Effect of herbal decoctions used in Mexican traditional medicine attenuate the adverse effects of a hypercaloric diet.
Background: In Mexico, plants as Ibervillea sonorae, Justicia spicigera, Mentha spicata, or Hibiscus sabdariffa are used to prepare decoctions that are traditionally used by the population to prevent or treat several diseases such as obesity and diabetes; scientific evidence is still in process. Pur...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031321001950 |
| _version_ | 1818869987682549760 |
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| author | Ana K. Castellanos-Jiménez Rosalía Reynoso-Camacho Nuria E. Rocha-Guzmán María A. Corella-Madueño Erika A. de los Ríos Luis M. Salgado |
| author_facet | Ana K. Castellanos-Jiménez Rosalía Reynoso-Camacho Nuria E. Rocha-Guzmán María A. Corella-Madueño Erika A. de los Ríos Luis M. Salgado |
| author_sort | Ana K. Castellanos-Jiménez |
| collection | DOAJ |
| description | Background: In Mexico, plants as Ibervillea sonorae, Justicia spicigera, Mentha spicata, or Hibiscus sabdariffa are used to prepare decoctions that are traditionally used by the population to prevent or treat several diseases such as obesity and diabetes; scientific evidence is still in process. Purpose: This study evaluated the therapeutic effects of traditional preparations (aqueous decoctions) of four herbs on obesity and its complications, such as insulin resistance, hypertriglyceridemia, and hepatic steatosis induced by a hypercaloric diet. Materials and methods: UPLC-PDA-ESI-QqQ analysis was performed to identify and quantify extractable phenolic constituents of each decoction. Metabolic alterations were induced by high fat and fructose diet in Wistar rats; decoctions were administered for 12 weeks. The effects of herbs on insulin resistant animals, glucose tolerance, insulin resistance, hypertriglyceridemia, and lipid storage in the liver and adipose tissue were assessed by biochemical assays and histological examination. Results: Rats treated with H. sabdariffa preventing body weight gain, improving glucose homeostasis, and decreasing adipocyte size. Meanwhile, the triglycerides and glucose levels in obese rats decreased after I. sonorae treatment. All decoctions showed no adverse effects. UPLC-PDA-ESI-QqQ analysis revealed caffeoylquinic acid derivatives as the most abundant phenolic compounds in aqueous decoctions. Conclusions: Decoctions of H. sabdariffa or I. sonorae attenuated the adverse effects of a hypercaloric diet via improving glucose homeostasis and triglycerides levels without any observed adverse effects. These decoctions could be helpful for the treatment of metabolic diseases such as obesity and its complications. |
| first_indexed | 2024-12-19T11:59:52Z |
| format | Article |
| id | doaj.art-a83913dc2bdd46c4a61cd180f4ad9f73 |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-12-19T11:59:52Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-a83913dc2bdd46c4a61cd180f4ad9f732022-12-21T20:22:31ZengElsevierPhytomedicine Plus2667-03132022-02-0121100213Effect of herbal decoctions used in Mexican traditional medicine attenuate the adverse effects of a hypercaloric diet.Ana K. Castellanos-Jiménez0Rosalía Reynoso-Camacho1Nuria E. Rocha-Guzmán2María A. Corella-Madueño3Erika A. de los Ríos4Luis M. Salgado5Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada (CICATA), Instituto Politécnico Nacional (IPN), Querétaro, 76090 MexicoUniversidad Autónoma de Querétaro (UAQ), Facultad de Química, Querétaro, 76010 MexicoDepartamento de Ingeniería Química y Bioquímica, Unidad de Posgrado, Investigación y Desarrollo Tecnológico (UPIDET), TecNM/Instituto Tecnológico de Durango, Durango, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de Sonora, 83000 Hermosillo, Sonora, MexicoInstituto de Neurobiología, Universidad Autónoma de México (UNAM), Campus UNAM-Juriquilla, Quéretaro, 76230 MexicoCentro de Investigación en Ciencia Aplicada y Tecnología Avanzada (CICATA), Instituto Politécnico Nacional (IPN), Querétaro, 76090 Mexico; Corresponding author at: CICATA-Querétaro, Instituto Politécnico Nacional (IPN), Cerro Blanco 141, Col. Colinas del Cimatario, Querétaro, 76090 MéxicoBackground: In Mexico, plants as Ibervillea sonorae, Justicia spicigera, Mentha spicata, or Hibiscus sabdariffa are used to prepare decoctions that are traditionally used by the population to prevent or treat several diseases such as obesity and diabetes; scientific evidence is still in process. Purpose: This study evaluated the therapeutic effects of traditional preparations (aqueous decoctions) of four herbs on obesity and its complications, such as insulin resistance, hypertriglyceridemia, and hepatic steatosis induced by a hypercaloric diet. Materials and methods: UPLC-PDA-ESI-QqQ analysis was performed to identify and quantify extractable phenolic constituents of each decoction. Metabolic alterations were induced by high fat and fructose diet in Wistar rats; decoctions were administered for 12 weeks. The effects of herbs on insulin resistant animals, glucose tolerance, insulin resistance, hypertriglyceridemia, and lipid storage in the liver and adipose tissue were assessed by biochemical assays and histological examination. Results: Rats treated with H. sabdariffa preventing body weight gain, improving glucose homeostasis, and decreasing adipocyte size. Meanwhile, the triglycerides and glucose levels in obese rats decreased after I. sonorae treatment. All decoctions showed no adverse effects. UPLC-PDA-ESI-QqQ analysis revealed caffeoylquinic acid derivatives as the most abundant phenolic compounds in aqueous decoctions. Conclusions: Decoctions of H. sabdariffa or I. sonorae attenuated the adverse effects of a hypercaloric diet via improving glucose homeostasis and triglycerides levels without any observed adverse effects. These decoctions could be helpful for the treatment of metabolic diseases such as obesity and its complications.http://www.sciencedirect.com/science/article/pii/S2667031321001950DiabetesInsulin resistanceHerbal decoctionsHypoglycemic effectTraditional medicine |
| spellingShingle | Ana K. Castellanos-Jiménez Rosalía Reynoso-Camacho Nuria E. Rocha-Guzmán María A. Corella-Madueño Erika A. de los Ríos Luis M. Salgado Effect of herbal decoctions used in Mexican traditional medicine attenuate the adverse effects of a hypercaloric diet. Phytomedicine Plus Diabetes Insulin resistance Herbal decoctions Hypoglycemic effect Traditional medicine |
| title | Effect of herbal decoctions used in Mexican traditional medicine attenuate the adverse effects of a hypercaloric diet. |
| title_full | Effect of herbal decoctions used in Mexican traditional medicine attenuate the adverse effects of a hypercaloric diet. |
| title_fullStr | Effect of herbal decoctions used in Mexican traditional medicine attenuate the adverse effects of a hypercaloric diet. |
| title_full_unstemmed | Effect of herbal decoctions used in Mexican traditional medicine attenuate the adverse effects of a hypercaloric diet. |
| title_short | Effect of herbal decoctions used in Mexican traditional medicine attenuate the adverse effects of a hypercaloric diet. |
| title_sort | effect of herbal decoctions used in mexican traditional medicine attenuate the adverse effects of a hypercaloric diet |
| topic | Diabetes Insulin resistance Herbal decoctions Hypoglycemic effect Traditional medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2667031321001950 |
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