associated with capsaicin in the limited clinical trials. This review presents a novel approach to visualizing information about capsaicin research and a comprehensive perspective on the therapeutic significance and applications of capsaicin in the treatment of human cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.908487/fullanticancerbibliometricscytotoxicityTRPV 1vanilloid |
| spellingShingle | Tomi Lois Adetunji Femi Olawale Chijioke Olisah Ademola Emmanuel Adetunji Adeyemi Oladapo Aremu Adeyemi Oladapo Aremu Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer Frontiers in Oncology anticancer bibliometrics cytotoxicity TRPV 1 vanilloid |
| title | Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer |
| title_full | Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer |
| title_fullStr | Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer |
| title_full_unstemmed | Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer |
| title_short | Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer |
| title_sort | capsaicin a two decade systematic review of global research output and recent advances against human cancer |
| topic | anticancer bibliometrics cytotoxicity TRPV 1 vanilloid |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.908487/full |
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