Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cells
A Japanese herbal (Kampo, [INSIDE:1]) medicine, [INSIDE:2] (juzentaihoto/Shi-Quan-Da-Bu-Tang), is one of the nourishing agents, a so-called “[INSIDE:3] (Hozai/Bu-Ji),” that is used for improving disturbance and imbalances in the homeostatic condition of the body. This formulation is orally administe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | World Journal of Traditional Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.wjtcm.net/article.asp?issn=2311-8571;year=2017;volume=3;issue=4;spage=26;epage=45;aulast=Saiki |
| _version_ | 1818552141115031552 |
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| author | Ikuo Saiki Satoru Yokoyama Yoshihiro Hayakawa |
| author_facet | Ikuo Saiki Satoru Yokoyama Yoshihiro Hayakawa |
| author_sort | Ikuo Saiki |
| collection | DOAJ |
| description | A Japanese herbal (Kampo, [INSIDE:1]) medicine, [INSIDE:2] (juzentaihoto/Shi-Quan-Da-Bu-Tang), is one of the nourishing agents, a so-called “[INSIDE:3] (Hozai/Bu-Ji),” that is used for improving disturbance and imbalances in the homeostatic condition of the body. This formulation is orally administered to patients in various weakened states, including postsurgery patients and patients with chronic illness, where it can alleviate general symptoms such as extreme fatigue, pale complexion, loss of appetite, dry or scaly skin, night sweating, and dryness of the mouth. Recently, juzentaihoto/Shi-Quan-Da-Bu-Tang has been shown to have a variety of biological activities, including activation of natural killer cells and macrophages, cytokine induction, antibody production, antitumor effects in combination with surgical excision or other drugs, and protection against the adverse effects of anticancer drugs and radiation, including immunosuppression and bone marrow toxicity. This article focuses on the antitumor and antimetastatic properties of some Kampo medicines and mainly describes the effects of juzentaihoto and its related formulations on tumor development, progression, and metastasis in vivo. We also discuss the inhibitory mechanism of action and the importance of the prescription and constituent crude drugs in determining the efficacy. |
| first_indexed | 2024-12-12T09:09:18Z |
| format | Article |
| id | doaj.art-a83c587f650f42088a27193e6609dbb5 |
| institution | Directory Open Access Journal |
| issn | 2311-8571 2589-2894 |
| language | English |
| last_indexed | 2024-12-12T09:09:18Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj.art-a83c587f650f42088a27193e6609dbb52022-12-22T00:29:34ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712589-28942017-01-0134264510.4103/wjtcm.wjtcm_3_17Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cellsIkuo SaikiSatoru YokoyamaYoshihiro HayakawaA Japanese herbal (Kampo, [INSIDE:1]) medicine, [INSIDE:2] (juzentaihoto/Shi-Quan-Da-Bu-Tang), is one of the nourishing agents, a so-called “[INSIDE:3] (Hozai/Bu-Ji),” that is used for improving disturbance and imbalances in the homeostatic condition of the body. This formulation is orally administered to patients in various weakened states, including postsurgery patients and patients with chronic illness, where it can alleviate general symptoms such as extreme fatigue, pale complexion, loss of appetite, dry or scaly skin, night sweating, and dryness of the mouth. Recently, juzentaihoto/Shi-Quan-Da-Bu-Tang has been shown to have a variety of biological activities, including activation of natural killer cells and macrophages, cytokine induction, antibody production, antitumor effects in combination with surgical excision or other drugs, and protection against the adverse effects of anticancer drugs and radiation, including immunosuppression and bone marrow toxicity. This article focuses on the antitumor and antimetastatic properties of some Kampo medicines and mainly describes the effects of juzentaihoto and its related formulations on tumor development, progression, and metastasis in vivo. We also discuss the inhibitory mechanism of action and the importance of the prescription and constituent crude drugs in determining the efficacy.http://www.wjtcm.net/article.asp?issn=2311-8571;year=2017;volume=3;issue=4;spage=26;epage=45;aulast=SaikiEpithelial-to-mesenchymal transitionhigh-performance liquid chromatography pattern analysisJapanese herbal (Kampo) medicinejuzentaihoto/Shi-Quan-Da-Bu-Tangmacrophagesmalignant progressionnatural killer cellsshimotsuto/Si-Wu-Tangtumor metastasistumor vaccine |
| spellingShingle | Ikuo Saiki Satoru Yokoyama Yoshihiro Hayakawa Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cells World Journal of Traditional Chinese Medicine Epithelial-to-mesenchymal transition high-performance liquid chromatography pattern analysis Japanese herbal (Kampo) medicine juzentaihoto/Shi-Quan-Da-Bu-Tang macrophages malignant progression natural killer cells shimotsuto/Si-Wu-Tang tumor metastasis tumor vaccine |
| title | Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cells |
| title_full | Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cells |
| title_fullStr | Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cells |
| title_full_unstemmed | Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cells |
| title_short | Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cells |
| title_sort | effect of juzentaihoto shi quan da bu tang on malignant progression and metastasis of tumor cells |
| topic | Epithelial-to-mesenchymal transition high-performance liquid chromatography pattern analysis Japanese herbal (Kampo) medicine juzentaihoto/Shi-Quan-Da-Bu-Tang macrophages malignant progression natural killer cells shimotsuto/Si-Wu-Tang tumor metastasis tumor vaccine |
| url | http://www.wjtcm.net/article.asp?issn=2311-8571;year=2017;volume=3;issue=4;spage=26;epage=45;aulast=Saiki |
| work_keys_str_mv | AT ikuosaiki effectofjuzentaihotoshiquandabutangonmalignantprogressionandmetastasisoftumorcells AT satoruyokoyama effectofjuzentaihotoshiquandabutangonmalignantprogressionandmetastasisoftumorcells AT yoshihirohayakawa effectofjuzentaihotoshiquandabutangonmalignantprogressionandmetastasisoftumorcells |