ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer
Objective: This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress–related genes EIF2AK3/PERK, HSPA5/GRP78, and DDIT3/CHOP polymorphisms and the risk of lung cancer.Methods: Six single-nucleotide polymorphisms (SNPs) of EIF2AK3, HSPA5, and DDIT3 were genotyped in 620...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.938787/full |
| _version_ | 1811217589390540800 |
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| author | Yongshi Liu Xiaohua Liang Hongpei Zhang Jiajia Dong Yan Zhang Juan Wang Chunmei Li Xiangbing Xin Yan Li |
| author_facet | Yongshi Liu Xiaohua Liang Hongpei Zhang Jiajia Dong Yan Zhang Juan Wang Chunmei Li Xiangbing Xin Yan Li |
| author_sort | Yongshi Liu |
| collection | DOAJ |
| description | Objective: This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress–related genes EIF2AK3/PERK, HSPA5/GRP78, and DDIT3/CHOP polymorphisms and the risk of lung cancer.Methods: Six single-nucleotide polymorphisms (SNPs) of EIF2AK3, HSPA5, and DDIT3 were genotyped in 620 cases and 620 controls using a MassARRAY platform.Results: The minor allele A of rs6750998 was a protective allele against the risk of lung cancer (p < 0.001), while the minor alleles of rs867529, rs391957, and rs697221 were all risk alleles that may lead to multiplied risk of the disease (rprs867529 = 0.002; prs391957 = 0.015; prs697221 < 0.001). Moreover, the rs6750998-TA/AA genotypes were protective genotypes against the risk of lung cancer (p = 0.005); however, the rs867529-GC/CC, rs391957-CC, and rs697221-GA/AA genotypes were associated with elevated lung cancer risk (prs867529 = 0.003, prs391957 = 0.028, and prs697221 = 0.0001). In addition, EIF2AK3-rs6750998 was associated with a decreased risk of lung cancer under dominant, recessive, and log-additive models (p < 0.05). By contrast, the EIF2AK3-rs867529 was correlated with an increased risk of the disease under dominant and log-additive models (p = 0.001). Moreover, HSPA5-rs391957 was related to an elevated risk of the disease under recessive and log-additive models (p < 0.02). DDIT3-rs697221 was identified to have a significant association with the risk of lung cancer under all three genetic models (p < 0.01).Conclusion: Our results provide new insights on the role of the ER stress–related genes EIF2AK3, HSPA5, and DDIT3 polymorphisms for lung cancer risk. |
| first_indexed | 2024-04-12T06:57:24Z |
| format | Article |
| id | doaj.art-a84019527b1b4d888afa96f531218352 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T06:57:24Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj.art-a84019527b1b4d888afa96f5312183522022-12-22T03:43:06ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-07-011310.3389/fgene.2022.938787938787ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung CancerYongshi Liu0Xiaohua Liang1Hongpei Zhang2Jiajia Dong3Yan Zhang4Juan Wang5Chunmei Li6Xiangbing Xin7Yan Li8Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Respiratory Medicine, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Respiratory Medicine, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Respiratory Medicine, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Respiratory Medicine, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, ChinaObjective: This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress–related genes EIF2AK3/PERK, HSPA5/GRP78, and DDIT3/CHOP polymorphisms and the risk of lung cancer.Methods: Six single-nucleotide polymorphisms (SNPs) of EIF2AK3, HSPA5, and DDIT3 were genotyped in 620 cases and 620 controls using a MassARRAY platform.Results: The minor allele A of rs6750998 was a protective allele against the risk of lung cancer (p < 0.001), while the minor alleles of rs867529, rs391957, and rs697221 were all risk alleles that may lead to multiplied risk of the disease (rprs867529 = 0.002; prs391957 = 0.015; prs697221 < 0.001). Moreover, the rs6750998-TA/AA genotypes were protective genotypes against the risk of lung cancer (p = 0.005); however, the rs867529-GC/CC, rs391957-CC, and rs697221-GA/AA genotypes were associated with elevated lung cancer risk (prs867529 = 0.003, prs391957 = 0.028, and prs697221 = 0.0001). In addition, EIF2AK3-rs6750998 was associated with a decreased risk of lung cancer under dominant, recessive, and log-additive models (p < 0.05). By contrast, the EIF2AK3-rs867529 was correlated with an increased risk of the disease under dominant and log-additive models (p = 0.001). Moreover, HSPA5-rs391957 was related to an elevated risk of the disease under recessive and log-additive models (p < 0.02). DDIT3-rs697221 was identified to have a significant association with the risk of lung cancer under all three genetic models (p < 0.01).Conclusion: Our results provide new insights on the role of the ER stress–related genes EIF2AK3, HSPA5, and DDIT3 polymorphisms for lung cancer risk.https://www.frontiersin.org/articles/10.3389/fgene.2022.938787/fulllung cancergene polymorphismssingle-nucleotide polymorphismsendoplasmic reticulum stresscase–control study |
| spellingShingle | Yongshi Liu Xiaohua Liang Hongpei Zhang Jiajia Dong Yan Zhang Juan Wang Chunmei Li Xiangbing Xin Yan Li ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer Frontiers in Genetics lung cancer gene polymorphisms single-nucleotide polymorphisms endoplasmic reticulum stress case–control study |
| title | ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer |
| title_full | ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer |
| title_fullStr | ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer |
| title_full_unstemmed | ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer |
| title_short | ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer |
| title_sort | er stress related genes eif2ak3 hspa5 and ddit3 polymorphisms are associated with risk of lung cancer |
| topic | lung cancer gene polymorphisms single-nucleotide polymorphisms endoplasmic reticulum stress case–control study |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.938787/full |
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