Platelet Indices as Quility markers For Remission in patients with Leukemia
The purpose of this study was to investigate whether platelet indices [mean platelet volume (MPV) and platelet distribution width (PDW)] could serve as surrogate marker for follow-up in patients with leukemia. Blood samples were obtained from 48 patients with leukemia at diagnosis before chemotherap...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1707 |
| _version_ | 1818906440313602048 |
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| author | Suleimman Al-Sweedan Ismail Matalka |
| author_facet | Suleimman Al-Sweedan Ismail Matalka |
| author_sort | Suleimman Al-Sweedan |
| collection | DOAJ |
| description | The purpose of this study was to investigate whether platelet indices [mean platelet volume (MPV) and platelet distribution width (PDW)] could serve as surrogate marker for follow-up in patients with leukemia. Blood samples were obtained from 48 patients with leukemia at diagnosis before chemotherapy and at the time of remission (mean age: 17.92 years;
24 males and 24 females). We measured the blood platelet indices using an automated counter. MPV was higher at the time of remission, but it was not statistically significant. However, PDW was significantly lower (P<0.001) at the time of remission. There was no significant difference in the MPV or PDW in patients with acute lymphoblastic leukemia versus acute myeloblastic, males versus females, in patients on chemotherapy versus no chemotherapy at the time of remission, or patient at remission versus healthy control. In conclusion, we found no significant difference in the MPV between the two groups. PDW proposed as indicators of certain pathologic conditions and it seems possible to use PDW as surrogate markers foe follow up in patients with leukemia. However, platelet indices (MPV and PDW) cannot be used as indicator to discriminate between the subtypes of leukemia. The potential role of platelet indices in leukemia remains to be investigated by a multi institutional level to verify the possible clinical significance of this finding. |
| first_indexed | 2024-12-19T21:39:16Z |
| format | Article |
| id | doaj.art-a849286f300f4d548afbb9e0a492c9e7 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-19T21:39:16Z |
| publishDate | 2014-08-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-a849286f300f4d548afbb9e0a492c9e72022-12-21T20:04:42ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011Platelet Indices as Quility markers For Remission in patients with LeukemiaSuleimman Al-Sweedan0Ismail Matalka1Department of Pediatrics, Jordan University of Science and Technology, Irbid, JordanJordan University of science and TechnologyThe purpose of this study was to investigate whether platelet indices [mean platelet volume (MPV) and platelet distribution width (PDW)] could serve as surrogate marker for follow-up in patients with leukemia. Blood samples were obtained from 48 patients with leukemia at diagnosis before chemotherapy and at the time of remission (mean age: 17.92 years; 24 males and 24 females). We measured the blood platelet indices using an automated counter. MPV was higher at the time of remission, but it was not statistically significant. However, PDW was significantly lower (P<0.001) at the time of remission. There was no significant difference in the MPV or PDW in patients with acute lymphoblastic leukemia versus acute myeloblastic, males versus females, in patients on chemotherapy versus no chemotherapy at the time of remission, or patient at remission versus healthy control. In conclusion, we found no significant difference in the MPV between the two groups. PDW proposed as indicators of certain pathologic conditions and it seems possible to use PDW as surrogate markers foe follow up in patients with leukemia. However, platelet indices (MPV and PDW) cannot be used as indicator to discriminate between the subtypes of leukemia. The potential role of platelet indices in leukemia remains to be investigated by a multi institutional level to verify the possible clinical significance of this finding.https://mjhid.org/index.php/mjhid/article/view/1707PlateletsIndicesLeukemia |
| spellingShingle | Suleimman Al-Sweedan Ismail Matalka Platelet Indices as Quility markers For Remission in patients with Leukemia Mediterranean Journal of Hematology and Infectious Diseases Platelets Indices Leukemia |
| title | Platelet Indices as Quility markers For Remission in patients with Leukemia |
| title_full | Platelet Indices as Quility markers For Remission in patients with Leukemia |
| title_fullStr | Platelet Indices as Quility markers For Remission in patients with Leukemia |
| title_full_unstemmed | Platelet Indices as Quility markers For Remission in patients with Leukemia |
| title_short | Platelet Indices as Quility markers For Remission in patients with Leukemia |
| title_sort | platelet indices as quility markers for remission in patients with leukemia |
| topic | Platelets Indices Leukemia |
| url | https://mjhid.org/index.php/mjhid/article/view/1707 |
| work_keys_str_mv | AT suleimmanalsweedan plateletindicesasquilitymarkersforremissioninpatientswithleukemia AT ismailmatalka plateletindicesasquilitymarkersforremissioninpatientswithleukemia |