Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids
Abstract Background The global spread of coronavirus disease 2019 (COVID‐19) has resulted in a significant disease burden, yet asthma patients do not have the expected high morbidity and mortality rates in the pandemics of COVID‐19. Objective To find the difference of angiotensin‐converting enzyme 2...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.922 |
| _version_ | 1797770348945473536 |
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| author | Xiang Ma Lesen Liu Jing Sun Yun Zhang Yanqin Liu Miao Liu Bing Wang Yuna Chang Yuling Han Zhongtao Gai |
| author_facet | Xiang Ma Lesen Liu Jing Sun Yun Zhang Yanqin Liu Miao Liu Bing Wang Yuna Chang Yuling Han Zhongtao Gai |
| author_sort | Xiang Ma |
| collection | DOAJ |
| description | Abstract Background The global spread of coronavirus disease 2019 (COVID‐19) has resulted in a significant disease burden, yet asthma patients do not have the expected high morbidity and mortality rates in the pandemics of COVID‐19. Objective To find the difference of angiotensin‐converting enzyme 2 (ACE2) in asthma and nonasthma children and evaluate the effect of inhaled corticosteroids (ICS) on its expression. Methods The ACE2, immunoglobulin E (IgE), and eosinophils were tested in different children. Results A total of 157 children aged 3–16 years were enrolled. The expression of ACE2 in asthma children were lower than nonasthma children (T = −2.512, p = .013). Allergic nonasthma children had a significant higher ACE2 expression than children with allergic asthma (p = .013) and nonallergic asthma (p = .029). The expression of ACE2 had no significant difference between first‐diagnosed asthma children and that had been treated with ICS for ≥6 months (F = 0.028, p = .598). The allergic asthma children showed a significantly higher eosinophils cells (EC) count than the allergic nonasthma (W = 200, p < .001) and nonallergic nonasthma children (W = 1089, p < .001). Nonallergic asthma children also had a significant higher EC count than the allergic non‐asthma (W = 182.5, p < .001) and nonallergic non‐asthma (W = 200.5, p < .001) children. There was no significant difference in IgE levels between asthmatic children and non‐asthmatic children (W = 2792.5, p = .18). Conclusion Circulating ACE2 levels in asthmatic children were lower than those in non‐asthmatic children and ICS treatment for ≥6 months did not affect the expression of ACE2 in peripheral blood in the asthma children. |
| first_indexed | 2024-03-12T21:22:00Z |
| format | Article |
| id | doaj.art-a8446c66f37f4690a0270ead955cf021 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-12T21:22:00Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-a8446c66f37f4690a0270ead955cf0212023-07-28T17:22:31ZengWileyImmunity, Inflammation and Disease2050-45272023-07-01117n/an/a10.1002/iid3.922Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroidsXiang Ma0Lesen Liu1Jing Sun2Yun Zhang3Yanqin Liu4Miao Liu5Bing Wang6Yuna Chang7Yuling Han8Zhongtao Gai9Department of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan ChinaDepartment of Infectious Diseases Huaiyin People's Hospital Jinan ChinaDepartment of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan ChinaDepartment of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan ChinaDepartment of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan ChinaDepartment of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan ChinaDepartment of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan ChinaDepartment of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan ChinaDepartment of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan ChinaJinan Key Lab of Respiratory Diseases for Children Jinan Children's Hospital Jinan ChinaAbstract Background The global spread of coronavirus disease 2019 (COVID‐19) has resulted in a significant disease burden, yet asthma patients do not have the expected high morbidity and mortality rates in the pandemics of COVID‐19. Objective To find the difference of angiotensin‐converting enzyme 2 (ACE2) in asthma and nonasthma children and evaluate the effect of inhaled corticosteroids (ICS) on its expression. Methods The ACE2, immunoglobulin E (IgE), and eosinophils were tested in different children. Results A total of 157 children aged 3–16 years were enrolled. The expression of ACE2 in asthma children were lower than nonasthma children (T = −2.512, p = .013). Allergic nonasthma children had a significant higher ACE2 expression than children with allergic asthma (p = .013) and nonallergic asthma (p = .029). The expression of ACE2 had no significant difference between first‐diagnosed asthma children and that had been treated with ICS for ≥6 months (F = 0.028, p = .598). The allergic asthma children showed a significantly higher eosinophils cells (EC) count than the allergic nonasthma (W = 200, p < .001) and nonallergic nonasthma children (W = 1089, p < .001). Nonallergic asthma children also had a significant higher EC count than the allergic non‐asthma (W = 182.5, p < .001) and nonallergic non‐asthma (W = 200.5, p < .001) children. There was no significant difference in IgE levels between asthmatic children and non‐asthmatic children (W = 2792.5, p = .18). Conclusion Circulating ACE2 levels in asthmatic children were lower than those in non‐asthmatic children and ICS treatment for ≥6 months did not affect the expression of ACE2 in peripheral blood in the asthma children.https://doi.org/10.1002/iid3.922angiotensin‐converting enzyme 2asthmachildrenCOVID‐19inhaled corticosteroids |
| spellingShingle | Xiang Ma Lesen Liu Jing Sun Yun Zhang Yanqin Liu Miao Liu Bing Wang Yuna Chang Yuling Han Zhongtao Gai Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids Immunity, Inflammation and Disease angiotensin‐converting enzyme 2 asthma children COVID‐19 inhaled corticosteroids |
| title | Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids |
| title_full | Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids |
| title_fullStr | Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids |
| title_full_unstemmed | Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids |
| title_short | Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids |
| title_sort | expression of circulating angiotensin converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids |
| topic | angiotensin‐converting enzyme 2 asthma children COVID‐19 inhaled corticosteroids |
| url | https://doi.org/10.1002/iid3.922 |
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