The role of NKT cells in gastrointestinal cancers
Gastrointestinal (GI) cancers represent a complex array of cancers that affect the digestive system. This includes liver, pancreatic, colon, rectal, anal, gastric, esophageal, intestinal and gallbladder cancer. Patients diagnosed with certain GI cancers typically have low survival rates, so new ther...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-01-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/2162402X.2021.2009666 |
| _version_ | 1798034068449787904 |
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| author | Julian Burks Purevdorj B. Olkhanud Jay A. Berzofsky |
| author_facet | Julian Burks Purevdorj B. Olkhanud Jay A. Berzofsky |
| author_sort | Julian Burks |
| collection | DOAJ |
| description | Gastrointestinal (GI) cancers represent a complex array of cancers that affect the digestive system. This includes liver, pancreatic, colon, rectal, anal, gastric, esophageal, intestinal and gallbladder cancer. Patients diagnosed with certain GI cancers typically have low survival rates, so new therapeutic approaches are needed. A potential approach is to harness the potent immunoregulatory properties of natural killer T (NKT) cells which are true T cells, not natural killer (NK) cells, that recognize lipid instead of peptide antigens presented by the non-classical major histocompatibility (MHC) molecule CD1d. The NKT cell subpopulation is known to play a vital role in tumor immunity by bridging innate and adaptive immune responses. In GI cancers, NKT cells can contribute to either antitumor or protumor immunity depending on the cytokine profile expressed and type of cancer. This review discusses the complexities of the role of NKT cells in liver, colon, pancreatic and gastric cancers with an emphasis on type I NKT cells. |
| first_indexed | 2024-04-11T20:39:08Z |
| format | Article |
| id | doaj.art-a83e8ee5bc5e4d7da25be75f73d5b7ad |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-04-11T20:39:08Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-a83e8ee5bc5e4d7da25be75f73d5b7ad2022-12-22T04:04:17ZengTaylor & Francis GroupOncoImmunology2162-402X2022-01-0111110.1080/2162402X.2021.20096662009666The role of NKT cells in gastrointestinal cancersJulian Burks0Purevdorj B. Olkhanud1Jay A. Berzofsky2National Cancer Institute, National Institutes of HealthNational Cancer Institute, National Institutes of HealthNational Cancer Institute, National Institutes of HealthGastrointestinal (GI) cancers represent a complex array of cancers that affect the digestive system. This includes liver, pancreatic, colon, rectal, anal, gastric, esophageal, intestinal and gallbladder cancer. Patients diagnosed with certain GI cancers typically have low survival rates, so new therapeutic approaches are needed. A potential approach is to harness the potent immunoregulatory properties of natural killer T (NKT) cells which are true T cells, not natural killer (NK) cells, that recognize lipid instead of peptide antigens presented by the non-classical major histocompatibility (MHC) molecule CD1d. The NKT cell subpopulation is known to play a vital role in tumor immunity by bridging innate and adaptive immune responses. In GI cancers, NKT cells can contribute to either antitumor or protumor immunity depending on the cytokine profile expressed and type of cancer. This review discusses the complexities of the role of NKT cells in liver, colon, pancreatic and gastric cancers with an emphasis on type I NKT cells.http://dx.doi.org/10.1080/2162402X.2021.2009666gastrointestinalcancersnatural killer t cells |
| spellingShingle | Julian Burks Purevdorj B. Olkhanud Jay A. Berzofsky The role of NKT cells in gastrointestinal cancers OncoImmunology gastrointestinal cancers natural killer t cells |
| title | The role of NKT cells in gastrointestinal cancers |
| title_full | The role of NKT cells in gastrointestinal cancers |
| title_fullStr | The role of NKT cells in gastrointestinal cancers |
| title_full_unstemmed | The role of NKT cells in gastrointestinal cancers |
| title_short | The role of NKT cells in gastrointestinal cancers |
| title_sort | role of nkt cells in gastrointestinal cancers |
| topic | gastrointestinal cancers natural killer t cells |
| url | http://dx.doi.org/10.1080/2162402X.2021.2009666 |
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