Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling

Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling

Type I interferons (IFNs) are potent inhibitors of viral replication. Here, we reformatted the natural murine and human type I interferon-α/β receptors IFNAR1 and IFNAR2 into fully synthetic biological switches. The transmembrane and intracellular domains of natural IFNAR1 and IFNAR2 were conserved,...

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Bibliographic Details
Main Authors: Nele Zoellner, Noémi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Jürgen Scheller
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Microbiology
Subjects:
interferon
synthetic
cytokine
virus
nanobody
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.947169/full

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