Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract
The success of wound treatment is conditioned by the combination of both suitable active ingredients and formulation. Grape seed extract (GSE), a waste by-product obtained by grape processing, is a natural source rich in many phenolic compounds responsible for antioxidant, anti-inflammatory, and ant...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/3/485 |
| _version_ | 1827626682950877184 |
|---|---|
| author | Cinzia Pagano Francesca Luzi Maurizio Ricci Alessandro Di Michele Debora Puglia Maria Rachele Ceccarini Tommaso Beccari Francesca Blasi Lina Cossignani Aurélie Schoubben Sara Primavilla César Antonio Viseras Iborra Luana Perioli |
| author_facet | Cinzia Pagano Francesca Luzi Maurizio Ricci Alessandro Di Michele Debora Puglia Maria Rachele Ceccarini Tommaso Beccari Francesca Blasi Lina Cossignani Aurélie Schoubben Sara Primavilla César Antonio Viseras Iborra Luana Perioli |
| author_sort | Cinzia Pagano |
| collection | DOAJ |
| description | The success of wound treatment is conditioned by the combination of both suitable active ingredients and formulation. Grape seed extract (GSE), a waste by-product obtained by grape processing, is a natural source rich in many phenolic compounds responsible for antioxidant, anti-inflammatory, and antimicrobial activities and for this reason useful to be used in a wound care product. Bioadhesive polymeric patches have been realized by combining acacia gum (AG) and polyvinylpyrrolidone (PVP). Prototypes were prepared by considering different AG/PVP ratios and the most suitable in terms of mechanical and bioadhesion properties resulted in the 9.5/1.0 ratio. This patch was loaded with GSE combined with cyclic dextrin (CD) to obtain the molecular dispersion of the active ingredient in the dried formulation. The loaded patch resulted mechanically resistant and able to release GSE by a sustained mechanism reaching concentrations able to stimulate keratinocytes’ growth, to exert both antibacterial and antioxidant activities. |
| first_indexed | 2024-03-09T13:00:03Z |
| format | Article |
| id | doaj.art-a83b5dbfdc70453284eb1b74b29ff513 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T13:00:03Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a83b5dbfdc70453284eb1b74b29ff5132023-11-30T21:55:34ZengMDPI AGPharmaceutics1999-49232022-02-0114348510.3390/pharmaceutics14030485Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed ExtractCinzia Pagano0Francesca Luzi1Maurizio Ricci2Alessandro Di Michele3Debora Puglia4Maria Rachele Ceccarini5Tommaso Beccari6Francesca Blasi7Lina Cossignani8Aurélie Schoubben9Sara Primavilla10César Antonio Viseras Iborra11Luana Perioli12Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Materials, Environmental Sciences and Urban Planning (SIMAU), 60131 Ancona, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Physics and Geology, University of Perugia, 06123 Perugia, ItalyCivil and Environmental Engineering Department, University of Perugia, UdR INSTM, 05100 Terni, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyIstituto Zooprofilattico dell’Umbria e delle Marche “Togo Rosati”, 06126 Perugia, ItalyDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18071 Granada, SpainDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyThe success of wound treatment is conditioned by the combination of both suitable active ingredients and formulation. Grape seed extract (GSE), a waste by-product obtained by grape processing, is a natural source rich in many phenolic compounds responsible for antioxidant, anti-inflammatory, and antimicrobial activities and for this reason useful to be used in a wound care product. Bioadhesive polymeric patches have been realized by combining acacia gum (AG) and polyvinylpyrrolidone (PVP). Prototypes were prepared by considering different AG/PVP ratios and the most suitable in terms of mechanical and bioadhesion properties resulted in the 9.5/1.0 ratio. This patch was loaded with GSE combined with cyclic dextrin (CD) to obtain the molecular dispersion of the active ingredient in the dried formulation. The loaded patch resulted mechanically resistant and able to release GSE by a sustained mechanism reaching concentrations able to stimulate keratinocytes’ growth, to exert both antibacterial and antioxidant activities.https://www.mdpi.com/1999-4923/14/3/485acacia gumwoundgrape seed extractpatchbioadhesion |
| spellingShingle | Cinzia Pagano Francesca Luzi Maurizio Ricci Alessandro Di Michele Debora Puglia Maria Rachele Ceccarini Tommaso Beccari Francesca Blasi Lina Cossignani Aurélie Schoubben Sara Primavilla César Antonio Viseras Iborra Luana Perioli Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract Pharmaceutics acacia gum wound grape seed extract patch bioadhesion |
| title | Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract |
| title_full | Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract |
| title_fullStr | Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract |
| title_full_unstemmed | Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract |
| title_short | Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract |
| title_sort | wound dressing combination of acacia gum pvp cyclic dextrin in bioadhesive patches loaded with grape seed extract |
| topic | acacia gum wound grape seed extract patch bioadhesion |
| url | https://www.mdpi.com/1999-4923/14/3/485 |
| work_keys_str_mv | AT cinziapagano wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT francescaluzi wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT maurizioricci wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT alessandrodimichele wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT deborapuglia wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT mariarachelececcarini wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT tommasobeccari wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT francescablasi wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT linacossignani wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT aurelieschoubben wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT saraprimavilla wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT cesarantonioviserasiborra wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract AT luanaperioli wounddressingcombinationofacaciagumpvpcyclicdextrininbioadhesivepatchesloadedwithgrapeseedextract |