CD161 Expression on Mucosa-Associated Invariant T Cells is Reduced in HIV-Infected Subjects Undergoing Antiretroviral Therapy Who Do Not Recover CD4+ T Cells

CD161 Expression on Mucosa-Associated Invariant T Cells is Reduced in HIV-Infected Subjects Undergoing Antiretroviral Therapy Who Do Not Recover CD4+ T Cells

Background: Mucosa-associated invariant T (MAIT) cells are a recently identified class of innate-like T cells that are involved in the mucosal immune response. MAIT cells are characterized by expression of TCR Va7.2 and CD161. In HIV infection, there is a profound early loss of MAIT cells from the c...

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Bibliographic Details
Main Authors: Michael L Freeman, Stephen R. Morris, Michael M. Lederman
Format: Article
Language:English
Published: Case Western Reserve University 2017-08-01
Series:Pathogens and Immunity
Subjects:
HIV
Immune Failure
MAIT cells
Online Access:http://paijournal.com/index.php/paijournal/article/view/136

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