BDNF Val66Met polymorphism and protein levels in Amniotic Fluid
<p>Abstract</p> <p>Background</p> <p>Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which plays survival- and growth-promoting activity in neuronal cells and it is involved in cellular plasticity mechanisms as it controls activity dependent synaptic transmis...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-02-01
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| Series: | BMC Neuroscience |
| Online Access: | http://www.biomedcentral.com/1471-2202/11/16 |
| _version_ | 1818766202184400896 |
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| author | Calabrese Francesca Moraschi Stefania Milanesi Elena Bellotti Daniela Marchina Eleonora Zanardini Roberta Bocchio-Chiavetto Luisella Cattaneo Annamaria Barlati Sergio Riva Marco Gennarelli Massimo |
| author_facet | Calabrese Francesca Moraschi Stefania Milanesi Elena Bellotti Daniela Marchina Eleonora Zanardini Roberta Bocchio-Chiavetto Luisella Cattaneo Annamaria Barlati Sergio Riva Marco Gennarelli Massimo |
| author_sort | Calabrese Francesca |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which plays survival- and growth-promoting activity in neuronal cells and it is involved in cellular plasticity mechanisms as it controls activity dependent synaptic transmission. A functional polymorphism (Val66Met) in the pro-region of BDNF, which affects the intracellular trafficking of proBDNF has been associated with memory and cognitive deficits as well as to an increased susceptibility for several psychiatric disorders especially those with a neurodevelopmental origin. To date, no study has evaluated the influence of the Val66Met polymorphism on BDNF levels in a peripheral system that may reflect fetal neurodevelopment. Therefore we investigated in amniotic fluids (AF) obtained from 139 healthy women during 15-17 week of pregnancy, BDNF protein levels in correlation with the Val66Met polymorphism.</p> <p>Results</p> <p>Interestingly we found a significant BDNF protein levels reduction in 55 Met carriers (Val/Met and Met/Met) (p = 0.002) as compared to 84 non carriers (Val/Val), and no effect of fetus gender, maternal age or gestation week on BDNF levels has been observed.</p> <p>Conclusion</p> <p>These results, although explorative, indicate that during fetal life the Val66Met genotype might influences BDNF protein levels in AF supporting the involvement of this polymorphism in behavioral and functional brain individual differences in the adulthood.</p> |
| first_indexed | 2024-12-18T08:30:14Z |
| format | Article |
| id | doaj.art-a8480f8cb8b8449cbbcd5840f036fa26 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-12-18T08:30:14Z |
| publishDate | 2010-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-a8480f8cb8b8449cbbcd5840f036fa262022-12-21T21:14:28ZengBMCBMC Neuroscience1471-22022010-02-011111610.1186/1471-2202-11-16BDNF Val66Met polymorphism and protein levels in Amniotic FluidCalabrese FrancescaMoraschi StefaniaMilanesi ElenaBellotti DanielaMarchina EleonoraZanardini RobertaBocchio-Chiavetto LuisellaCattaneo AnnamariaBarlati SergioRiva MarcoGennarelli Massimo<p>Abstract</p> <p>Background</p> <p>Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which plays survival- and growth-promoting activity in neuronal cells and it is involved in cellular plasticity mechanisms as it controls activity dependent synaptic transmission. A functional polymorphism (Val66Met) in the pro-region of BDNF, which affects the intracellular trafficking of proBDNF has been associated with memory and cognitive deficits as well as to an increased susceptibility for several psychiatric disorders especially those with a neurodevelopmental origin. To date, no study has evaluated the influence of the Val66Met polymorphism on BDNF levels in a peripheral system that may reflect fetal neurodevelopment. Therefore we investigated in amniotic fluids (AF) obtained from 139 healthy women during 15-17 week of pregnancy, BDNF protein levels in correlation with the Val66Met polymorphism.</p> <p>Results</p> <p>Interestingly we found a significant BDNF protein levels reduction in 55 Met carriers (Val/Met and Met/Met) (p = 0.002) as compared to 84 non carriers (Val/Val), and no effect of fetus gender, maternal age or gestation week on BDNF levels has been observed.</p> <p>Conclusion</p> <p>These results, although explorative, indicate that during fetal life the Val66Met genotype might influences BDNF protein levels in AF supporting the involvement of this polymorphism in behavioral and functional brain individual differences in the adulthood.</p>http://www.biomedcentral.com/1471-2202/11/16 |
| spellingShingle | Calabrese Francesca Moraschi Stefania Milanesi Elena Bellotti Daniela Marchina Eleonora Zanardini Roberta Bocchio-Chiavetto Luisella Cattaneo Annamaria Barlati Sergio Riva Marco Gennarelli Massimo BDNF Val66Met polymorphism and protein levels in Amniotic Fluid BMC Neuroscience |
| title | BDNF Val66Met polymorphism and protein levels in Amniotic Fluid |
| title_full | BDNF Val66Met polymorphism and protein levels in Amniotic Fluid |
| title_fullStr | BDNF Val66Met polymorphism and protein levels in Amniotic Fluid |
| title_full_unstemmed | BDNF Val66Met polymorphism and protein levels in Amniotic Fluid |
| title_short | BDNF Val66Met polymorphism and protein levels in Amniotic Fluid |
| title_sort | bdnf val66met polymorphism and protein levels in amniotic fluid |
| url | http://www.biomedcentral.com/1471-2202/11/16 |
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