Mycobacterium tuberculosis Methyltransferase Rv1515c Can Suppress Host Defense Mechanisms by Modulating Immune Functions Utilizing a Multipronged Mechanism

Mycobacterium tuberculosis Methyltransferase Rv1515c Can Suppress Host Defense Mechanisms by Modulating Immune Functions Utilizing a Multipronged Mechanism

Mycobacterium tuberculosis (M. tb) gene Rv1515c encodes a conserved hypothetical protein exclusively present within organisms of MTB complex and absent in non-pathogenic mycobacteria. In silico analysis revealed that Rv1515c contain S-adenosylmethionine binding site and methyltransferase domain. The...

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Bibliographic Details
Main Authors: Anshu Rani, Anwar Alam, Faraz Ahmad, Manjunath P., Abhinav Saurabh, Sheeba Zarin, Dipendra Kumar Mitra, Seyed E. Hasnain, Nasreen Z. Ehtesham
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
macrophage
multi drug resistance
tuberculosis
tregs
pathogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.906387/full

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