Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder.

Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder.

Obsessive compulsive disorder (OCD) is substantially heritable, but few molecular genetic risk factors have been identified. Knockout mice lacking SLIT and NTRK-Like Family, Member 5 (SLITRK5) display OCD-like phenotypes including serotonin reuptake inhibitor-sensitive pathologic grooming, and corti...

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Main Authors: Minseok Song, Carol A Mathews, S Evelyn Stewart, Sergey V Shmelkov, Jason G Mezey, Juan L Rodriguez-Flores, Steven A Rasmussen, Jennifer C Britton, Yong-Seok Oh, John T Walkup, Francis S Lee, Charles E Glatt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5234816?pdf=render

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