Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP‐1
Abstract The TIGG model is the first model to integrate glucose and insulin regulation, incretin effect, and triglyceride (TG) response in the lipoprotein subclasses of chylomicrons and VLDL‐V6. This model described the response following a high‐fat meal in individuals who are lean, obese, and very...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.13030 |
| _version_ | 1797657203860045824 |
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| author | Jennifer Leohr Maria C. Kjellsson |
| author_facet | Jennifer Leohr Maria C. Kjellsson |
| author_sort | Jennifer Leohr |
| collection | DOAJ |
| description | Abstract The TIGG model is the first model to integrate glucose and insulin regulation, incretin effect, and triglyceride (TG) response in the lipoprotein subclasses of chylomicrons and VLDL‐V6. This model described the response following a high‐fat meal in individuals who are lean, obese, and very obese and provided insights into the possible regulation of glucose homeostasis in the extended period following a meal. Often, total TGs are analyzed within clinical studies, instead of lipoprotein subclasses. We extended the existing TIGG model to capture the observed total TGs and determined if this model could be used to predict the postprandial TG response of chylomicron and VLDL‐V6 when only total TGs are available. To assess if the lipoprotein distinction was important for the model, a second model (tTIGG) was developed using only the postprandial response in total TGs, instead of postprandial TG response in chylomicrons and VLDL‐V6. The two models were compared on their predictability to characterize the postprandial response of glucose, insulin, and active GLP‐1. Both models were able to characterize the postprandial TG response in individuals who are lean, obese, or very obese following a high‐fat meal. The extended TIGG model resulted in a better model fit of the glucose data compared to the tTIGG model, indicating that chylomicron and VLDL‐V6 provided additional information compared to total TGs. Furthermore, the expanded TIGG model was able to predict the postprandial TG response of chylomicrons and VLDL‐V6 using the total TGs and could therefore be used in studies where only total TGs were collected. |
| first_indexed | 2024-03-11T17:41:03Z |
| format | Article |
| id | doaj.art-a840e8429e754b49abbd787a0d074e29 |
| institution | Directory Open Access Journal |
| issn | 2163-8306 |
| language | English |
| last_indexed | 2024-03-11T17:41:03Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | CPT: Pharmacometrics & Systems Pharmacology |
| spelling | doaj.art-a840e8429e754b49abbd787a0d074e292023-10-18T10:22:39ZengWileyCPT: Pharmacometrics & Systems Pharmacology2163-83062023-10-0112101529154010.1002/psp4.13030Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP‐1Jennifer Leohr0Maria C. Kjellsson1Department of Pharmacokinetics/Pharmacodynamics, Lilly Research Laboratories Lilly Corporate Center Indianapolis Indiana USAPharmacometrics Research Group, Department of Pharmacy Uppsala University Uppsala SwedenAbstract The TIGG model is the first model to integrate glucose and insulin regulation, incretin effect, and triglyceride (TG) response in the lipoprotein subclasses of chylomicrons and VLDL‐V6. This model described the response following a high‐fat meal in individuals who are lean, obese, and very obese and provided insights into the possible regulation of glucose homeostasis in the extended period following a meal. Often, total TGs are analyzed within clinical studies, instead of lipoprotein subclasses. We extended the existing TIGG model to capture the observed total TGs and determined if this model could be used to predict the postprandial TG response of chylomicron and VLDL‐V6 when only total TGs are available. To assess if the lipoprotein distinction was important for the model, a second model (tTIGG) was developed using only the postprandial response in total TGs, instead of postprandial TG response in chylomicrons and VLDL‐V6. The two models were compared on their predictability to characterize the postprandial response of glucose, insulin, and active GLP‐1. Both models were able to characterize the postprandial TG response in individuals who are lean, obese, or very obese following a high‐fat meal. The extended TIGG model resulted in a better model fit of the glucose data compared to the tTIGG model, indicating that chylomicron and VLDL‐V6 provided additional information compared to total TGs. Furthermore, the expanded TIGG model was able to predict the postprandial TG response of chylomicrons and VLDL‐V6 using the total TGs and could therefore be used in studies where only total TGs were collected.https://doi.org/10.1002/psp4.13030 |
| spellingShingle | Jennifer Leohr Maria C. Kjellsson Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP‐1 CPT: Pharmacometrics & Systems Pharmacology |
| title | Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP‐1 |
| title_full | Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP‐1 |
| title_fullStr | Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP‐1 |
| title_full_unstemmed | Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP‐1 |
| title_short | Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP‐1 |
| title_sort | evaluation of postprandial total triglycerides within the tigg model for characterizing postprandial response of glucose insulin and glp 1 |
| url | https://doi.org/10.1002/psp4.13030 |
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