Evaluating Hyperbolic Dispersion Materials for Cancer Detection
Current biosensors have limited application in clinical diagnostics as they lack the high order of specificity needed to detect low molecular analytes, especially in complex fluids (such as blood, urine, and saliva). In contrast, they are resistant to the suppression of non-specific binding. Hyperbo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/6/595 |
| _version_ | 1797595763576930304 |
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| author | Syed Muhammad Sohaib Zafar Igor Iatsunskyi |
| author_facet | Syed Muhammad Sohaib Zafar Igor Iatsunskyi |
| author_sort | Syed Muhammad Sohaib Zafar |
| collection | DOAJ |
| description | Current biosensors have limited application in clinical diagnostics as they lack the high order of specificity needed to detect low molecular analytes, especially in complex fluids (such as blood, urine, and saliva). In contrast, they are resistant to the suppression of non-specific binding. Hyperbolic metamaterials (HMMs) offer highly sought- after label-free detection and quantification techniques to circumvent sensitivity issues as low as 10<sup>5</sup> M concentration in angular sensitivity. This review discusses design strategies in detail and compares nuances in conventional plasmonic techniques to create susceptible miniaturized point-of-care devices. A substantial portion of the review is devoted to developing low optical loss reconfigurable HMM devices for active cancer bioassay platforms. A future perspective of HMM-based biosensors for cancer biomarker detection is provided. |
| first_indexed | 2024-03-11T02:42:02Z |
| format | Article |
| id | doaj.art-a83aa0088b274db1bbc1fcb42c09de9c |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T02:42:02Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-a83aa0088b274db1bbc1fcb42c09de9c2023-11-18T09:32:28ZengMDPI AGBiosensors2079-63742023-05-0113659510.3390/bios13060595Evaluating Hyperbolic Dispersion Materials for Cancer DetectionSyed Muhammad Sohaib Zafar0Igor Iatsunskyi1NanoBioMedical Centre, Adam Mickiewicz University, 3 Wszechnicy Piastowskiej Str., PL-61614 Poznan, PolandNanoBioMedical Centre, Adam Mickiewicz University, 3 Wszechnicy Piastowskiej Str., PL-61614 Poznan, PolandCurrent biosensors have limited application in clinical diagnostics as they lack the high order of specificity needed to detect low molecular analytes, especially in complex fluids (such as blood, urine, and saliva). In contrast, they are resistant to the suppression of non-specific binding. Hyperbolic metamaterials (HMMs) offer highly sought- after label-free detection and quantification techniques to circumvent sensitivity issues as low as 10<sup>5</sup> M concentration in angular sensitivity. This review discusses design strategies in detail and compares nuances in conventional plasmonic techniques to create susceptible miniaturized point-of-care devices. A substantial portion of the review is devoted to developing low optical loss reconfigurable HMM devices for active cancer bioassay platforms. A future perspective of HMM-based biosensors for cancer biomarker detection is provided.https://www.mdpi.com/2079-6374/13/6/595label-free biosensorhyperbolic metamaterials (HMM)cancer biomarkers |
| spellingShingle | Syed Muhammad Sohaib Zafar Igor Iatsunskyi Evaluating Hyperbolic Dispersion Materials for Cancer Detection Biosensors label-free biosensor hyperbolic metamaterials (HMM) cancer biomarkers |
| title | Evaluating Hyperbolic Dispersion Materials for Cancer Detection |
| title_full | Evaluating Hyperbolic Dispersion Materials for Cancer Detection |
| title_fullStr | Evaluating Hyperbolic Dispersion Materials for Cancer Detection |
| title_full_unstemmed | Evaluating Hyperbolic Dispersion Materials for Cancer Detection |
| title_short | Evaluating Hyperbolic Dispersion Materials for Cancer Detection |
| title_sort | evaluating hyperbolic dispersion materials for cancer detection |
| topic | label-free biosensor hyperbolic metamaterials (HMM) cancer biomarkers |
| url | https://www.mdpi.com/2079-6374/13/6/595 |
| work_keys_str_mv | AT syedmuhammadsohaibzafar evaluatinghyperbolicdispersionmaterialsforcancerdetection AT igoriatsunskyi evaluatinghyperbolicdispersionmaterialsforcancerdetection |