Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice
Abstract Tea polyphenols (TP) are the most biologically active components in tea, with antioxidant, antiobesity, and antitumor properties, as well as the ability to modulate the composition and function of intestinal microbiota. This experimental study evaluated the chemical constituents of polyphen...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-06-01
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| Series: | AMB Express |
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| Online Access: | https://doi.org/10.1186/s13568-023-01565-4 |
| _version_ | 1797811288681742336 |
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| author | Ning Wang Chaohua Lan Muhammad Aamer Mehmood Manli He Xiongjun Xiao Linman Li Dalong Liao Kewei Xu Shan Mo Puyu Zhang Xiaoli Zhou Baoxiang Gu Hui Zhu Tao Wu |
| author_facet | Ning Wang Chaohua Lan Muhammad Aamer Mehmood Manli He Xiongjun Xiao Linman Li Dalong Liao Kewei Xu Shan Mo Puyu Zhang Xiaoli Zhou Baoxiang Gu Hui Zhu Tao Wu |
| author_sort | Ning Wang |
| collection | DOAJ |
| description | Abstract Tea polyphenols (TP) are the most biologically active components in tea, with antioxidant, antiobesity, and antitumor properties, as well as the ability to modulate the composition and function of intestinal microbiota. This experimental study evaluated the chemical constituents of polyphenols in Pu-erh (PTP) and Dian Hong tea (DHTP). It also investigated the co-regulatory effects of PTP and DHTP on intestinal flora and liver tissues in mice using 16 S rRNA gene and transcriptome sequencing. The results revealed that DHT had higher concentrations of EGC (epigallocatechin), C (catechin), EC (epicatechin), and EGCG (epigallocatechin gallate). In contrast, PT had higher concentrations of GA (gallic acid), ECG (epicatechin-3-gallate), TF (theaflavin), and TB (theabrownin). PTP and DHTP consumption significantly reduced the rates of weight gain in mice. Microbial community diversity was significantly higher in PTP and DHTP-treated mice than in the control group. Notably, beneficial microbes such as Lactobacillus increased significantly in PTP-treated mice, whereas Lachnospiraceae increased significantly in DHTP-treated mice. Both PTP and DHTP improved the activity of the antioxidant enzymes (SOD) and total antioxidant capacity (T-AOC) in the liver. The transcriptome analysis revealed that the beneficial effects of PTP and DHTP were due to changes in various metabolic pathways, the majority of which were related to antioxidant and lipid metabolism. This study discovered that PTP and DHTP had beneficial effects in mice via the gut-liver axis. |
| first_indexed | 2024-03-13T07:21:27Z |
| format | Article |
| id | doaj.art-a83b0189e2a249a6a27a733cfc81234f |
| institution | Directory Open Access Journal |
| issn | 2191-0855 |
| language | English |
| last_indexed | 2024-03-13T07:21:27Z |
| publishDate | 2023-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj.art-a83b0189e2a249a6a27a733cfc81234f2023-06-04T11:39:17ZengSpringerOpenAMB Express2191-08552023-06-0113111110.1186/s13568-023-01565-4Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in miceNing Wang0Chaohua Lan1Muhammad Aamer Mehmood2Manli He3Xiongjun Xiao4Linman Li5Dalong Liao6Kewei Xu7Shan Mo8Puyu Zhang9Xiaoli Zhou10Baoxiang Gu11Hui Zhu12Tao Wu13College of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringLaboratory Animal Center, Southwest Medical UniversityCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringCollege of Bioengineering, Sichuan University of Science and EngineeringSchool of Food and Biological Engineering, Xihua UniversityAbstract Tea polyphenols (TP) are the most biologically active components in tea, with antioxidant, antiobesity, and antitumor properties, as well as the ability to modulate the composition and function of intestinal microbiota. This experimental study evaluated the chemical constituents of polyphenols in Pu-erh (PTP) and Dian Hong tea (DHTP). It also investigated the co-regulatory effects of PTP and DHTP on intestinal flora and liver tissues in mice using 16 S rRNA gene and transcriptome sequencing. The results revealed that DHT had higher concentrations of EGC (epigallocatechin), C (catechin), EC (epicatechin), and EGCG (epigallocatechin gallate). In contrast, PT had higher concentrations of GA (gallic acid), ECG (epicatechin-3-gallate), TF (theaflavin), and TB (theabrownin). PTP and DHTP consumption significantly reduced the rates of weight gain in mice. Microbial community diversity was significantly higher in PTP and DHTP-treated mice than in the control group. Notably, beneficial microbes such as Lactobacillus increased significantly in PTP-treated mice, whereas Lachnospiraceae increased significantly in DHTP-treated mice. Both PTP and DHTP improved the activity of the antioxidant enzymes (SOD) and total antioxidant capacity (T-AOC) in the liver. The transcriptome analysis revealed that the beneficial effects of PTP and DHTP were due to changes in various metabolic pathways, the majority of which were related to antioxidant and lipid metabolism. This study discovered that PTP and DHTP had beneficial effects in mice via the gut-liver axis.https://doi.org/10.1186/s13568-023-01565-4Tea polyphenolsIntestinal microbiotaLipid metabolismAntioxidative |
| spellingShingle | Ning Wang Chaohua Lan Muhammad Aamer Mehmood Manli He Xiongjun Xiao Linman Li Dalong Liao Kewei Xu Shan Mo Puyu Zhang Xiaoli Zhou Baoxiang Gu Hui Zhu Tao Wu Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice AMB Express Tea polyphenols Intestinal microbiota Lipid metabolism Antioxidative |
| title | Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice |
| title_full | Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice |
| title_fullStr | Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice |
| title_full_unstemmed | Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice |
| title_short | Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice |
| title_sort | effects of pu erh and dian hong tea polyphenols on the gut liver axis in mice |
| topic | Tea polyphenols Intestinal microbiota Lipid metabolism Antioxidative |
| url | https://doi.org/10.1186/s13568-023-01565-4 |
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