Predicting β-lactam susceptibility from the genome of Streptococcus pneumoniae and other mitis group streptococci

Predicting β-lactam susceptibility from the genome of Streptococcus pneumoniae and other mitis group streptococci

IntroductionFor Streptococcus pneumoniae, β-lactam susceptibility can be predicted from the amino acid sequence of the penicillin-binding proteins PBP1a, PBP2b, and PBP2x. The combination of PBP-subtypes provides a PBP-profile, which correlates to a phenotypic minimal inhibitory concentration (MIC)....

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Bibliographic Details
Main Authors: Helle Brander Eriksen, Kurt Fuursted, Anders Jensen, Christian Salgård Jensen, Xiaohui Nielsen, Jens Jørgen Christensen, Patricia Shewmaker, Ana Rita Rebelo, Frank Møller Aarestrup, Kristian Schønning, Hans-Christian Slotved, the One Day in Denmark (ODiD) Consortium
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Microbiology
Subjects:
penicillin-binding proteins
penicillin
genotypic susceptibility
pneumococcus
Streptococcus
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1120023/full

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