Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study
Abstract Biliary tract cancer (BTC) has been inconsistently identified according to its location in epidemiological and clinical studies. This study retrospectively reviewed the treatment pattern and prognosis of BTC according to tumor location using the Korea Central Cancer Registry data of 97,676...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13605-3 |
| _version_ | 1818239731541999616 |
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| author | Mee Joo Kang Jiwon Lim Sung-Sik Han Hyeong Min Park Sun-Whe Kim Woo Jin Lee Sang Myung Woo Tae Hyun Kim Young-Joo Won Sang-Jae Park |
| author_facet | Mee Joo Kang Jiwon Lim Sung-Sik Han Hyeong Min Park Sun-Whe Kim Woo Jin Lee Sang Myung Woo Tae Hyun Kim Young-Joo Won Sang-Jae Park |
| author_sort | Mee Joo Kang |
| collection | DOAJ |
| description | Abstract Biliary tract cancer (BTC) has been inconsistently identified according to its location in epidemiological and clinical studies. This study retrospectively reviewed the treatment pattern and prognosis of BTC according to tumor location using the Korea Central Cancer Registry data of 97,676 patients with BTC from 2006 to 2017. The proportion of localized and regional Surveillance, Epidemiology, and End Results (SEER) stage was the highest in ampulla of Vater (AoV, 78.2%) cancer, followed by extrahepatic bile duct (BD, 68.3%), gallbladder (GB, 52.6%), and intrahepatic BD (49.5%) cancers. Overall, the “no active anti-cancer treatment” rate was the highest in intrahepatic BD (52.8%), followed by extrahepatic BD (49.5%), GB (39.6%), and AoV cancers (28.9%). The 5-year relative survival rate was the highest in AoV (48.5%), followed by GB (28.5%), extrahepatic BD (19.9%), and intrahepatic BD (10.8%) cancers, which significantly improved over time, except for intrahepatic BD cancer. In the localized and regional stage, older patients had a higher risk of receiving no active anti-cancer treatment in each tumor location after adjusting for period and sex. BTC statistics should be reported separately according to tumor location due to its distinct SEER stage distribution, treatment pattern, and prognosis. Care should be taken in elderly patients to reduce the rate of no active anti-cancer treatment. |
| first_indexed | 2024-12-12T13:02:13Z |
| format | Article |
| id | doaj.art-a84078d4dc7e4f4e8dfe3a83fa85f026 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T13:02:13Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a84078d4dc7e4f4e8dfe3a83fa85f0262022-12-22T00:23:46ZengNature PortfolioScientific Reports2045-23222022-06-0112111010.1038/s41598-022-13605-3Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based studyMee Joo Kang0Jiwon Lim1Sung-Sik Han2Hyeong Min Park3Sun-Whe Kim4Woo Jin Lee5Sang Myung Woo6Tae Hyun Kim7Young-Joo Won8Sang-Jae Park9Center for Liver and Pancreatobiliary Cancer, National Cancer CenterDivision of Cancer Registration and Surveillance, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterDivision of Cancer Registration and Surveillance, National Cancer CenterCenter for Liver and Pancreatobiliary Cancer, National Cancer CenterAbstract Biliary tract cancer (BTC) has been inconsistently identified according to its location in epidemiological and clinical studies. This study retrospectively reviewed the treatment pattern and prognosis of BTC according to tumor location using the Korea Central Cancer Registry data of 97,676 patients with BTC from 2006 to 2017. The proportion of localized and regional Surveillance, Epidemiology, and End Results (SEER) stage was the highest in ampulla of Vater (AoV, 78.2%) cancer, followed by extrahepatic bile duct (BD, 68.3%), gallbladder (GB, 52.6%), and intrahepatic BD (49.5%) cancers. Overall, the “no active anti-cancer treatment” rate was the highest in intrahepatic BD (52.8%), followed by extrahepatic BD (49.5%), GB (39.6%), and AoV cancers (28.9%). The 5-year relative survival rate was the highest in AoV (48.5%), followed by GB (28.5%), extrahepatic BD (19.9%), and intrahepatic BD (10.8%) cancers, which significantly improved over time, except for intrahepatic BD cancer. In the localized and regional stage, older patients had a higher risk of receiving no active anti-cancer treatment in each tumor location after adjusting for period and sex. BTC statistics should be reported separately according to tumor location due to its distinct SEER stage distribution, treatment pattern, and prognosis. Care should be taken in elderly patients to reduce the rate of no active anti-cancer treatment.https://doi.org/10.1038/s41598-022-13605-3 |
| spellingShingle | Mee Joo Kang Jiwon Lim Sung-Sik Han Hyeong Min Park Sun-Whe Kim Woo Jin Lee Sang Myung Woo Tae Hyun Kim Young-Joo Won Sang-Jae Park Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study Scientific Reports |
| title | Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study |
| title_full | Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study |
| title_fullStr | Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study |
| title_full_unstemmed | Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study |
| title_short | Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study |
| title_sort | distinct prognosis of biliary tract cancer according to tumor location stage and treatment a population based study |
| url | https://doi.org/10.1038/s41598-022-13605-3 |
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