The Critical Impact of HIF-1a on Gastric Cancer Biology
Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in solid tumors. Under hypoxia conditions, HIF-1a protein is stabilized and forms a heterodimer with the HIF-1β subunit. The HIF-1 complex activates the transcription of numerous target genes in order...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-01-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/5/1/15 |
| _version_ | 1797700683835637760 |
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| author | Yoshihiko Kitajima Kohji Miyazaki |
| author_facet | Yoshihiko Kitajima Kohji Miyazaki |
| author_sort | Yoshihiko Kitajima |
| collection | DOAJ |
| description | Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in solid tumors. Under hypoxia conditions, HIF-1a protein is stabilized and forms a heterodimer with the HIF-1β subunit. The HIF-1 complex activates the transcription of numerous target genes in order to adapt the hypoxic environment in human cancer cells. In gastric cancer patients, HIF-1a activation following extended hypoxia strongly correlates with an aggressive tumor phenotype and a poor prognosis. HIF-1a activation has been also reported to occur via hypoxia-independent mechanisms such as PI3K/AKT/mTOR signaling and ROS production. This article argues for the critical roles of HIF-1a in glucose metabolism, carcinogenesis, angiogenesis, invasion, metastasis, cell survival and chemoresistance, focusing on gastric cancer. |
| first_indexed | 2024-03-12T04:25:09Z |
| format | Article |
| id | doaj.art-a846aab488984984b78df11e1b4db86b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T04:25:09Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a846aab488984984b78df11e1b4db86b2023-09-03T10:27:11ZengMDPI AGCancers2072-66942013-01-0151152610.3390/cancers5010015The Critical Impact of HIF-1a on Gastric Cancer BiologyYoshihiko KitajimaKohji MiyazakiHypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in solid tumors. Under hypoxia conditions, HIF-1a protein is stabilized and forms a heterodimer with the HIF-1β subunit. The HIF-1 complex activates the transcription of numerous target genes in order to adapt the hypoxic environment in human cancer cells. In gastric cancer patients, HIF-1a activation following extended hypoxia strongly correlates with an aggressive tumor phenotype and a poor prognosis. HIF-1a activation has been also reported to occur via hypoxia-independent mechanisms such as PI3K/AKT/mTOR signaling and ROS production. This article argues for the critical roles of HIF-1a in glucose metabolism, carcinogenesis, angiogenesis, invasion, metastasis, cell survival and chemoresistance, focusing on gastric cancer.http://www.mdpi.com/2072-6694/5/1/15HIF-1ahypoxiagastric cancer |
| spellingShingle | Yoshihiko Kitajima Kohji Miyazaki The Critical Impact of HIF-1a on Gastric Cancer Biology Cancers HIF-1a hypoxia gastric cancer |
| title | The Critical Impact of HIF-1a on Gastric Cancer Biology |
| title_full | The Critical Impact of HIF-1a on Gastric Cancer Biology |
| title_fullStr | The Critical Impact of HIF-1a on Gastric Cancer Biology |
| title_full_unstemmed | The Critical Impact of HIF-1a on Gastric Cancer Biology |
| title_short | The Critical Impact of HIF-1a on Gastric Cancer Biology |
| title_sort | critical impact of hif 1a on gastric cancer biology |
| topic | HIF-1a hypoxia gastric cancer |
| url | http://www.mdpi.com/2072-6694/5/1/15 |
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