Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder
Objectives: This study aims at researching the inflammatory cells and their ratios as inflammation markers in different phases of patients with bipolar disorder (BD). Methods: In this retrospective study, 79 manic, 61 depressed, 59 euthymic drug-naive patients with BD, and 86 control subjects have b...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AVES
2017-07-01
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| Series: | Psychiatry and Clinical Psychopharmacology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/24750573.2017.1338822 |
| _version_ | 1797920813754613760 |
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| author | Medine Giynas Ayhan Ismet Esra Cicek Ikbal Inanli Ali Metehan Caliskan Seda Kirci Ercan Ibrahim Eren |
| author_facet | Medine Giynas Ayhan Ismet Esra Cicek Ikbal Inanli Ali Metehan Caliskan Seda Kirci Ercan Ibrahim Eren |
| author_sort | Medine Giynas Ayhan |
| collection | DOAJ |
| description | Objectives: This study aims at researching the inflammatory cells and their ratios as inflammation markers in different phases of patients with bipolar disorder (BD). Methods: In this retrospective study, 79 manic, 61 depressed, 59 euthymic drug-naive patients with BD, and 86 control subjects have been evaluated for their complete blood count. Results: Neutrophil/lymphocyte ratio (NLR) was found to be significantly higher in manic, euthymic, and depressed patients with BD compared to control group. However, no difference was found between all patient and control groups regarding platelet/lymphocyte ratio (PLR). There was no difference among different phases of patient groups in terms of NLR and PLR. Conclusions: Our findings suggest that inflammatory process may have a role in all mood episodes of BD and NLR may be a useful trait inflammation marker for BD independent of mood episodes. However, further studies need to be conducted on the effect of inflammatory mechanisms on mood states of BD. |
| first_indexed | 2024-04-10T14:06:50Z |
| format | Article |
| id | doaj.art-a84409048e5248c6a483c40aebdba068 |
| institution | Directory Open Access Journal |
| issn | 2475-0573 2475-0581 |
| language | English |
| last_indexed | 2024-04-10T14:06:50Z |
| publishDate | 2017-07-01 |
| publisher | AVES |
| record_format | Article |
| series | Psychiatry and Clinical Psychopharmacology |
| spelling | doaj.art-a84409048e5248c6a483c40aebdba0682023-02-15T16:09:56ZengAVESPsychiatry and Clinical Psychopharmacology2475-05732475-05812017-07-0127327828210.1080/24750573.2017.13388221338822Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorderMedine Giynas Ayhan0Ismet Esra Cicek1Ikbal Inanli2Ali Metehan Caliskan3Seda Kirci Ercan4Ibrahim Eren5Konya Training and Research HospitalKonya Training and Research HospitalKonya Training and Research HospitalKonya Training and Research HospitalKonya Training and Research HospitalKonya Training and Research HospitalObjectives: This study aims at researching the inflammatory cells and their ratios as inflammation markers in different phases of patients with bipolar disorder (BD). Methods: In this retrospective study, 79 manic, 61 depressed, 59 euthymic drug-naive patients with BD, and 86 control subjects have been evaluated for their complete blood count. Results: Neutrophil/lymphocyte ratio (NLR) was found to be significantly higher in manic, euthymic, and depressed patients with BD compared to control group. However, no difference was found between all patient and control groups regarding platelet/lymphocyte ratio (PLR). There was no difference among different phases of patient groups in terms of NLR and PLR. Conclusions: Our findings suggest that inflammatory process may have a role in all mood episodes of BD and NLR may be a useful trait inflammation marker for BD independent of mood episodes. However, further studies need to be conducted on the effect of inflammatory mechanisms on mood states of BD.http://dx.doi.org/10.1080/24750573.2017.1338822Bipolar disorderinflammationneutrophil/lymphocyte ratioplatelet/lymphocyte ratio |
| spellingShingle | Medine Giynas Ayhan Ismet Esra Cicek Ikbal Inanli Ali Metehan Caliskan Seda Kirci Ercan Ibrahim Eren Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder Psychiatry and Clinical Psychopharmacology Bipolar disorder inflammation neutrophil/lymphocyte ratio platelet/lymphocyte ratio |
| title | Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder |
| title_full | Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder |
| title_fullStr | Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder |
| title_full_unstemmed | Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder |
| title_short | Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder |
| title_sort | neutrophil lymphocyte and platelet lymphocyte ratios in all mood states of bipolar disorder |
| topic | Bipolar disorder inflammation neutrophil/lymphocyte ratio platelet/lymphocyte ratio |
| url | http://dx.doi.org/10.1080/24750573.2017.1338822 |
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