Preservation of vascular endothelial glycocalyx and barrier by activation of adenosine A2A receptor (A2AR) improved renal dysfunction in cirrhotic rats

Preservation of vascular endothelial glycocalyx and barrier by activation of adenosine A2A receptor (A2AR) improved renal dysfunction in cirrhotic rats

Cirrhosis-related hepatic and renal endothelial dysfunction is characterized by macrophage-endothelium adhesion-mediated inflammation, glycocalyx/barrier damage, and impaired vasodilation. Activation of adenosine A2A receptor (A2AR) protects cirrhotic rats from impairment of hepatic microcirculation...

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Bibliographic Details
Main Authors:	Chia-Chang Huang, Hsiao-Chin Shen, Roger Lin, Ying-Ying Yang, Yun-Chien Chang, Tsai-Ling Liao, Shiang-Fen Huang, Han-Chieh Lin, Ming-Chih Hou
Format:	Article
Language:	English
Published:	Elsevier 2023-05-01
Series:	Journal of Pharmacological Sciences
Subjects:	Adenosine A2A receptor Cirrhosis-related hepatic and renal endothelial dysfunction Macrophage Endothelial glycocalyx damage Barrier Inflammatory
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861323000166

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